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Website:
https://insilicodb.com
Facebook:
https://www.facebook.com/Insilicodb
Twitter:
@InSilicoDB
InSilicoDB
the collaborative genomics hub
Makers of
InSilico
Genomics S.A.
InSilicoDB
Genome data: our very own
“Google” medical map
2
The genome data represents a first step toward a high-definition medical map of every individual — a digitized human being. We are moving into the big data-per-
individual era (with your very own “Google” medical map)
InSilicoDB
Navigating it could save your life
Should I have a regular melanoma screening?
3
Navigating your medical digital map it could save your life

How would that work?

	 1.	 you sequence your genome

	 2.	 a team of biologists analyses it

	 3.	 they discover you are at-risk for developing skin cancer

	 4.	 you start regularly visiting your dermatologist 

	 5.	 she discovers a small tumor, and removes it before it kills you

Currently, for you and I, even if we sequenced our genomes, we don’t have access to our own private team of biologists. And since it's not affordable, or even possible,
that we all go to visit every kind of doctor every month, we do nothing. And the unlucky among us that should get their skin checked… die
InSilicoDB
4
We need biologists to
navigate our genomes
Biologists need to
interact with data in
collaboration with
their colleagues,
analysing them in
multiple analysis tools
using different formats
We really need to make it easy for biologists to help us navigate our medical map.

In order to analyse our genomes biologists need to interact with data in collaboration with their colleagues, analysing them in multiple analysis tools using different
formats
InSilicoDB
but it’s impossible for
them without programming skills
• Data is huge
• Data are scattered, not
standardised
• The lack of organisation is
a barrier to collaboration
5
But:

	 •	 A genome is so massive that it could fill up an entire hard drive

	 •	 The data has to be moved around but it's scattered, and

	 •	 There are no standards

And biologists are not able to handle these data, basically because they don’t know how to program.
InSilicoDB
InSilicoDB
the collaborative genomics hub
6
7,452
8,000
60
We built InSilico DB, a collaborative genomics hub that makes it possible for biologists to analyse genomics data without any programming skills. We created a hub
where data is centralised, it flows in, is standardised, curated and then flows out to various analysis tools scientists use to interrogate and interpret the data.
InSilicoDB
7
All genome data is centralised on a
secure cloud allowing easy collaboration
And interactive collaborative analysis of the data becomes possible, and fun!
InSilicoDB
8
And interactive analysis
of the data becomes easy
And interactive collaborative analysis of the data becomes possible, and fun!
InSilicoDB
Biologists are now moving their research
online, studying “digitized” humans
9
Our customers are now able to analyse genome data and are moving their work from the bench to the computer. It’s amazing how our product is actually transforming
the way our customers work!
InSilicoDB
•
More than 15% monthly growth rate
User acquisition
0
2000
4000
6000
8000
3000 registered users
3 years - 3,000 users
no marketing efforts - word of mouth following
presentations and scientific publication
7,456 registered users
4 months - 4,400 users
marketing efforts in social networks
targeting biologists
INSILICO DB TRACTION
Original expectation: 1,000 new users/month at €5/user
June
€15/new user
July
€10/new user
August
€6/new user
September
€3/new user
2012 2013 May 2015 Oct 2015
e-marketing campaign results
Last 30 days results: 1,190 new users at €2.3 / per user
INSILICO DB ACTIVITY
6 month period Number of Active Users*
Number of Users uploading
personal data
Number of Users that did
an analysis
Jan-Jun 1,232 127 623
Feb-Jul 2,156 187 904
page likes today15,188
Cost per User
2014
10
We are getting significant traction, growing at 15% month/month to over 8,000 scientists , 400,000 genomes, 50 new discoveries in scientific publications
InSilicoDB
Billions of people to get sequenced,
InSilico will put those genomes into the
hands of those that can interpret them
11
InSilicoDB
In the next decade, as billions of us get sequenced, InSilico will put our genomes directly into the hands of these biologists who can use them to improve our health and
lifestyle, for our own benefit, and under our own terms.
InSilicoDB
Currently raising a round to empower
an agile and experienced team supported
by product, market and business mentors
David Weiss, Founder & CEO
Bioengineer, PhD in bioinformatics
ULB, did genomics research at
Broad Institute and MIT.
Molecular Biologist, PhD in
Bioinformatics from University of
Manchester
Robin Duqué, Full Stack Dev.
Master in Biotechnology
Previously VP of engineering @
Sparkcentral, an SV startup that raised
$18M
Main front-end developper
2 years experience on InSilico DB
MD, dermatologist
5 year experience in InSilico DB
James Cauwelier, Systems Architect
Jaro Vanderheijden, Web Developper
Industrial Engineer, founding team
member with 5 year experience building
InSilico DB. Previously, software
engineer @ ING (banking)
Virginie de Schaetzen, Biocurator
Investment banker and Private Equity
investor, Member of the Board of
Ageas insurance group
PhD in Molecular Biology
Experience in R&D subsidy
management
Lionel Perl, Chairman of the Board Andréa Goldsztein, Adm. Assistant
12
Alain Coletta, Founder & Exec. director
Our team:

Alain and I were working for years as data scientists helping biologists use genome data.

James fresh from building the infrastructure from SparkCentral jumped in to build the platform

Founders of largest Belgian internet exit Ogone are full in

We are currently raising a round to:

	 •	 Further Increase platform ease-of-use and reliability

	 •	 grow the community of biologists

	 •	 add more analysis tools and data

	 •	 invite individuals to participate through their genomes

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InSilico DB the collaborative genomics hib

  • 2. InSilicoDB Genome data: our very own “Google” medical map 2 The genome data represents a first step toward a high-definition medical map of every individual — a digitized human being. We are moving into the big data-per- individual era (with your very own “Google” medical map)
  • 3. InSilicoDB Navigating it could save your life Should I have a regular melanoma screening? 3 Navigating your medical digital map it could save your life How would that work? 1. you sequence your genome 2. a team of biologists analyses it 3. they discover you are at-risk for developing skin cancer 4. you start regularly visiting your dermatologist 5. she discovers a small tumor, and removes it before it kills you Currently, for you and I, even if we sequenced our genomes, we don’t have access to our own private team of biologists. And since it's not affordable, or even possible, that we all go to visit every kind of doctor every month, we do nothing. And the unlucky among us that should get their skin checked… die
  • 4. InSilicoDB 4 We need biologists to navigate our genomes Biologists need to interact with data in collaboration with their colleagues, analysing them in multiple analysis tools using different formats We really need to make it easy for biologists to help us navigate our medical map. In order to analyse our genomes biologists need to interact with data in collaboration with their colleagues, analysing them in multiple analysis tools using different formats
  • 5. InSilicoDB but it’s impossible for them without programming skills • Data is huge • Data are scattered, not standardised • The lack of organisation is a barrier to collaboration 5 But: • A genome is so massive that it could fill up an entire hard drive
 • The data has to be moved around but it's scattered, and
 • There are no standards
 And biologists are not able to handle these data, basically because they don’t know how to program.
  • 6. InSilicoDB InSilicoDB the collaborative genomics hub 6 7,452 8,000 60 We built InSilico DB, a collaborative genomics hub that makes it possible for biologists to analyse genomics data without any programming skills. We created a hub where data is centralised, it flows in, is standardised, curated and then flows out to various analysis tools scientists use to interrogate and interpret the data.
  • 7. InSilicoDB 7 All genome data is centralised on a secure cloud allowing easy collaboration And interactive collaborative analysis of the data becomes possible, and fun!
  • 8. InSilicoDB 8 And interactive analysis of the data becomes easy And interactive collaborative analysis of the data becomes possible, and fun!
  • 9. InSilicoDB Biologists are now moving their research online, studying “digitized” humans 9 Our customers are now able to analyse genome data and are moving their work from the bench to the computer. It’s amazing how our product is actually transforming the way our customers work!
  • 10. InSilicoDB • More than 15% monthly growth rate User acquisition 0 2000 4000 6000 8000 3000 registered users 3 years - 3,000 users no marketing efforts - word of mouth following presentations and scientific publication 7,456 registered users 4 months - 4,400 users marketing efforts in social networks targeting biologists INSILICO DB TRACTION Original expectation: 1,000 new users/month at €5/user June €15/new user July €10/new user August €6/new user September €3/new user 2012 2013 May 2015 Oct 2015 e-marketing campaign results Last 30 days results: 1,190 new users at €2.3 / per user INSILICO DB ACTIVITY 6 month period Number of Active Users* Number of Users uploading personal data Number of Users that did an analysis Jan-Jun 1,232 127 623 Feb-Jul 2,156 187 904 page likes today15,188 Cost per User 2014 10 We are getting significant traction, growing at 15% month/month to over 8,000 scientists , 400,000 genomes, 50 new discoveries in scientific publications
  • 11. InSilicoDB Billions of people to get sequenced, InSilico will put those genomes into the hands of those that can interpret them 11 InSilicoDB In the next decade, as billions of us get sequenced, InSilico will put our genomes directly into the hands of these biologists who can use them to improve our health and lifestyle, for our own benefit, and under our own terms.
  • 12. InSilicoDB Currently raising a round to empower an agile and experienced team supported by product, market and business mentors David Weiss, Founder & CEO Bioengineer, PhD in bioinformatics ULB, did genomics research at Broad Institute and MIT. Molecular Biologist, PhD in Bioinformatics from University of Manchester Robin Duqué, Full Stack Dev. Master in Biotechnology Previously VP of engineering @ Sparkcentral, an SV startup that raised $18M Main front-end developper 2 years experience on InSilico DB MD, dermatologist 5 year experience in InSilico DB James Cauwelier, Systems Architect Jaro Vanderheijden, Web Developper Industrial Engineer, founding team member with 5 year experience building InSilico DB. Previously, software engineer @ ING (banking) Virginie de Schaetzen, Biocurator Investment banker and Private Equity investor, Member of the Board of Ageas insurance group PhD in Molecular Biology Experience in R&D subsidy management Lionel Perl, Chairman of the Board Andréa Goldsztein, Adm. Assistant 12 Alain Coletta, Founder & Exec. director Our team: Alain and I were working for years as data scientists helping biologists use genome data. James fresh from building the infrastructure from SparkCentral jumped in to build the platform Founders of largest Belgian internet exit Ogone are full in We are currently raising a round to: • Further Increase platform ease-of-use and reliability • grow the community of biologists • add more analysis tools and data • invite individuals to participate through their genomes