2. biotransformation
• Biotransformation is biological process
whereby an organic compound is modified
into reversible product.
• These involve simple, chemically defined
reaction catalysed by enzyme present in the
cell.
• ( eg, microbial, plant and animal)
3. • Microbial cell have advantage over plant and
animal cell due to their high surface volume ratio,
rapid growth high rates of metabolism for the
efficient transformation of the substetem added.
• The substrate to be transfarmed can be growing
cell, resting cell, dried cell, or to ezyme isolate
from these cell.
• Forming meadium shoud be agitated.
• Aerated fermentir or packed in column for
continous opration.
4. • The can be immoblisedon solid support increase
there stability and prolonger operation.
• Biotransformation were carried with plant cell
successfully for a varieties of novel compounds,
eg cardiac glycoside, digoxin, benzyl isoquinoline
etc.
• Biotransformatn in plant cell congugated
reaction, these cellore superior to microoranism
