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Dic
- 1. Disseminated Intravascular Coagulation Prepared by; Matutina, Kristine Ann Paala, mary Roselyn Palu-ay, MaeTherese Poblacion, Sharmaine Puro, Shane Iris Sobreguil, Laarni
- 2. Disseminated Intravascular Coagulation A hemorrhagic disorder, in which there is an uncontrolled inappropriate formation and lysis of fibrin within the blood vessels. As fibrin is formed, several clotting proteins as well as naturally occurring inhibitors and platelets are consumed faster than they are synthesized. A secondary group of symptoms that is always triggered by a primary condition that does not necessarily involve coagulation.
- 3. Types of dic Disseminated Intravascular Coagulation Acute DIC severe and often life- threatening Rapid, and both fibrinogen and platelets may be depleted ChronicDIC may have mild manifestations of the disorder or be recognizable only by laboratory data
- 4. Causes Disseminated Intravascular Coagulation Release or entry of tissue factors that act as coagulants into the bloodstream Extensive endothelial damage Septicemia Complications of pregnancy
- 5. Pathophysiology Disseminated Intravascular Coagulation Inflammation Clotting Factor Activated Uncontrolled thrombin formation Depletion of clotting factor Massive Hemorrhage
- 6. Disseminated Intravascular Coagulation Bleeding signs and symptoms Petechiae Purpura Arterial line oozing Venipuncture site bleeding Clinical manifestation
- 7. Clinical manifestation Disseminated Intravascular Coagulation Organ damage Skin, bone and bone marrow necrosis may be seen
- 8. Significant LaboratoryFindingsin DIC Disseminated Intravascular Coagulation Test Normal Range DIC D- dimer 0- 100 ng/ mL > 500 ng/ mL Fibrinogen 200- 400 mg/ dL < 200 mgl dL Platelet count 200- 400 ร 109/ L <200- 400 ร 109/ L Peripheral blood smear------ Fragmented RBC Platelet Count--------------------------- Decreased Fibrinogen ------------------------------- Decreased Thrombin time ------------------------- Prolonged Reptilase time---------------------------Prolonged
- 9. treatment Disseminated Intravascular Coagulation Elimination of the precipitating factor if possible Replacement of coagulation factors and platelets Inhibition of the clotting process with heparin or other agents.