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New ALS Gene Discovery
Made Possible Through Ice
Bucket Funding
David Bohn
Introduction
 The recipient of a bachelor's degree in
English from Hamilton College, David
Bohn is a native of Redding, CT, who has
served as president of Preferred Utilities
Manufacturing Corporation since 1995. In
addition to his professional pursuits,
Redding, CT-based David Bohn supports
numerous nonprofit organizations,
including the ALS Association.
The ALS Ice Bucket Challenge became a
viral sensation in 2014 and prompted
millions of people worldwide to dump a
bucket of ice over their heads to help raise
awareness for the degenerative disorder
ALS. According to the ALS Association,
the campaign helped generate more than
$115 million, funds which it has put
toward patient and community services as
well as research in areas such as gene
discovery and drug development.
ALS
 More than 25 ALS genes have been
discovered throughout history, and five
of those have been discovered since the
first Ice Bucket Challenge.
The most recent breakthrough is the
discovery of the KIF5A gene, which
was made possible through a
collaborative effort between more than
250 researchers analyzing genetic data
from more than 101,000 samples.
KIF5A is a microtubule-based motor
protein that plays a crucial role in
motor neuron health. By discovering
the gene, researchers now have
another target for therapeutic drug
development. Other genes discovered
since the Ice Bucket Challenge began
include C21orf2, TBK1, NEK1, and
TUBA4A.

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New ALS Gene Discovery Made Possible Through Ice Bucket Funding

  • 1. New ALS Gene Discovery Made Possible Through Ice Bucket Funding David Bohn
  • 2. Introduction  The recipient of a bachelor's degree in English from Hamilton College, David Bohn is a native of Redding, CT, who has served as president of Preferred Utilities Manufacturing Corporation since 1995. In addition to his professional pursuits, Redding, CT-based David Bohn supports numerous nonprofit organizations, including the ALS Association. The ALS Ice Bucket Challenge became a viral sensation in 2014 and prompted millions of people worldwide to dump a bucket of ice over their heads to help raise awareness for the degenerative disorder ALS. According to the ALS Association, the campaign helped generate more than $115 million, funds which it has put toward patient and community services as well as research in areas such as gene discovery and drug development.
  • 3. ALS  More than 25 ALS genes have been discovered throughout history, and five of those have been discovered since the first Ice Bucket Challenge. The most recent breakthrough is the discovery of the KIF5A gene, which was made possible through a collaborative effort between more than 250 researchers analyzing genetic data from more than 101,000 samples. KIF5A is a microtubule-based motor protein that plays a crucial role in motor neuron health. By discovering the gene, researchers now have another target for therapeutic drug development. Other genes discovered since the Ice Bucket Challenge began include C21orf2, TBK1, NEK1, and TUBA4A.