Week 7: Hematological System Often in the medical field, an emphasis is placed on the importance of the heart and the lungs. While these two organs are vital to the sustainability of life, the blood is what makes the cardiovascular and respiratory systems function—it’s the connection for the heart and lungs. For this reason, disorders of the hematological system can be potentially devastating for patients. Consider the case of Connie Prochnow. Connie was diagnosed with leukemia after seeking medical care for bruising, shortness of breath, and exhaustion. Her blood disorder resulted in alterations that impacted other body systems, including her respiratory system (UW Health, 2012). Since the heart and the lungs rely so heavily on the blood, it is important that hematological disorders are quickly identified and managed. This week, as you focus on hematological disorders commonly presented to advanced practice nurses, you examine the pathophysiology of anemia. You also explore the impact of patient factors on anemic disorders. Reference Prochnow, C. (n.d.). Restoring hope: A cancer patient shares her story. Retrieved September 11, 2012, from http://www.uwhealth.org/uw-carbone-cancer-center/restoring-hope-a-cancer-patient-shares-her-story/20371 Learning Objectives Students will: · Analyze the pathophysiology of anemia · Compare the pathophysiology of iron deficiency anemia to the pathophysiology of other types of anemia · Evaluate the impact of patient factors on anemic disorders · Understand and apply key terms, concepts, and principles related to alterations of the hematological system Photo Credit: JPC-PROD/iStock/Getty Images Plus/Getty images Learning Resources Required Readings Huether, S. E., & McCance, K. L. (2012). Understanding pathophysiology (Laureate custom ed.). St. Louis, MO: Mosby. · Chapter 19, “Structure and Function of the Hematologic System” This chapter examines components of the hematologic system, development of blood cells, mechanisms of hemostasis, and hematologic value changes in pediatrics and geriatrics. It also focuses on common blood tests for hematologic disorders. · Chapter 20, “Alterations of Hematologic Function” This chapter focuses on common alterations of hematologic function, including alterations of erythrocyte function, leukocyte function, lymphoid function, splenic function, platelets, and coagulation. · Chapter 21, “Alterations of Hematologic Function in Children” This chapter expands on alterations of hematologic function by presenting disorders that affect children, such as disorders of erythrocytes, coagulation, and platelets. McPhee, S. J., & Hammer, G. D. (2010). Pathophysiology of disease: An introduction to clinical medicine (Laureate Education, Inc., custom ed.). New York, NY: McGraw-Hill Medical. · Chapter 6, “Blood Disorders” This chapter begins by exploring the anatomy and physiology of blood and the coagulation system. It then examines two types of anemia caused by red cell disorders.

1. Week 7: Hematological System
Often in the medical field, an emphasis is placed on the
importance of the heart and the lungs. While these two organs
are vital to the sustainability of life, the blood is what makes
the cardiovascular and respiratory systems function—it’s the
connection for the heart and lungs. For this reason, disorders of
the hematological system can be potentially devastating for
patients. Consider the case of Connie Prochnow. Connie was
diagnosed with leukemia after seeking medical care for
bruising, shortness of breath, and exhaustion. Her blood
disorder resulted in alterations that impacted other body
systems, including her respiratory system (UW Health, 2012).
Since the heart and the lungs rely so heavily on the blood, it is
important that hematological disorders are quickly identified
and managed.
This week, as you focus on hematological disorders commonly
presented to advanced practice nurses, you examine the
pathophysiology of anemia. You also explore the impact of
patient factors on anemic disorders.
Reference
Prochnow, C. (n.d.). Restoring hope: A cancer patient shares
her story. Retrieved September 11, 2012,
from http://www.uwhealth.org/uw-carbone-cancer-
center/restoring-hope-a-cancer-patient-shares-her-story/20371
Learning Objectives
Students will:
· Analyze the pathophysiology of anemia
· Compare the pathophysiology of iron deficiency anemia to the
pathophysiology of other types of anemia
· Evaluate the impact of patient factors on anemic disorders
· Understand and apply key terms, concepts, and principles
related to alterations of the hematological system
Photo Credit: JPC-PROD/iStock/Getty Images Plus/Getty
images

2. Learning Resources
Required Readings
Huether, S. E., & McCance, K. L. (2012). Understanding
pathophysiology (Laureate custom ed.). St. Louis, MO: Mosby.
· Chapter 19, “Structure and Function of the Hematologic
System”
This chapter examines components of the hematologic system,
development of blood cells, mechanisms of hemostasis, and
hematologic value changes in pediatrics and geriatrics. It also
focuses on common blood tests for hematologic disorders.
· Chapter 20, “Alterations of Hematologic Function”
This chapter focuses on common alterations of hematologic
function, including alterations of erythrocyte function,
leukocyte function, lymphoid function, splenic function,
platelets, and coagulation.
· Chapter 21, “Alterations of Hematologic Function in
Children”
This chapter expands on alterations of hematologic function by
presenting disorders that affect children, such as disorders of
erythrocytes, coagulation, and platelets.
McPhee, S. J., & Hammer, G. D. (2010). Pathophysiology of
disease: An introduction to clinical medicine (Laureate
Education, Inc., custom ed.). New York, NY: McGraw-Hill
Medical.
· Chapter 6, “Blood Disorders”
This chapter begins by exploring the anatomy and physiology of
blood and the coagulation system. It then examines two types of

3. anemia caused by red cell disorders. White blood cell disorders
and platelet disorders are also examined.
Optional Resources
American Sickle Cell Anemia Association. (2010). Retrieved
from http://www.ascaa.org/
Discussion: Anemia
In clinical settings, advanced practice nurses often encounter
patients with blood disorders such as anemia. Consider the case
of a 17-year-old girl who is rushed to the emergency room after
suddenly fainting. The girl’s mother reports that her daughter
has had difficulty concentrating for the past week, frequently
becomes dizzy, and has not been eating normally due to
digestion problems. The mother also informs the nurse that their
family has a history of anemia. With the family history of
anemia, it appears that this is the likely diagnosis. However, in
order to properly diagnose and treat the patient, not only must
her symptoms and family history be considered, but also factors
such as gender, ethnicity, age, and behavior. This poses the
question: How do patient factors impact the incidence and
prevalence of different types of anemia?
To Prepare
· Review Chapter 20 in the Huether and McCance text. Reflect
on the pathophysiological mechanisms of iron deficiency
anemia.
· Select one of the following types of anemia: pernicious
anemia, folate deficiency anemia, sideroblastic anemia, chronic
inflammation anemia, or post-hemorrhagic anemia. Identify the
pathophysiological mechanisms of the anemia you selected.
· Consider the similarities and differences between iron
deficiency anemia and the type of anemia you selected.
· Reflect on how patient factors such as genetics, gender,
ethnicity, age, and behavior might impact these anemic
disorders.

4. By Day 3
Post an explanation of the pathophysiological mechanisms of
iron deficiency anemia and the anemia you selected. Compare
these two types of anemia, as well as their potential causes.
Finally, explain how genetics, gender, ethnicity, age, and
behavior might impact the anemic disorders you selected.
Read a selection of your colleagues’ responses.
By Day 6
Week 7: Hematological System
Often in the medical field, an emphasis is placed on the
importance of the heart and the lungs.
While these two organs are vital to the sustainability of life, the
blood is what makes the
cardiovascular and respiratory systems function
—
it’s the connection
for the heart and lungs. For
this reason, disorders of the hematological system can be
potentially devastating for patients.
Consider the case of Connie Prochnow. Connie was diagnosed
with leukemia after seeking
medical care for bruising, shortness of brea
th, and exhaustion. Her blood disorder resulted in
alterations that impacted other body systems, including her
respiratory system (UW Health,
2012). Since the heart and the lungs rely so heavily on the
blood, it is important that
hematological disorders ar
e quickly identified and managed.
This week, as you focus on hematological disorders commonly
presented to advanced
practice nurses, you examine the pathophysiology of anemia.

5. You also explore the
impact of patient factors on anemic disorders.
Reference
Pr
ochnow, C. (n.d.). Restoring hope: A cancer patient shares her
story. Retrieved September 11, 2012, from
http://www.uwhealth
.org/uw
-
carbone
-
cancer
-
center/restoring
-
hope
-
a
-
cancer
-
patient
-
shares
-
her
-
story/20371
Learning Objectives
Students will:

6. ·
Analyze the pathophysiology of anemia
·
Compare the pathophysiology of iron deficiency anemia to the
pathophysiology of other
types of ane
mia
·
Evaluate the impact of patient factors on anemic disorders
·
Understand and apply key terms, concepts, and principles
related to alterations of the
hematological system
Photo Credit: JPC
-
PROD/iStock/Getty Images Plus/Getty images
Lear
ning Resources
Required Readings
Huether, S. E., & McCance, K. L. (2012).
Understanding pathophysiology
(Laureate custom

7. ed.). St. Louis, MO: Mosby.
·
Chapter 19, “Structure and Function of the Hematologic
System”
This chapter examines components of the hematologic system,
development of blood cells,
mechanisms of hemostasis, and hematologic value changes in
pediatrics and geriatrics. It also
focuses on common blood tests for hematologic disorders.
·
Chapter 20, “Al
terations of Hematologic Function”
This chapter focuses on common alterations of hematologic
function, including alterations of
erythrocyte function, leukocyte function, lymphoid function,
splenic function, platelets, and
coagulation.
·

8. Chapter 21, “Alte
rations of Hematologic Function in Children”
Week 7: Hematological System
Often in the medical field, an emphasis is placed on the
importance of the heart and the lungs.
While these two organs are vital to the sustainability of life, the
blood is what makes the
cardiovascular and respiratory systems function—it’s the
connection for the heart and lungs. For
this reason, disorders of the hematological system can be
potentially devastating for patients.
Consider the case of Connie Prochnow. Connie was diagnosed
with leukemia after seeking
medical care for bruising, shortness of breath, and exhaustion.
Her blood disorder resulted in
alterations that impacted other body systems, including her
respiratory system (UW Health,
2012). Since the heart and the lungs rely so heavily on the
blood, it is important that
hematological disorders are quickly identified and managed.
This week, as you focus on hematological disorders commonly
presented to advanced
practice nurses, you examine the pathophysiology of anemia.
You also explore the
impact of patient factors on anemic disorders.
Reference
Prochnow, C. (n.d.). Restoring hope: A cancer patient shares
her story. Retrieved September 11, 2012, from
http://www.uwhealth.org/uw-carbone-
cancer-center/restoring-hope-a-cancer-patient-shares-her-
story/20371
Learning Objectives
Students will:
iron deficiency anemia to

9. the pathophysiology of other
types of anemia
related to alterations of the
hematological system
Photo Credit: JPC-PROD/iStock/Getty Images Plus/Getty
images
Learning Resources
Required Readings
Huether, S. E., & McCance, K. L. (2012). Understanding
pathophysiology (Laureate custom
ed.). St. Louis, MO: Mosby.
Hematologic
System”
This chapter examines components of the hematologic system,
development of blood cells,
mechanisms of hemostasis, and hematologic value changes in
pediatrics and geriatrics. It also
focuses on common blood tests for hematologic disorders.
This chapter focuses on common alterations of hematologic
function, including alterations of
erythrocyte function, leukocyte function, lymphoid function,
splenic function, platelets, and
coagulation.
Children”
Unit 5

10. Student Name_______________________
Individual Project 5B Form
Complete the following data taken from the condensed income
statements for merchandising Companies X, Y, and Z.
Company X
Company Y
Company Z
Net income
185
???
40
Sales
???
560
625
Gross profit
335
???
250
Operating expenses
???
179
???
Cost of merchandise sold
450
275
???
Unit 5
Student Name_______________________

11. Individual Project 45 Form
Description
Debit
Credit
A.
B.

12. C.
D.