Radiation protection: desensitization to radiation.

1. RADIATION PROTECTION:
DESENSITIZATION TO
RADIATION.
DMITRI POPOV, PHD RADIOBIOLOGY, MD (RUSSIA),
ADVANCED MEDICAL TECHNOLOGY AND SYSTEMS INC.
INTERVACCINE@GMAIL.COM

2. • METHOD: RADIATION PROTECTION: DESENSITIZATION TO RADIATION.
• DMITRI POPOV
• FULL-TEXT METHOD · MAY 2015
• ADD RESOURCES
• FILE NAME: RADIATION PROTECTION DESENSITIZATION TO RADIATION..PPTX
DOI: 10.13140/RG.2.1.3464.9849

3. RADIATION PROTECTION
• RADIATION ALLERGEN IMMUNOTHERAPY, ALSO KNOWN
AS DESENSITIZATION OR HYPO-SENSITIZATION, IS A MEDICAL TREATMENT FOR
ACUTE TYPES OF RADIATION ALLERGIES – ACUTE RADIATION SYNDROMES.
• IT IS USEFUL FOR GENERALLY FOR RADIATION ALLERGIES, ALLERGIES TO INSECT
BITES.

4. RADIATION PROTECTION.
• ANTI-RADIATION IMMUNOTHERAPY INVOLVES EXPOSING PEOPLE TO LARGER
AND LARGER AMOUNTS OF RADIATION ALLERGEN IN AN ATTEMPT TO CHANGE
THE IMMUNE SYSTEM'S RESPONSE TO HIGH DOSES OF RADIATION.

5. RADIATION PROTECTION
• SUBCUTANEOUS ANTI-RADIATION IMMUNOTHERAPY, ALSO KNOWN AS ANTI
RADIATION ALLERGY SHOTS, IS THE EFFECTIVE ROUTE OF ADMINISTRATION AND
CONSISTS OF INJECTIONS OF IRRADIATED PLANT ALLERGEN EXTRACT
(ISOLATED FROM IRRADIATED PLANTS).
• SUBCUTANEOUS ANTI-RADIATION IMMUNOTHERAPY PROTOCOLS GENERALLY
INVOLVE WEEKLY INJECTIONS DURING A BUILD-UP PHASE, FOLLOWED BY
MONTHLY MAINTENANCE INJECTIONS FOR A PERIOD OF 3–5 YEARS.

6. RADIATION PROTECTION
• IN DESENSITIZATION ANTI RADIATION IMMUNOTHERAPY THE AIM IS TO INDUCE OR RESTORE TOLERANCE TO THE
RADIATION ACTIVATED ALLERGEN BY REDUCING ITS TENDENCY TO INDUCE IGE PRODUCTION.
• MAMMALS ARE DESENSITIZED THROUGH THE ADMINISTRATION OF ESCALATING DOSES OF RADIATION ALLERGEN
THAT GRADUALLY DECREASES THE IGE-DOMINATED RESPONSE.
• THE OBJECTIVE OF RADIATION IMMUNOTHERAPY IS TO DIRECT THE IMMUNE RESPONSE AWAY FROM HUMORAL
IMMUNITY AND TOWARD CELLULAR IMMUNITY, THEREBY ENCOURAGING THE BODY TO PRODUCE LESS IGE
ANTIBODIES AND MORE TH1 REGULATORY T CELLS, WHICH SECRETE IL-10 AND/OR TGF-BETA, WHICH SKEW THE
RESPONSE AWAY FROM IGE PRODUCTION.
• GENERAL PRINCIPALS CONSIST IN CREATION AN INCREASE IN ALLERGEN-SPECIFIC IGG4 ANTIBODIES AND A
DECREASE IN ALLERGEN-SPECIFIC IGE ANTIBODIES, AS WELL AS DIMINISHED REACTIONS OF MAST
CELLS AND BASOPHILS, IMPORTANT CELL TYPES THAT ARE LARGE CONTRIBUTORS TO ALLERGIC REACTION.

7. RADIATION PROTECTION.
• A VARIETY OF RADIATION ALLERGEN (TOXIN) CURRENTLY BEING TESTED TO IMPROVE EFFICACY OF ANTI-
RADIATION IMMUNOTHERAPY.
• IMPORTANT VARIANT OF IMMUNOTHERAPY BEING STUDIED IS IN IRRADIATED PLANT ALTERING THE PROTEIN
STRUCTURE OF THE ALLERGEN TO DECREASE IMMUNE RESPONSE. DEVELOPING TOLERANCE TO RADIATION FOR
THE PATIENT AIM OF SCIENTIFIC INVESTIGATION .
• EXTENSIVE IRRADIATION OF SOME PLANTS CAN CHANGE THE CONFORMATION OF EPITOPES RECOGNIZED BY IGE
ANTIBODIES AND MAKE RADIATION NAÏVE MAMMAL TOLERANT TO HIGH DOSES OF RADIATION.
• IN FACT, STUDIES SHOW THAT REGULAR ADMINISTRATION OF RADIATION ALLERGENS CAN DECREASE RADIATION
REACTIONS RESOLUTION.
• ANOTHER APPROACH REGARDING CHANGES IN PROTEIN IS TO CHANGE SPECIFIC AMINO ACIDS IN THE PROTEIN TO
DECREASE RECOGNITION OF THE RADIATION ALLERGEN BY RADIATION ALLERGEN-SPECIFIC ANTIBODIES.

8. RADIATION PROTECTION

9. RADIATION PROTECTION

10. RADIATION PROTECTION.
• REVIEW ARTICLE KOREAN J PEDIATR 2013;56(12):505-513
HTTP://DX.DOI.ORG/10.3345/KJP.2013.56.12.505 PISSN 1738-1061•EISSN 2092-7258
• MECHANISMS OF IMMUNE TOLERANCE TO ALLERGENS IN CHILDREN UMUT C. KUCUKSEZER,
PHD1 , CEVDET OZDEMIR, MD2 , MÜBECCEL AKDIS, MD, PHD3 , CEZMI A. AKDIS, MD3,4 1
DEPARTMENT OF IMMUNOLOGY, INSTITUTE OF EXPERIMENTAL MEDICINE (DETAE), ISTANBUL
UNIVERSITY, ISTANBUL, TURKEY, 2 DEPARTMENT OF PEDIATRIC ALLERGY, ATASEHIR HOSPITAL,
MEMORIAL HEALTH GROUP, ISTANBUL, TURKEY, 3 SWISS INSTITUTE OF ALLERGY AND ASTHMA
RESEARCH (SIAF), UNIVERSITY OF ZÜRICH, DAVOS, SWITZERLAND, 4 CHRISTINE KÜHNE –
CENTER FOR ALLERGY RESEARCH AND EDUCATION, DAVOS, SWITZERLAND
• IMAGES FROM SLIDES 7 AND 8 COMES FROM ARTICLE MENTIONED ABOVE.

11. RADIATION PROTECTION.
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