SlideShare a Scribd company logo
1 of 22
SAMPLE OF MARKETING
CONSULTING WORK AND
PRESENTATION WRITING FOR
MARKETING PROFESSIONAL &
BUSINESS CONSULTANT –
Clifford M. Thornton
Mobile: 267-524-7144
Email: clifford.thornton@gmail.com
ARTERY REPAIR SYSTEMARTERY REPAIR SYSTEM
Bio-Medical Company
This presentation was researched, planned, and written by Clifford M. Thornton
Mobile: 267-524-7144 Email: clifford.thornton@gmail.com
• Coronary artery disease (CAD) is the development of atherosclerotic lesions in their
coronary arteries. This is frequently treated with percutaneous intervention (PCI),
which usually involves balloon angioplasty and stent implantation. The
angioplasty procedure works to clear the artery by compacting the plaque and the
stent serves as a scaffold to support and re-enforce the artery, thereby keeping it
open to allow continuous blood-flow.
Key statistics:
• Cardiovascular disease is the leading global cause of death, accounting for 17.3
million deaths per year, a number that is expected to grow to more than 23.6
million by 2030.
• Cardiovascular disease is the No. 1 cause of death in the United States. Over
2,100 Americans die of cardiovascular disease each day, an average of one death
every 40 seconds.
• After age 40, about 50% of men and one-third of women can expect to have
coronary artery disease. This can rapidly evolve into a life-debilitating or life-
threatening condition.
• By 2030, the American Heart Association (AHA) estimates that 40.5% of the US
population will have some form of CVD, with direct costs estimated at $818 billion.
The Problem: Coronary artery disease is the leading
cause of morbidity and mortality in the world.
Coronary stenting is a ubiquitous, clinically accepted
and routinely used procedure to treat it. Drug-eluting
coronary stents (DES) is now the “Gold Standard” in
cardiovascular care.
• Coronary artery disease (CAD) is the development of atherosclerotic plaque in the human
coronary arteries; these arteries supply the heart itself with oxygen-rich, life-supporting
blood. A human being can only live about 3 minutes without this continuous blood-
flow. Which is why time is of the essence for this condition and procedure.
• CAD is frequently treated with percutaneous intervention (PCI), which usually involves
balloon angioplasty and stent implantation. The angioplasty procedure works to clear
the artery by compacting the plaque and the stent serves as a scaffold to support and re-
enforce the artery, thereby keeping it open to allow continuous blood-flow.
• A small mesh tube called a stent or bare-metal stent (BMS) is usually placed in the newly
widened part of the artery. The stent holds up the artery and lowers the risk of the artery
re-narrowing. Some stents, called drug-eluting stents (DES), are coated with medicines that
are slowly and continuously released into the artery. DESs are now the standard care.
What is a coronary stent and how is it placed or
implanted in the coronary arteries?
Coronary (Balloon) Angioplasty Coronary Stent Implant Primary drugs used
in drug-eluting stents
(DES):
•Everolimus, a
derivative of sirolimus;
serves as an
immunosuppresant
•Sirolimus also known
as rapamycin which are
produced by the
bacterium streptomyces
hygroscopicus; serves
as an
immunosuppresant
Over 1 million angioplasty procedures performed in U.S. per year and
approximately 454,000 stent implants (45% of procedures) per year.
The evolution of interventional cardiology and
related balloon angioplasty and coronary stent
placement has greatly benefited patients, however
interventional cardiologists still seek “the perfect
stent”.
Near-Future: Bio-Compatible stents
will mark the 5th
Revolution in
cardiology as it will herald a new era
given its untethered, and hence
extremely versatile function and
also offers the precision of robotic-
assisted surgery (RAS).
The Solution: Artery Repair Apparatus or
biocompatible-stent, fabricated from bio-compatible
(assembled from nano-scale elements), semiconductor
elements, will be the 5th
Revolution in
cardiovascular care, treating complex occlusions and
vessel aneurysms in a way that was not clinically
possible before.
“Sub-12-French devices negating the need for a surgical cutdown (i.e. when the vein is
exposed surgically) could be marketed and sold to a wider customer base.”
•Control guidance of the stents is enabled by the use of Nuclear Magnetic Imaging
technology- ability to reach capillaries in the brain & lower extremities
•This invention has several advantages over prior angioplasty and stenting
technologies, such as being untethered, 100% image guided, and benefits from
the precision of Robotic Assisted Surgery (RAS), which is fully integrated into it.
•Will place endovascular grafts within the human body to the effect of facilitating rapid
delivery (critical in the case of Thoracic Aortic Aneurysms (TAA) and Abdominal Aortic
Aneurysms (AAA)) of a fused stent (patch).
•The stent will be manufactured from bio-compatible semiconductor cells, which will
be used to repair weakened human vessels such as arteries and veins.
•By repairing and supporting weakened artery walls, aneurysms and their clinical
manifestations can be prevented.
•Upon assembly of the stent, this innovative process will detect, control, position,
and fuse the stent(s) by means of Nuclear Magnetic Imaging.
Stent Device (AARA)
Endovascular Grafting Stent Fabricated by
Apparatus & Procedure Cells - Customize
Sizes & Shapes
Implanted Stent –
Nuclear Magnetic Cells Manufactured
Resonance (NMR) from Bio-Compatible
Technology Controls Semiconductor Cells
Movement of the Stent
Present Methods
Reinforce Weakened or Require Expert
Abnormally Dilated Vessels Surgeons
Stent Device (AARA)
• Repair weakened arteries, vein walls, or other human
body vessels
• Reinforce artery and vein walls
• Utilizes resilient flexible substance inert to bodily
fluids
• Stents are adjustable & expandable
• Based on the radio frequency (RF)
• Can be made smaller or larger (in order to accommodate
vessel size and structure, allowing for ideal placement and
implantation)
• Controlled by magnetic properties, which is very precise
The Automated Artery Repair Apparatus (AARA) has
several advantages over existing stent and vascular graft
technologies. It will be a game-changer, as its robotic
assisted surgery capabilities are analogous to the
automobile revolution of driverless cars.
“Advances in robotic surgery and hybrid endovascular and open surgery
techniques will open new frontiers for surgeons.”
Clinical Challenge Angioplasty-Placed Stents Automated Artery Repair Apparatus (AARA)
Angioplasty fails to adequately open
an artery
Stent must be put in-place by the guidewire, but
determining the right-size French catheter takes
time (trial & error).
Since the AARA is deployed directly into the
blood-stream and does not require wire
determination, the stent can be quickly and
efficiently deployed to the effected site
Traditional stents are susceptible to
stent thrombosis and in-stent
restenosis (ISR); there is a 5%
incidence of ISR with drug-eluting
stents and 20-30% with bare-metal
stents. ISR is associated with
significant morbidity.
Drug-eluting stents are marketed to reduce the
thrombosis risk, but risk of in-stent restenosis
persists.
The compound materials which AARA will be
constructed from will resist thrombus formation;
in-stent restenosis of the biocompatible stents is
very unlikely given its nanoscale.
Endothelial (artery wall) Damage
and smooth muscle cell necrosis
(death of cells) and neo-intimal
hyperplasia
Today’s stents have better recoil, allowing for
better placement and image-guided placement
(OCT, IVUS, MRI), however it is not done
routinely; only in a minority of procedures.
AARA placement will be very precise by the
employment of Robotic Assisted Surgery (RAS)
and MRI image-guidance will be used 100% of the
time as it is integrated into the system.
Placement of stents into diabetic
patient presents certain obstacles
and complex decisions
Patients with Diabetes Mellitus may have to
comply with a dual-anti-platelet therapy (DAPT)
and have higher rates of ISR.
The AARA will be developed to address the
diabetic patient; the risk of ISR is negligible.
Difficult-to-stent anatomical areas
such as bifurcations
Placement of BMSs and DESs are difficult in
tortuous arteries and bifurcations as a
cardiologist must navigate these with the
guidewire
AARA will have no difficulty in reaching the
thinnest arteries and will be able to
circumnavigate any vessel or bifurcation given its
nanoscale size and MRI-guidance.
Stent Obstructions Permanent Metallic Stents can cover side
branches and cause overhang at ostial lesions
and inability to graft the stented segment.
Again, given AARA’s nanoscale size, it will not
cover side branches or overhang.
Continued: Advantages of the Artery Repair System over
traditional, catheter-deployed stent systems.
Clinical Challenge Angioplasty-Placed Stents Automated Artery Repair Apparatus (AARA)
Coronary imaging requires high
temporal resolution to resolve the
constant motion of the respiratory and
cardiac cycles (i.e. diastole/systole)
and high spatial resolution for the
accurate imaging of very small vessels.
Angiography, the standard imaging in an
angioplasty and stent placement procedure, has
limited capabilities and newer modalities
(Intravascular Ultrasound (IVUS), Computed
Tomography (CT), and Magnetic Resonance
Imaging (MRI) are not routinely used.
AARA will ALWAYS employ the use of image-guided
(MRI) stent-placement as it is integrated into the
system and works seamlessly with robotic-assisted
surgery functionality.
Biomechanical Factors: Persistent
non-physiological stresses inside the
arterial wall or abnormal wall shear
stresses (WSS) caused by a stent-
disturbed hemodynamics that
undermine the correct endothelial
functionality.
Traditional stents are prone to these structural and
hemodynamic problems.
AARA, will cause negligible wall shear stress or any
changes in vessel hemodynamics, due to its
nanoscale size.
The most important geometric
characteristics for a stent are: Length,
Diameter, Strut Thickness, and Mesh
Shape
Thinner stent struts, compounds (i.e. cobalt
chromium, platinum chromium) allow for
improved geometric properties, however they are
still limited by their manufacturer’s factory design,
which is static.
The biocompatible stents have almost limitless
ability to conform to the needs of the obstruction
and corresponding vessel; it is incredibly versatile
and adaptable. It can conform to each unique
situation and form accordingly.
Deeper attention is being paid to
complex geometries such as curved
vessels or coronary bifurcations, in
terms of stenting these difficult areas
Thinner-strutted stents, bioresorbable coronary
scaffolds, and image-guidance address this
challenge, but there are physical limits to what
traditional stents can accomplish.
AARA is the perfect solution to stent placement in
these difficult anatomical areas of vessels as both
their nanoscale size, and precise navigation can
effectively stent all of these areas.
Sub-optimal stent deployment leads to
late adverse events
Until advanced image guidance is utilized routinely
with catheter-based stent placement, optimal
stent placement is unlikely when it is not.
Adverse events when utilizing AARA will be
significantly reduced due to precise and effective
stent placement.
Why does the Automated Artery Repair Apparatus employ
Robotic Assisted Surgery (RAS)? What are its advantages
over laparoscopic or traditional surgery?
• The system integrates RAS into its platform because it is more precise, more efficient
and faster to deploy the stent or conduct the artery repair. This technology utilizes
very fast computer processors & related computer software to guide and control
the biocompatible stents or devices. The previous generation of catheters and stents
require skilled surgeons to manually guide & control the devices. With this new system,
the surgeon still directs the surgery, however computer mapping and algorithms offers
optimal navigation routes and placement locations. This represents a huge leap in
technological innovation.
ADVANTAGES OF ROBOTIC ASSISTED SURGERY (RAS):
• Minimally invasive
• Greater visualization
• Precision of the internal surgical work
• Augments the skills of a surgeon
• Enhanced dexterity: extremely fine & precise movements by the biocompatible stents and their
active functions
• Physician looks at the console versus the patient
• More effective surgery equates, clinically, to easier and shorter recovery period, with fewer
complications
• With the aid of computer intelligence, the visualization of a procedure and the support for
surgical movements is becoming more precise.
• Less pain & blood-loss for the patient
• Quicker patient recovery and related shorter hospital length-of-stay (LOS)
• Integrated Surgery: integrate anatomic data (MRI, CT, US); this means better guidance
Worldwide Stent Market Size: Coronary &
Vascular Stents: World demand for stents to treat
atherosclerosis is growing, especially in emerging
markets (i.e. India, China, South America) due to a
rising prevalence of cardiovascular disease, an aging
population, and further penetration in emerging
markets.
• The global interventional cardiology and peripheral vascular devices market is expected to reach
$26.72 Billion by 2019 from $18.73 Billion in 2014, at a CAGR of 7.4% from 2014 to 2019.
• U.S. market for coronary stents is forecast to be $5.61 billion by 2020 (BMS/DES)
• Key Emerging Market Sales of coronary stents are $2.3 Billion with projected 7% annual growth
• Global stent sales are forecast to grow at nearly double-digit rates between through 2021
• 59.6% of stent market is comprised of coronary stent sales
Coronary
Stents
The Worldwide market share for coronary stents is
concentrated between Abbott Laboratories, Boston
Scientific, and Medtronic, however some new entrants
with cutting-edge solutions are entering the fray and are
pushing the boundaries in stent technology and making
breakthrough Innovations. These innovations include
hybrid (drug-eluting and biodegradable) stents,
bioresorbable coronary scaffolds, and proprietary anti-
platelet drugs, such as Biosensor’s Biolimus A9.
Note: Others include: Microport Scientific (China)-
www.microport.com, Biotronik, Inc. (Germany)-
www.biotronik.com, Sahajanand Medical Technologies
(India)-www.smtpl.com, Elixir Medical Corp. (U.S.)-
www.elixirmedical.com, and Stentys S.A. (France)-
www.stentys.com
Worldwide Coronary Stent Sales by Manufacturer
In Millions of US$
 
Abbott Laboratories (U.S.)-
www.abbott.com
Boston Scientific (U.S.)-
www.bostonscientific.com
Medtronic Corp. (U.S.)-
www.medtronic.com
Terumo Medical (Japan)-
www.terumomedical.com
Biosensors (Japan &
Singapore)-
www.biosensors.com
Others
2013 Sales                                     1,375                                            815                                   1,780                                         346                                 336           784 
2014 Sales                                     1,463                                            865                                   1,740                                         367                                 324           933 
% Change 6.0% 5.8% -2.3% 5.7% -3.7% 16.0%
Total Worldwide Market Value (2014) 5,692
As stent technology has evolved, entrenched players as
well as new entrants have developed a wide-range of
stent product systems. Drug-eluting stents (DES) are
now the “gold-standard” of care, however a market
still exists for bare-metal stents (BMS). Along with BMS
and DES, both entrenched and new players are
marketing a plethora of innovative and very clinically
advanced stent solutions.
Coronary Stent Products by Manufacturer
 
Abbott
Laboratories
Boston Scientific Medtronic Corp.
Terumo
Medical
Biosensors Microport Scientific Biotronik Inc.
Sahajanand
Medical
Technologies
Elixir Medical
Corp.
Stentys S.A.
Bare Metal
Stents (BMS)
Promus Premier
Rebel (PtCr alloy), 
VeriFLEX
Integrity BMS     Tango, Mustang, Waltz  
Flexinnium, 
Tetriniun (Cobalt 
Chromium Stent)
 
Self-opposing 
BMS- currently 
in FDA study
Drug-Eluting
Stents (DES)-
Everolimus,
Sirolimus,
Rapamycin
Xience Alpine
Promus Element, 
Promus Premier 
(Platinum 
Chromium)
Resolute Integrity- 
1st and only FDA 
approved DES for 
Diabetes
Ultimaster 
(Sirolimus)
 
Firehawk (Rapamycin)-
World's 1st & only target 
eluting stent (TES), 
lowest drug-dosage
 
Supraflex, 
Vactaflex, 
Indolimus 
(Sirolimus)
DESyne   
Drug-Eluting
Stents (DES)-
Paclitaxel
  ION                
Biodegradable
Polymer Stents
  Synergy     S-Stent    
EveroFlex 
(Everolimus)
DESyne BD- 
achieves bare-
metal surface 
in 6-9 mos.
 
Coronary Grafts GraftMaster RX                  
Polymer
Bioresorbable
Vascular Scaffold
(BVS)
Absorb BVS     ART  
Firesorb Bioresorbable 
Target Eluting Coronary 
Scaffold System 
(Rapamycin)- First-in-
Man
DREAMS 
(magnesium 
alloy)
  DESolve BRS  
• Vascular stents are required and implanted for the same reason that coronary stents are, that
is to support an artery like a scaffold, once balloon angioplasty has been performed; the
clinical indication is usually atherosclerotic plaque obstructing the artery. Also, just
as drug-eluting coronary stents are deployed, to reduce endothelial damage and speed-up
recover, vascular drug-eluting stents are now available.
• Vascular artery occlusions can have serious implications for a patient including limb
malfunction and poor limb vascularization, which can possibly lead to limb amputation, it can
cause the patient severe pain and difficulty or inability to walk, and it can also effect one’s
venous return or blood-flow, negatively impacting their heart’s filling (diastolic function).
• Vascular stents are placed and implanted just as coronary stents are, with vascular
angioplasty guidewires and balloons, however specified for certain vascular areas; this can
include carotid, iliac, and femoral (above-the-knee (suprapopliteal) or below-the-knee
(infrapopliteal). There are also vascular stents for biliaries, bronchial, renal, and urinary
vessels.
• Vascular grafts are usually needed when a major vascular artery, such as the thoracic aorta
(TA), abdominal aorta (AA) shows evidence of an aneurysm (detected by X-ray, ultrasound
(US), computed tomography (CT), or magnetic resonance imaging (MRI). The risk of a
thoracic (TAA) or abdominal aortic aneurysm (AAA) rupturing can be death (AAAs are one of
the top 10 causes of death for Men in the U.S.).
• Vascular grafts are placed surgically and serve to support the artery, also like a scaffold, but
cover a larger anatomical area than stents, since these arteries are relatively large (around 3.0
– 4.0 CM in diameter). These grafts are then visible in future medical imaging tests.
What clinical situations necessitate implantation
of a vascular stent or endovascular graft? How are
vascular stents guided & implanted?
The worldwide Endovascular Graft Devices market is
experiencing very healthy growth as more interventional
options are available to patients with this potentially life-
threatening condition. Also, the occurrence of aortic
aneurysms is increasing worldwide.
• The Worldwide Aortic Stent Grafts Market will be worth $1.9 Billion by 2020 while
growing at a CAGR of 9.5% to 2018 and 6.7% to 2020.
• The U.S. EVAR endograft market, which represents over 50% of the worldwide
market, is currently valued at about $760 million with a CAGR of 8% per year.
The worldwide vascular stent & endovascular
grafting market is experiencing faster growth (around
7-8% annually) as compared with the coronary stent
market (4-5% annually). This brisk growth is being
driven by greater awareness and detection of
vascular disease and its implications, new medical
technology to address it (such as below-the-knee
angioplasty & stents), and more disposable income
to pay for these treatments.
Worldwide Vascular Angioplasty, Stent & Endovascular Graft Sales by Manufacturer
In Millions of US$
 
Abbott Laboratories
(U.S.)-
www.abbott.com
Boston Scientific (U.S.)-
www.bostonscientific.com
Medtronic Corp. (U.S.)-
www.medtronic.com
C.R. Bard, Inc. (U.S.)-
www.crbard.com
Others
2013 Sales                                469                                             809                                    867                                    830                                    370 
2014 Sales                                527                                             850                                    895                                    928                                    407 
% Change 6.0% 4.8% 3.1% 10.6% 9.2%
Total Worldwide Market Value (2014) 3,608
Note: Others include: Terumo Medical (Japan)-www.terumomedical.com, Microport Scientific (China)-
www.microport.com, and W.L. Gore & Associates (U.S.)-www.gore.com
The lion’s share of the vascular stent market is
concentrated amongst the same major players in the
coronary stent market, however Boston Scientific,
Medtronic, and Microport Scientific market the most
diverse and comprehensive product lines of vascular stent
& endovascular grafting solutions. Additionally vascular
stent solutions evolve with drug-eluting vascular stents,
more versatile vascular angioplasty and stent placement,
as well as endovascular grafts for aortic bifurcations.
Vascular Stent & Endovascular Graft Products by Manufacturer
 
Abbott
Laboratories
Boston Scientific Medtronic Corp. Terumo Medical Biosensors Microport Scientific Biotronik Inc.
Vascular Stent -
Carotid
RX Acculink- 1st-to-
market for carotid 
stents
WALLSTENT-
Monorail 
Endoprosthesis
         
Vascular Stent-
Iliac
Omnilink Elite- 
expandable stent 
system
EPIC-self-expanding 
stent system
         
Vascular Stent-
Femoral Arteries
 
Innova-self-
expanding stent 
system
 
Misago RX-self-expanding 
peripheral stent (for 
superficial femoral artery & 
proximal popliteal artery)
Biomatrix Flex-
Infrapopliteal
 
Astron-Lower-limb 
arteries (Femoropopliteal 
& Infrapopliteal), Astron 
Pulsar - Gold-plated, 
Pulsar-35 (Suprafemoral)
Endovascular
Grafts (AAAs &
TAAs)
Absolute Pro- self-
expanding stent 
system
WALLSTENT-
Endoprosthesis
Endurant II-AAA, 
Valiant-TAA, Talent-
TAA 
   
Hercules T-
Transthoracic, 
Hercules B-
Bifurcated Graft 
System, Aegis 
Bifurcated Stent 
Graft System 
 
Vascular Drug-
Eluting Stents
       
Biomatrix Flex-
Infrapopliteal 
(Biolimus A9-
proprietary)
   
• While stent technology has become very effective for treating patients suffering from
cardiovascular disease, and even raising the bar in terms of outcomes, many clinical challenges
persist. These include speed-to-repair, complex lesions, treating complete coronary
blockages, and making image-guided stent placement routine, which today IT IS NOT;
one of the keys to long-term stent treatment success.
Summary: Why Zurn’s AARA or Biocompatible Stent is Much Better!
• Precise stent deployment: Robotic Assisted Surgery is fully-integrated into the AARA.
• Limitless anatomical placement of Bio-compatible stents: Stenting will be possible &
effective in the most difficult anatomical areas such as small brain capillaries, below-the-knee
(infrapopliteal) arteries, tortuous vessels, and vessel bifurcations; this will provide new
treatment options for patients suffering from stroke-related diseases and limb ischemia, both
of which can be life-threatening.
• Faster Time-to-Treatment (“Time is Brain”): The AARA can be deployed more quickly than
wire-catheter-based stent systems, since they are directly injected into the blood-stream and
navigated to the lesion immediately; their untethered characteristic negates the need to
scale a guidewire to a French Catheter, which can delay stent deployment and care.
• Faster Patient Recovery & Healthcare Cost Savings: Better stent placement offered by
AARA means significantly reduced adverse effects (lower risk of thrombus formation, less
endothelial damage), and hence a shorter hospital length-of-stay (LOS) for the patient.
The Artery Repair Apparatus is a Superior Solution
over existing stent technologies. It will come to be
known as a disruptive clinical solution, as it takes a
REVOLUTIONARY approach to vessel support and
repair. Namely, the integration of Robotic Assisted
Surgery (RAS) and its many accompanying
advantages & benefits.
Professional Background:
Clifford M. Thornton, Marketing
& Executive Support
• Highly competent and experienced in Cardiac Diagnostics (specialized in echocardiography / cardiac
sonography) and related knowledge on heart diseases (including cardiomyopathies)
• Certified Cardiovascular Technologist, Sanford-Brown Institute, 2004
• Registered Diagnostic Cardiac Sonographer (RDCS) – American Registry of Diagnostic Medical Sonographers (ARDMS) – Retired
status (was actively scanning from 2006 – 2014)
• Performed approximately 5,000 adult transthoracic echocardiograms (TTE) and 2,000 adult transesophageal echocardiograms
(TEE) (with performing cardiologist). Quality of studies rated by reading cardiologists most often in the good to excellent range.
• Developed strong and fluid working relationships with interventional and non-interventional cardiologists such as Michael S. Flynn,
M.D., FACC (was listed in Castle Connolly’s America’s Top Doctors – 2012-2013) and Julian Javier, M.D., Co-founder of Vascular
Device Partners (conducts first-in-Man medical device investigative studies).
• Successfully served as an echocardiography teacher & instructor for 4 years at a healthcare training school, helping students pass
their echo board exams and receiving very positive feedback from students.
• Worked independently and successfully as a contract echocardiographer for private cardiology practices, internist clinics, and
mobile ultrasound firms (in New Jersey, New York, Florida, Maryland, North Carolina, and Hawaii).
• Prior to entering the cardiac diagnostics field, acquired Fortune 500 experience as a Program
Manager and Business Analyst
• As a Program Manager for Lucent Technologies and then Avaya (was employed by them during the Avaya spin-off), served as an
integral member of the core teams for the product launches of mid-sized business communications systems, Merlin Magix R2.0
and IP Office R1.0.
• Served as a Business Analyst in MediaOne Group’s Market Strategy Development (MSD) Team, supporting directors on high-level
business plans for high-speed internet over coaxial cable, video-on-demand (VOD), and a FCC auction for Local Multi-Point
Distribution (LMDS) service or microwave-based wireless broadband communications. MediaOne Group evolved from USWest
Media Group and has since been acquired by Comcast Corporation.
• Served honorably in the United States Navy Reserve from 2002 – 2010 (in IRR from 2007 – 2010).
Voted Sailor of Quarter (April – June, 2004) for unit CART B-104, NWS Earle, Colts Neck, NJ
• Other academic credentials: B.S. Business Administration, Major: Marketing, New York University,
Leonard N. Stern School of Business, 1997, Made Dean’s List in 1996 (under Dean Frederick Choi)
Sources utilized for this presentation
• “Modeling Drug Release in Cardiovascular Eluting Stents”, Grassi G., Grassi M., Pontrelli G.,
Teresi L. in: Modelling Cardiovascular System and Mechanical Circulatory Support, Claudio
De Lazzari Ed., CNR, pp. 135-151, 2007
• University of Michigan Health System – Coronary, http://www.med.umich.edu/cardiac-
surgery/patient/adult/adultcandt/coronary_angioplasty.shtml
• Medscape: Peripheral Vascular Stent Insertion, Author: Dale K Mueller, MD; Chief Editor:
Karlheinz Peter, MD, PhD, http://emedicine.medscape.com/article/1839716-overview
• “What is robotic surgery with the da Vinci Surgery system?”,
http://www.laparoscopic.md/robotic
• University of Cincinnati Health, http://uchealth.com/services/robotic-surgery/patient-
information/benefits/
• Mayo Clinic, “Robotic Surgery”, http://www.mayoclinic.org/tests-procedures/robotic-
surgery/basics/definition/prc-20013988
• Aortic Stent Grafts – Global Analysis and Market Forecasts, MediPoint,
http://www.reportsnreports.com/reports/300725-medipoint-aortic-stent-grafts-global-
analysis-and-market-forecasts.html
• “EVAR Update: Competitors Stake Their Ground In a High-Growth Space”, Mary Thompson,
MedTech Insights, April 2013, http://www.nea.com/uploads/files/employee/TriVascular.pdf
• “Endovascular Repair of Aortic Disease: A Venture Capital Perspective”, Seminars in
Interventional Radiology, 2009 Mar; 26(1): 56–66.,
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036456/
• Interventional Cardiology & Peripheral Vascular Devices Market (Embolic Protection, Chronic
Total Occlusion, Atherectomy, Thrombectomy, IVUS, Angiography Catheters, EVAR Stent
Grafts, IVC Filters, Stents, Balloons and Accessories) - Forecasts to 2019”,
MarketsandMarkets
• “REBEL Bare Metal Stent Could Be A $200 Million Opportunity For Boston Scientific”, Forbes,
March 21, 2014
Sources utilized for this presentation
(Continued)
• CORONARY STENTS – GLOBAL ANALYSIS AND MARKET FORECASTS, GlobalData – MediPoint,
November 2014
• “Coronary stents: historical development, current status and future directions”, Oxford Journals,
February 2013
• MediPoint: Coronary Stents - US Analysis and Market Forecasts, November 2014
• “Coronary Stents and Noncardiac Surgery: Current Clinical Challenges and Conundrums”,
http://onlinelibrary.wiley.com/doi/10.1111/j.1751-7141.2009.00044.x/full
• “Modeling Stented Coronary Arteries: Where We are, Where to Go”, Annals of Biomedical
Engineering, July 2013, Volume 41, Issue 7, pp 1428-1444,
http://link.springer.com/article/10.1007/s10439-012-0681-6
• “Novel design of drug delivery in stented arteries: a numerical comparative study”, Math Biosci
Eng. 2009 Jul;6(3):493-508, http://www.ncbi.nlm.nih.gov/pubmed/19566122
• “Below-the-knee Interventions”, Cardiovascular Intervental Radioly, 2013, 36:302–311,
http://www.cirse.org/files/files/SOP/2013/SoP_BTK%20Interventions_vanOverhagen_2013.pdf
• Abbott Laboratories, www.abbott.com, 2014 Annual Report
• Boston Scientific, www.bostonscientific.com, 2014 Annual Report
• Medtronic Corporation, www.Medtronic.com, 2014 Annual Report
• Terumo Medical, www.terumomedical.com, 2014 Annual Report
• “Elixir Medical’s Contrarian Play in Cardiology: Go Bioresorbable or Go Home”, The MedTech
Strategist, June 30, 2015, Vol. 2, No. 12

More Related Content

What's hot

Chronic Total Occlusions: The Road Less Traveled
Chronic Total Occlusions: The Road Less TraveledChronic Total Occlusions: The Road Less Traveled
Chronic Total Occlusions: The Road Less TraveledAllina Health
 
Future of cardiology
Future of cardiologyFuture of cardiology
Future of cardiologymkocierz
 
Optimal planning for a successful CTO recanalization: new algorithms
Optimal planning for a successful CTO recanalization: new algorithmsOptimal planning for a successful CTO recanalization: new algorithms
Optimal planning for a successful CTO recanalization: new algorithmsEuro CTO Club
 
Alexandre Avran - Angiogram-how to record, analyseand prepare to the interven...
Alexandre Avran - Angiogram-how to record, analyseand prepare to the interven...Alexandre Avran - Angiogram-how to record, analyseand prepare to the interven...
Alexandre Avran - Angiogram-how to record, analyseand prepare to the interven...Euro CTO Club
 
CTO PCI today – A summary of recent publications
CTO PCI today – A summary of recent publicationsCTO PCI today – A summary of recent publications
CTO PCI today – A summary of recent publicationsEuro CTO Club
 
Intracoronary optical coherence tomography
Intracoronary optical coherence tomographyIntracoronary optical coherence tomography
Intracoronary optical coherence tomographyRamachandra Barik
 
Intravascular lithotripsy: not an eccentric option for eccentric calcium
Intravascular lithotripsy: not an eccentric option for eccentric calciumIntravascular lithotripsy: not an eccentric option for eccentric calcium
Intravascular lithotripsy: not an eccentric option for eccentric calciumEuro CTO Club
 
Antegrade approach – how to start? Views of a minimalist and a maximalist poi...
Antegrade approach – how to start? Views of a minimalist and a maximalist poi...Antegrade approach – how to start? Views of a minimalist and a maximalist poi...
Antegrade approach – how to start? Views of a minimalist and a maximalist poi...Euro CTO Club
 
External aortic root support in Marfan syndrome
External aortic root support in Marfan syndromeExternal aortic root support in Marfan syndrome
External aortic root support in Marfan syndromeYasoba Atukorale
 
Friday 0920 - mashayekhi - case1
Friday 0920 - mashayekhi - case1Friday 0920 - mashayekhi - case1
Friday 0920 - mashayekhi - case1Euro CTO Club
 
Innovation trends and Opportunities in safety critical coronary artery stents
Innovation trends and Opportunities in safety critical coronary artery stentsInnovation trends and Opportunities in safety critical coronary artery stents
Innovation trends and Opportunities in safety critical coronary artery stentsRamanan Lakshminarayanan
 
Percutaneous mitral valve interventions (repair)
Percutaneous mitral valve interventions (repair) Percutaneous mitral valve interventions (repair)
Percutaneous mitral valve interventions (repair) ajay pratap singh
 
Retrograde approach Step by Step
Retrograde approach Step by StepRetrograde approach Step by Step
Retrograde approach Step by StepEuro CTO Club
 
Friday 1758 – goicolea pathology of cto
Friday 1758 – goicolea   pathology of ctoFriday 1758 – goicolea   pathology of cto
Friday 1758 – goicolea pathology of ctoEuro CTO Club
 
Intracoronary Imaging – when to use, how to use and how to interpret the images
Intracoronary Imaging – when to use, how to use and how to interpret the imagesIntracoronary Imaging – when to use, how to use and how to interpret the images
Intracoronary Imaging – when to use, how to use and how to interpret the imagesEuro CTO Club
 
Endovascular neurosurgery
Endovascular neurosurgeryEndovascular neurosurgery
Endovascular neurosurgeryMukhtar Khan
 
Emmanouil S. Brilakis - Antegrade dissection re-entry step by step
Emmanouil S. Brilakis - Antegrade dissection re-entry step by stepEmmanouil S. Brilakis - Antegrade dissection re-entry step by step
Emmanouil S. Brilakis - Antegrade dissection re-entry step by stepEuro CTO Club
 
Imre UNGI - Long-term out come of DES in CTOs
Imre UNGI - Long-term out come of DES in CTOsImre UNGI - Long-term out come of DES in CTOs
Imre UNGI - Long-term out come of DES in CTOsEuro CTO Club
 

What's hot (20)

Chronic Total Occlusions: The Road Less Traveled
Chronic Total Occlusions: The Road Less TraveledChronic Total Occlusions: The Road Less Traveled
Chronic Total Occlusions: The Road Less Traveled
 
Future of cardiology
Future of cardiologyFuture of cardiology
Future of cardiology
 
Optimal planning for a successful CTO recanalization: new algorithms
Optimal planning for a successful CTO recanalization: new algorithmsOptimal planning for a successful CTO recanalization: new algorithms
Optimal planning for a successful CTO recanalization: new algorithms
 
Alexandre Avran - Angiogram-how to record, analyseand prepare to the interven...
Alexandre Avran - Angiogram-how to record, analyseand prepare to the interven...Alexandre Avran - Angiogram-how to record, analyseand prepare to the interven...
Alexandre Avran - Angiogram-how to record, analyseand prepare to the interven...
 
CTO PCI today – A summary of recent publications
CTO PCI today – A summary of recent publicationsCTO PCI today – A summary of recent publications
CTO PCI today – A summary of recent publications
 
Intracoronary optical coherence tomography
Intracoronary optical coherence tomographyIntracoronary optical coherence tomography
Intracoronary optical coherence tomography
 
Intravascular lithotripsy: not an eccentric option for eccentric calcium
Intravascular lithotripsy: not an eccentric option for eccentric calciumIntravascular lithotripsy: not an eccentric option for eccentric calcium
Intravascular lithotripsy: not an eccentric option for eccentric calcium
 
Antegrade approach – how to start? Views of a minimalist and a maximalist poi...
Antegrade approach – how to start? Views of a minimalist and a maximalist poi...Antegrade approach – how to start? Views of a minimalist and a maximalist poi...
Antegrade approach – how to start? Views of a minimalist and a maximalist poi...
 
External aortic root support in Marfan syndrome
External aortic root support in Marfan syndromeExternal aortic root support in Marfan syndrome
External aortic root support in Marfan syndrome
 
ACC: Slides from ORBIT II
ACC: Slides from ORBIT II ACC: Slides from ORBIT II
ACC: Slides from ORBIT II
 
Friday 0920 - mashayekhi - case1
Friday 0920 - mashayekhi - case1Friday 0920 - mashayekhi - case1
Friday 0920 - mashayekhi - case1
 
Innovation trends and Opportunities in safety critical coronary artery stents
Innovation trends and Opportunities in safety critical coronary artery stentsInnovation trends and Opportunities in safety critical coronary artery stents
Innovation trends and Opportunities in safety critical coronary artery stents
 
Percutaneous mitral valve interventions (repair)
Percutaneous mitral valve interventions (repair) Percutaneous mitral valve interventions (repair)
Percutaneous mitral valve interventions (repair)
 
Retrograde approach Step by Step
Retrograde approach Step by StepRetrograde approach Step by Step
Retrograde approach Step by Step
 
Friday 1758 – goicolea pathology of cto
Friday 1758 – goicolea   pathology of ctoFriday 1758 – goicolea   pathology of cto
Friday 1758 – goicolea pathology of cto
 
Intracoronary Imaging – when to use, how to use and how to interpret the images
Intracoronary Imaging – when to use, how to use and how to interpret the imagesIntracoronary Imaging – when to use, how to use and how to interpret the images
Intracoronary Imaging – when to use, how to use and how to interpret the images
 
Endovascular neurosurgery
Endovascular neurosurgeryEndovascular neurosurgery
Endovascular neurosurgery
 
Emmanouil S. Brilakis - Antegrade dissection re-entry step by step
Emmanouil S. Brilakis - Antegrade dissection re-entry step by stepEmmanouil S. Brilakis - Antegrade dissection re-entry step by step
Emmanouil S. Brilakis - Antegrade dissection re-entry step by step
 
Imre UNGI - Long-term out come of DES in CTOs
Imre UNGI - Long-term out come of DES in CTOsImre UNGI - Long-term out come of DES in CTOs
Imre UNGI - Long-term out come of DES in CTOs
 
TEVAR
TEVARTEVAR
TEVAR
 

Similar to Thornton clifford sample_consulting

A Review of Atherectomy in Peripheral Arterial Disease
A Review of Atherectomy in Peripheral Arterial DiseaseA Review of Atherectomy in Peripheral Arterial Disease
A Review of Atherectomy in Peripheral Arterial Diseaseasclepiuspdfs
 
Coronary Ostial stenting techniques:Current status
Coronary Ostial stenting techniques:Current statusCoronary Ostial stenting techniques:Current status
Coronary Ostial stenting techniques:Current statusPawan Ola
 
carotid stenosis and carotid artery stenting- un update
carotid stenosis and carotid artery stenting- un updatecarotid stenosis and carotid artery stenting- un update
carotid stenosis and carotid artery stenting- un updateDr Siva subramaniyan
 
Retrograde coronary chronic total occlusion intervention
Retrograde coronary chronic total occlusion interventionRetrograde coronary chronic total occlusion intervention
Retrograde coronary chronic total occlusion interventionRamachandra Barik
 
Endovascular repair of thoracic and abdominal aortic aneurysms
Endovascular repair of thoracic and abdominal aortic aneurysmsEndovascular repair of thoracic and abdominal aortic aneurysms
Endovascular repair of thoracic and abdominal aortic aneurysmsApollo Hospitals
 
Coronary aneurysm: At a glance and Management.pptx
Coronary aneurysm: At a glance and Management.pptxCoronary aneurysm: At a glance and Management.pptx
Coronary aneurysm: At a glance and Management.pptxabhishek tiwari
 
Basics you need to know about heart disease and stents
Basics you need to know about heart disease and stentsBasics you need to know about heart disease and stents
Basics you need to know about heart disease and stentsZeena Nackerdien
 
Novel self expanding nitinol carotid stent - dr Krzysztof Milewski
Novel self expanding nitinol carotid stent - dr Krzysztof MilewskiNovel self expanding nitinol carotid stent - dr Krzysztof Milewski
Novel self expanding nitinol carotid stent - dr Krzysztof Milewskipiodof
 
Vascular stents
Vascular stents Vascular stents
Vascular stents Ortal Levi
 
Coronarystents phpapp02
Coronarystents phpapp02Coronarystents phpapp02
Coronarystents phpapp02Saurabh Gupta
 
Intracranial atherosclerotic disease
Intracranial atherosclerotic diseaseIntracranial atherosclerotic disease
Intracranial atherosclerotic diseaseNeurologyKota
 
Problem associated with drug eluting stent
Problem associated with drug eluting stentProblem associated with drug eluting stent
Problem associated with drug eluting stentPRAVEEN GUPTA
 
Carotid stenosis
Carotid stenosisCarotid stenosis
Carotid stenosiskiwaasa
 

Similar to Thornton clifford sample_consulting (20)

A Review of Atherectomy in Peripheral Arterial Disease
A Review of Atherectomy in Peripheral Arterial DiseaseA Review of Atherectomy in Peripheral Arterial Disease
A Review of Atherectomy in Peripheral Arterial Disease
 
Coronary Ostial stenting techniques:Current status
Coronary Ostial stenting techniques:Current statusCoronary Ostial stenting techniques:Current status
Coronary Ostial stenting techniques:Current status
 
carotid stenosis and carotid artery stenting- un update
carotid stenosis and carotid artery stenting- un updatecarotid stenosis and carotid artery stenting- un update
carotid stenosis and carotid artery stenting- un update
 
Retrograde coronary chronic total occlusion intervention
Retrograde coronary chronic total occlusion interventionRetrograde coronary chronic total occlusion intervention
Retrograde coronary chronic total occlusion intervention
 
Ec ic bypass
Ec ic bypassEc ic bypass
Ec ic bypass
 
Cchis march newsletter
Cchis march newsletterCchis march newsletter
Cchis march newsletter
 
Carotid angioplasty
Carotid angioplastyCarotid angioplasty
Carotid angioplasty
 
Endovascular repair of thoracic and abdominal aortic aneurysms
Endovascular repair of thoracic and abdominal aortic aneurysmsEndovascular repair of thoracic and abdominal aortic aneurysms
Endovascular repair of thoracic and abdominal aortic aneurysms
 
Coronary aneurysm: At a glance and Management.pptx
Coronary aneurysm: At a glance and Management.pptxCoronary aneurysm: At a glance and Management.pptx
Coronary aneurysm: At a glance and Management.pptx
 
Heart care
Heart careHeart care
Heart care
 
Basics you need to know about heart disease and stents
Basics you need to know about heart disease and stentsBasics you need to know about heart disease and stents
Basics you need to know about heart disease and stents
 
Novel self expanding nitinol carotid stent - dr Krzysztof Milewski
Novel self expanding nitinol carotid stent - dr Krzysztof MilewskiNovel self expanding nitinol carotid stent - dr Krzysztof Milewski
Novel self expanding nitinol carotid stent - dr Krzysztof Milewski
 
IVL
IVLIVL
IVL
 
MSCT guiding PCI
MSCT guiding PCIMSCT guiding PCI
MSCT guiding PCI
 
Vascular stents
Vascular stents Vascular stents
Vascular stents
 
Coronarystents phpapp02
Coronarystents phpapp02Coronarystents phpapp02
Coronarystents phpapp02
 
Intracranial atherosclerotic disease
Intracranial atherosclerotic diseaseIntracranial atherosclerotic disease
Intracranial atherosclerotic disease
 
What is Carotid Angioplasty
What is Carotid AngioplastyWhat is Carotid Angioplasty
What is Carotid Angioplasty
 
Problem associated with drug eluting stent
Problem associated with drug eluting stentProblem associated with drug eluting stent
Problem associated with drug eluting stent
 
Carotid stenosis
Carotid stenosisCarotid stenosis
Carotid stenosis
 

More from Clifford Thornton

Global innovation magazine_issue10
Global innovation magazine_issue10Global innovation magazine_issue10
Global innovation magazine_issue10Clifford Thornton
 
Zurn drill bit_informational_deck_cmt_12-03-2017
Zurn drill bit_informational_deck_cmt_12-03-2017Zurn drill bit_informational_deck_cmt_12-03-2017
Zurn drill bit_informational_deck_cmt_12-03-2017Clifford Thornton
 
Thornton clifford m_future_of_cardiology_09-01-2017_v4
Thornton clifford m_future_of_cardiology_09-01-2017_v4Thornton clifford m_future_of_cardiology_09-01-2017_v4
Thornton clifford m_future_of_cardiology_09-01-2017_v4Clifford Thornton
 
Clifford thornton spe_600_research_project_final
Clifford thornton spe_600_research_project_finalClifford thornton spe_600_research_project_final
Clifford thornton spe_600_research_project_finalClifford Thornton
 
Thornton lesson plan_1_indian_nations_presentation_10-18-2016_v2
Thornton lesson plan_1_indian_nations_presentation_10-18-2016_v2Thornton lesson plan_1_indian_nations_presentation_10-18-2016_v2
Thornton lesson plan_1_indian_nations_presentation_10-18-2016_v2Clifford Thornton
 
Intro to echo_class_05262015
Intro to echo_class_05262015Intro to echo_class_05262015
Intro to echo_class_05262015Clifford Thornton
 

More from Clifford Thornton (7)

Global innovation magazine_issue10
Global innovation magazine_issue10Global innovation magazine_issue10
Global innovation magazine_issue10
 
Zurn drill bit_informational_deck_cmt_12-03-2017
Zurn drill bit_informational_deck_cmt_12-03-2017Zurn drill bit_informational_deck_cmt_12-03-2017
Zurn drill bit_informational_deck_cmt_12-03-2017
 
Thornton clifford m_future_of_cardiology_09-01-2017_v4
Thornton clifford m_future_of_cardiology_09-01-2017_v4Thornton clifford m_future_of_cardiology_09-01-2017_v4
Thornton clifford m_future_of_cardiology_09-01-2017_v4
 
Clifford thornton spe_600_research_project_final
Clifford thornton spe_600_research_project_finalClifford thornton spe_600_research_project_final
Clifford thornton spe_600_research_project_final
 
Thornton lesson plan_1_indian_nations_presentation_10-18-2016_v2
Thornton lesson plan_1_indian_nations_presentation_10-18-2016_v2Thornton lesson plan_1_indian_nations_presentation_10-18-2016_v2
Thornton lesson plan_1_indian_nations_presentation_10-18-2016_v2
 
Echo class 2_05262015
Echo class 2_05262015Echo class 2_05262015
Echo class 2_05262015
 
Intro to echo_class_05262015
Intro to echo_class_05262015Intro to echo_class_05262015
Intro to echo_class_05262015
 

Recently uploaded

Best Rate (Hyderabad) Call Girls Jahanuma ⟟ 8250192130 ⟟ High Class Call Girl...
Best Rate (Hyderabad) Call Girls Jahanuma ⟟ 8250192130 ⟟ High Class Call Girl...Best Rate (Hyderabad) Call Girls Jahanuma ⟟ 8250192130 ⟟ High Class Call Girl...
Best Rate (Hyderabad) Call Girls Jahanuma ⟟ 8250192130 ⟟ High Class Call Girl...astropune
 
Bangalore Call Girls Hebbal Kempapura Number 7001035870 Meetin With Bangalor...
Bangalore Call Girls Hebbal Kempapura Number 7001035870  Meetin With Bangalor...Bangalore Call Girls Hebbal Kempapura Number 7001035870  Meetin With Bangalor...
Bangalore Call Girls Hebbal Kempapura Number 7001035870 Meetin With Bangalor...narwatsonia7
 
Artifacts in Nuclear Medicine with Identifying and resolving artifacts.
Artifacts in Nuclear Medicine with Identifying and resolving artifacts.Artifacts in Nuclear Medicine with Identifying and resolving artifacts.
Artifacts in Nuclear Medicine with Identifying and resolving artifacts.MiadAlsulami
 
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...Garima Khatri
 
College Call Girls Pune Mira 9907093804 Short 1500 Night 6000 Best call girls...
College Call Girls Pune Mira 9907093804 Short 1500 Night 6000 Best call girls...College Call Girls Pune Mira 9907093804 Short 1500 Night 6000 Best call girls...
College Call Girls Pune Mira 9907093804 Short 1500 Night 6000 Best call girls...Miss joya
 
Russian Call Girls in Pune Riya 9907093804 Short 1500 Night 6000 Best call gi...
Russian Call Girls in Pune Riya 9907093804 Short 1500 Night 6000 Best call gi...Russian Call Girls in Pune Riya 9907093804 Short 1500 Night 6000 Best call gi...
Russian Call Girls in Pune Riya 9907093804 Short 1500 Night 6000 Best call gi...Miss joya
 
Premium Call Girls Cottonpet Whatsapp 7001035870 Independent Escort Service
Premium Call Girls Cottonpet Whatsapp 7001035870 Independent Escort ServicePremium Call Girls Cottonpet Whatsapp 7001035870 Independent Escort Service
Premium Call Girls Cottonpet Whatsapp 7001035870 Independent Escort Servicevidya singh
 
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escorts
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore EscortsCall Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escorts
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escortsvidya singh
 
Call Girls Darjeeling Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Darjeeling Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Darjeeling Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Darjeeling Just Call 9907093804 Top Class Call Girl Service AvailableDipal Arora
 
VIP Russian Call Girls in Varanasi Samaira 8250192130 Independent Escort Serv...
VIP Russian Call Girls in Varanasi Samaira 8250192130 Independent Escort Serv...VIP Russian Call Girls in Varanasi Samaira 8250192130 Independent Escort Serv...
VIP Russian Call Girls in Varanasi Samaira 8250192130 Independent Escort Serv...Neha Kaur
 
Vip Call Girls Anna Salai Chennai 👉 8250192130 ❣️💯 Top Class Girls Available
Vip Call Girls Anna Salai Chennai 👉 8250192130 ❣️💯 Top Class Girls AvailableVip Call Girls Anna Salai Chennai 👉 8250192130 ❣️💯 Top Class Girls Available
Vip Call Girls Anna Salai Chennai 👉 8250192130 ❣️💯 Top Class Girls AvailableNehru place Escorts
 
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls ServiceKesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Servicemakika9823
 
CALL ON ➥9907093804 🔝 Call Girls Baramati ( Pune) Girls Service
CALL ON ➥9907093804 🔝 Call Girls Baramati ( Pune)  Girls ServiceCALL ON ➥9907093804 🔝 Call Girls Baramati ( Pune)  Girls Service
CALL ON ➥9907093804 🔝 Call Girls Baramati ( Pune) Girls ServiceMiss joya
 
Call Girls Cuttack Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Cuttack Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Cuttack Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Cuttack Just Call 9907093804 Top Class Call Girl Service AvailableDipal Arora
 
Call Girls Service Jaipur Grishma WhatsApp ❤8445551418 VIP Call Girls Jaipur
Call Girls Service Jaipur Grishma WhatsApp ❤8445551418 VIP Call Girls JaipurCall Girls Service Jaipur Grishma WhatsApp ❤8445551418 VIP Call Girls Jaipur
Call Girls Service Jaipur Grishma WhatsApp ❤8445551418 VIP Call Girls Jaipurparulsinha
 
VIP Call Girls Indore Kirti 💚😋 9256729539 🚀 Indore Escorts
VIP Call Girls Indore Kirti 💚😋  9256729539 🚀 Indore EscortsVIP Call Girls Indore Kirti 💚😋  9256729539 🚀 Indore Escorts
VIP Call Girls Indore Kirti 💚😋 9256729539 🚀 Indore Escortsaditipandeya
 
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870  Meetin With Bangalore Esc...Bangalore Call Girls Nelamangala Number 7001035870  Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...narwatsonia7
 
Bangalore Call Girls Majestic 📞 9907093804 High Profile Service 100% Safe
Bangalore Call Girls Majestic 📞 9907093804 High Profile Service 100% SafeBangalore Call Girls Majestic 📞 9907093804 High Profile Service 100% Safe
Bangalore Call Girls Majestic 📞 9907093804 High Profile Service 100% Safenarwatsonia7
 

Recently uploaded (20)

Best Rate (Hyderabad) Call Girls Jahanuma ⟟ 8250192130 ⟟ High Class Call Girl...
Best Rate (Hyderabad) Call Girls Jahanuma ⟟ 8250192130 ⟟ High Class Call Girl...Best Rate (Hyderabad) Call Girls Jahanuma ⟟ 8250192130 ⟟ High Class Call Girl...
Best Rate (Hyderabad) Call Girls Jahanuma ⟟ 8250192130 ⟟ High Class Call Girl...
 
Escort Service Call Girls In Sarita Vihar,, 99530°56974 Delhi NCR
Escort Service Call Girls In Sarita Vihar,, 99530°56974 Delhi NCREscort Service Call Girls In Sarita Vihar,, 99530°56974 Delhi NCR
Escort Service Call Girls In Sarita Vihar,, 99530°56974 Delhi NCR
 
Bangalore Call Girls Hebbal Kempapura Number 7001035870 Meetin With Bangalor...
Bangalore Call Girls Hebbal Kempapura Number 7001035870  Meetin With Bangalor...Bangalore Call Girls Hebbal Kempapura Number 7001035870  Meetin With Bangalor...
Bangalore Call Girls Hebbal Kempapura Number 7001035870 Meetin With Bangalor...
 
Artifacts in Nuclear Medicine with Identifying and resolving artifacts.
Artifacts in Nuclear Medicine with Identifying and resolving artifacts.Artifacts in Nuclear Medicine with Identifying and resolving artifacts.
Artifacts in Nuclear Medicine with Identifying and resolving artifacts.
 
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...
 
College Call Girls Pune Mira 9907093804 Short 1500 Night 6000 Best call girls...
College Call Girls Pune Mira 9907093804 Short 1500 Night 6000 Best call girls...College Call Girls Pune Mira 9907093804 Short 1500 Night 6000 Best call girls...
College Call Girls Pune Mira 9907093804 Short 1500 Night 6000 Best call girls...
 
Russian Call Girls in Pune Riya 9907093804 Short 1500 Night 6000 Best call gi...
Russian Call Girls in Pune Riya 9907093804 Short 1500 Night 6000 Best call gi...Russian Call Girls in Pune Riya 9907093804 Short 1500 Night 6000 Best call gi...
Russian Call Girls in Pune Riya 9907093804 Short 1500 Night 6000 Best call gi...
 
Premium Call Girls Cottonpet Whatsapp 7001035870 Independent Escort Service
Premium Call Girls Cottonpet Whatsapp 7001035870 Independent Escort ServicePremium Call Girls Cottonpet Whatsapp 7001035870 Independent Escort Service
Premium Call Girls Cottonpet Whatsapp 7001035870 Independent Escort Service
 
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escorts
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore EscortsCall Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escorts
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escorts
 
Call Girls Darjeeling Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Darjeeling Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Darjeeling Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Darjeeling Just Call 9907093804 Top Class Call Girl Service Available
 
VIP Russian Call Girls in Varanasi Samaira 8250192130 Independent Escort Serv...
VIP Russian Call Girls in Varanasi Samaira 8250192130 Independent Escort Serv...VIP Russian Call Girls in Varanasi Samaira 8250192130 Independent Escort Serv...
VIP Russian Call Girls in Varanasi Samaira 8250192130 Independent Escort Serv...
 
Vip Call Girls Anna Salai Chennai 👉 8250192130 ❣️💯 Top Class Girls Available
Vip Call Girls Anna Salai Chennai 👉 8250192130 ❣️💯 Top Class Girls AvailableVip Call Girls Anna Salai Chennai 👉 8250192130 ❣️💯 Top Class Girls Available
Vip Call Girls Anna Salai Chennai 👉 8250192130 ❣️💯 Top Class Girls Available
 
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls ServiceKesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
 
CALL ON ➥9907093804 🔝 Call Girls Baramati ( Pune) Girls Service
CALL ON ➥9907093804 🔝 Call Girls Baramati ( Pune)  Girls ServiceCALL ON ➥9907093804 🔝 Call Girls Baramati ( Pune)  Girls Service
CALL ON ➥9907093804 🔝 Call Girls Baramati ( Pune) Girls Service
 
Call Girls Cuttack Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Cuttack Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Cuttack Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Cuttack Just Call 9907093804 Top Class Call Girl Service Available
 
Call Girls Service Jaipur Grishma WhatsApp ❤8445551418 VIP Call Girls Jaipur
Call Girls Service Jaipur Grishma WhatsApp ❤8445551418 VIP Call Girls JaipurCall Girls Service Jaipur Grishma WhatsApp ❤8445551418 VIP Call Girls Jaipur
Call Girls Service Jaipur Grishma WhatsApp ❤8445551418 VIP Call Girls Jaipur
 
Russian Call Girls in Delhi Tanvi ➡️ 9711199012 💋📞 Independent Escort Service...
Russian Call Girls in Delhi Tanvi ➡️ 9711199012 💋📞 Independent Escort Service...Russian Call Girls in Delhi Tanvi ➡️ 9711199012 💋📞 Independent Escort Service...
Russian Call Girls in Delhi Tanvi ➡️ 9711199012 💋📞 Independent Escort Service...
 
VIP Call Girls Indore Kirti 💚😋 9256729539 🚀 Indore Escorts
VIP Call Girls Indore Kirti 💚😋  9256729539 🚀 Indore EscortsVIP Call Girls Indore Kirti 💚😋  9256729539 🚀 Indore Escorts
VIP Call Girls Indore Kirti 💚😋 9256729539 🚀 Indore Escorts
 
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870  Meetin With Bangalore Esc...Bangalore Call Girls Nelamangala Number 7001035870  Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...
 
Bangalore Call Girls Majestic 📞 9907093804 High Profile Service 100% Safe
Bangalore Call Girls Majestic 📞 9907093804 High Profile Service 100% SafeBangalore Call Girls Majestic 📞 9907093804 High Profile Service 100% Safe
Bangalore Call Girls Majestic 📞 9907093804 High Profile Service 100% Safe
 

Thornton clifford sample_consulting

  • 1. SAMPLE OF MARKETING CONSULTING WORK AND PRESENTATION WRITING FOR MARKETING PROFESSIONAL & BUSINESS CONSULTANT – Clifford M. Thornton Mobile: 267-524-7144 Email: clifford.thornton@gmail.com
  • 2. ARTERY REPAIR SYSTEMARTERY REPAIR SYSTEM Bio-Medical Company This presentation was researched, planned, and written by Clifford M. Thornton Mobile: 267-524-7144 Email: clifford.thornton@gmail.com
  • 3. • Coronary artery disease (CAD) is the development of atherosclerotic lesions in their coronary arteries. This is frequently treated with percutaneous intervention (PCI), which usually involves balloon angioplasty and stent implantation. The angioplasty procedure works to clear the artery by compacting the plaque and the stent serves as a scaffold to support and re-enforce the artery, thereby keeping it open to allow continuous blood-flow. Key statistics: • Cardiovascular disease is the leading global cause of death, accounting for 17.3 million deaths per year, a number that is expected to grow to more than 23.6 million by 2030. • Cardiovascular disease is the No. 1 cause of death in the United States. Over 2,100 Americans die of cardiovascular disease each day, an average of one death every 40 seconds. • After age 40, about 50% of men and one-third of women can expect to have coronary artery disease. This can rapidly evolve into a life-debilitating or life- threatening condition. • By 2030, the American Heart Association (AHA) estimates that 40.5% of the US population will have some form of CVD, with direct costs estimated at $818 billion. The Problem: Coronary artery disease is the leading cause of morbidity and mortality in the world. Coronary stenting is a ubiquitous, clinically accepted and routinely used procedure to treat it. Drug-eluting coronary stents (DES) is now the “Gold Standard” in cardiovascular care.
  • 4. • Coronary artery disease (CAD) is the development of atherosclerotic plaque in the human coronary arteries; these arteries supply the heart itself with oxygen-rich, life-supporting blood. A human being can only live about 3 minutes without this continuous blood- flow. Which is why time is of the essence for this condition and procedure. • CAD is frequently treated with percutaneous intervention (PCI), which usually involves balloon angioplasty and stent implantation. The angioplasty procedure works to clear the artery by compacting the plaque and the stent serves as a scaffold to support and re- enforce the artery, thereby keeping it open to allow continuous blood-flow. • A small mesh tube called a stent or bare-metal stent (BMS) is usually placed in the newly widened part of the artery. The stent holds up the artery and lowers the risk of the artery re-narrowing. Some stents, called drug-eluting stents (DES), are coated with medicines that are slowly and continuously released into the artery. DESs are now the standard care. What is a coronary stent and how is it placed or implanted in the coronary arteries? Coronary (Balloon) Angioplasty Coronary Stent Implant Primary drugs used in drug-eluting stents (DES): •Everolimus, a derivative of sirolimus; serves as an immunosuppresant •Sirolimus also known as rapamycin which are produced by the bacterium streptomyces hygroscopicus; serves as an immunosuppresant Over 1 million angioplasty procedures performed in U.S. per year and approximately 454,000 stent implants (45% of procedures) per year.
  • 5. The evolution of interventional cardiology and related balloon angioplasty and coronary stent placement has greatly benefited patients, however interventional cardiologists still seek “the perfect stent”. Near-Future: Bio-Compatible stents will mark the 5th Revolution in cardiology as it will herald a new era given its untethered, and hence extremely versatile function and also offers the precision of robotic- assisted surgery (RAS).
  • 6. The Solution: Artery Repair Apparatus or biocompatible-stent, fabricated from bio-compatible (assembled from nano-scale elements), semiconductor elements, will be the 5th Revolution in cardiovascular care, treating complex occlusions and vessel aneurysms in a way that was not clinically possible before. “Sub-12-French devices negating the need for a surgical cutdown (i.e. when the vein is exposed surgically) could be marketed and sold to a wider customer base.” •Control guidance of the stents is enabled by the use of Nuclear Magnetic Imaging technology- ability to reach capillaries in the brain & lower extremities •This invention has several advantages over prior angioplasty and stenting technologies, such as being untethered, 100% image guided, and benefits from the precision of Robotic Assisted Surgery (RAS), which is fully integrated into it. •Will place endovascular grafts within the human body to the effect of facilitating rapid delivery (critical in the case of Thoracic Aortic Aneurysms (TAA) and Abdominal Aortic Aneurysms (AAA)) of a fused stent (patch). •The stent will be manufactured from bio-compatible semiconductor cells, which will be used to repair weakened human vessels such as arteries and veins. •By repairing and supporting weakened artery walls, aneurysms and their clinical manifestations can be prevented. •Upon assembly of the stent, this innovative process will detect, control, position, and fuse the stent(s) by means of Nuclear Magnetic Imaging.
  • 7. Stent Device (AARA) Endovascular Grafting Stent Fabricated by Apparatus & Procedure Cells - Customize Sizes & Shapes Implanted Stent – Nuclear Magnetic Cells Manufactured Resonance (NMR) from Bio-Compatible Technology Controls Semiconductor Cells Movement of the Stent Present Methods Reinforce Weakened or Require Expert Abnormally Dilated Vessels Surgeons
  • 8. Stent Device (AARA) • Repair weakened arteries, vein walls, or other human body vessels • Reinforce artery and vein walls • Utilizes resilient flexible substance inert to bodily fluids • Stents are adjustable & expandable • Based on the radio frequency (RF) • Can be made smaller or larger (in order to accommodate vessel size and structure, allowing for ideal placement and implantation) • Controlled by magnetic properties, which is very precise
  • 9. The Automated Artery Repair Apparatus (AARA) has several advantages over existing stent and vascular graft technologies. It will be a game-changer, as its robotic assisted surgery capabilities are analogous to the automobile revolution of driverless cars. “Advances in robotic surgery and hybrid endovascular and open surgery techniques will open new frontiers for surgeons.” Clinical Challenge Angioplasty-Placed Stents Automated Artery Repair Apparatus (AARA) Angioplasty fails to adequately open an artery Stent must be put in-place by the guidewire, but determining the right-size French catheter takes time (trial & error). Since the AARA is deployed directly into the blood-stream and does not require wire determination, the stent can be quickly and efficiently deployed to the effected site Traditional stents are susceptible to stent thrombosis and in-stent restenosis (ISR); there is a 5% incidence of ISR with drug-eluting stents and 20-30% with bare-metal stents. ISR is associated with significant morbidity. Drug-eluting stents are marketed to reduce the thrombosis risk, but risk of in-stent restenosis persists. The compound materials which AARA will be constructed from will resist thrombus formation; in-stent restenosis of the biocompatible stents is very unlikely given its nanoscale. Endothelial (artery wall) Damage and smooth muscle cell necrosis (death of cells) and neo-intimal hyperplasia Today’s stents have better recoil, allowing for better placement and image-guided placement (OCT, IVUS, MRI), however it is not done routinely; only in a minority of procedures. AARA placement will be very precise by the employment of Robotic Assisted Surgery (RAS) and MRI image-guidance will be used 100% of the time as it is integrated into the system. Placement of stents into diabetic patient presents certain obstacles and complex decisions Patients with Diabetes Mellitus may have to comply with a dual-anti-platelet therapy (DAPT) and have higher rates of ISR. The AARA will be developed to address the diabetic patient; the risk of ISR is negligible. Difficult-to-stent anatomical areas such as bifurcations Placement of BMSs and DESs are difficult in tortuous arteries and bifurcations as a cardiologist must navigate these with the guidewire AARA will have no difficulty in reaching the thinnest arteries and will be able to circumnavigate any vessel or bifurcation given its nanoscale size and MRI-guidance. Stent Obstructions Permanent Metallic Stents can cover side branches and cause overhang at ostial lesions and inability to graft the stented segment. Again, given AARA’s nanoscale size, it will not cover side branches or overhang.
  • 10. Continued: Advantages of the Artery Repair System over traditional, catheter-deployed stent systems. Clinical Challenge Angioplasty-Placed Stents Automated Artery Repair Apparatus (AARA) Coronary imaging requires high temporal resolution to resolve the constant motion of the respiratory and cardiac cycles (i.e. diastole/systole) and high spatial resolution for the accurate imaging of very small vessels. Angiography, the standard imaging in an angioplasty and stent placement procedure, has limited capabilities and newer modalities (Intravascular Ultrasound (IVUS), Computed Tomography (CT), and Magnetic Resonance Imaging (MRI) are not routinely used. AARA will ALWAYS employ the use of image-guided (MRI) stent-placement as it is integrated into the system and works seamlessly with robotic-assisted surgery functionality. Biomechanical Factors: Persistent non-physiological stresses inside the arterial wall or abnormal wall shear stresses (WSS) caused by a stent- disturbed hemodynamics that undermine the correct endothelial functionality. Traditional stents are prone to these structural and hemodynamic problems. AARA, will cause negligible wall shear stress or any changes in vessel hemodynamics, due to its nanoscale size. The most important geometric characteristics for a stent are: Length, Diameter, Strut Thickness, and Mesh Shape Thinner stent struts, compounds (i.e. cobalt chromium, platinum chromium) allow for improved geometric properties, however they are still limited by their manufacturer’s factory design, which is static. The biocompatible stents have almost limitless ability to conform to the needs of the obstruction and corresponding vessel; it is incredibly versatile and adaptable. It can conform to each unique situation and form accordingly. Deeper attention is being paid to complex geometries such as curved vessels or coronary bifurcations, in terms of stenting these difficult areas Thinner-strutted stents, bioresorbable coronary scaffolds, and image-guidance address this challenge, but there are physical limits to what traditional stents can accomplish. AARA is the perfect solution to stent placement in these difficult anatomical areas of vessels as both their nanoscale size, and precise navigation can effectively stent all of these areas. Sub-optimal stent deployment leads to late adverse events Until advanced image guidance is utilized routinely with catheter-based stent placement, optimal stent placement is unlikely when it is not. Adverse events when utilizing AARA will be significantly reduced due to precise and effective stent placement.
  • 11. Why does the Automated Artery Repair Apparatus employ Robotic Assisted Surgery (RAS)? What are its advantages over laparoscopic or traditional surgery? • The system integrates RAS into its platform because it is more precise, more efficient and faster to deploy the stent or conduct the artery repair. This technology utilizes very fast computer processors & related computer software to guide and control the biocompatible stents or devices. The previous generation of catheters and stents require skilled surgeons to manually guide & control the devices. With this new system, the surgeon still directs the surgery, however computer mapping and algorithms offers optimal navigation routes and placement locations. This represents a huge leap in technological innovation. ADVANTAGES OF ROBOTIC ASSISTED SURGERY (RAS): • Minimally invasive • Greater visualization • Precision of the internal surgical work • Augments the skills of a surgeon • Enhanced dexterity: extremely fine & precise movements by the biocompatible stents and their active functions • Physician looks at the console versus the patient • More effective surgery equates, clinically, to easier and shorter recovery period, with fewer complications • With the aid of computer intelligence, the visualization of a procedure and the support for surgical movements is becoming more precise. • Less pain & blood-loss for the patient • Quicker patient recovery and related shorter hospital length-of-stay (LOS) • Integrated Surgery: integrate anatomic data (MRI, CT, US); this means better guidance
  • 12. Worldwide Stent Market Size: Coronary & Vascular Stents: World demand for stents to treat atherosclerosis is growing, especially in emerging markets (i.e. India, China, South America) due to a rising prevalence of cardiovascular disease, an aging population, and further penetration in emerging markets. • The global interventional cardiology and peripheral vascular devices market is expected to reach $26.72 Billion by 2019 from $18.73 Billion in 2014, at a CAGR of 7.4% from 2014 to 2019. • U.S. market for coronary stents is forecast to be $5.61 billion by 2020 (BMS/DES) • Key Emerging Market Sales of coronary stents are $2.3 Billion with projected 7% annual growth • Global stent sales are forecast to grow at nearly double-digit rates between through 2021 • 59.6% of stent market is comprised of coronary stent sales Coronary Stents
  • 13. The Worldwide market share for coronary stents is concentrated between Abbott Laboratories, Boston Scientific, and Medtronic, however some new entrants with cutting-edge solutions are entering the fray and are pushing the boundaries in stent technology and making breakthrough Innovations. These innovations include hybrid (drug-eluting and biodegradable) stents, bioresorbable coronary scaffolds, and proprietary anti- platelet drugs, such as Biosensor’s Biolimus A9. Note: Others include: Microport Scientific (China)- www.microport.com, Biotronik, Inc. (Germany)- www.biotronik.com, Sahajanand Medical Technologies (India)-www.smtpl.com, Elixir Medical Corp. (U.S.)- www.elixirmedical.com, and Stentys S.A. (France)- www.stentys.com Worldwide Coronary Stent Sales by Manufacturer In Millions of US$   Abbott Laboratories (U.S.)- www.abbott.com Boston Scientific (U.S.)- www.bostonscientific.com Medtronic Corp. (U.S.)- www.medtronic.com Terumo Medical (Japan)- www.terumomedical.com Biosensors (Japan & Singapore)- www.biosensors.com Others 2013 Sales                                     1,375                                            815                                   1,780                                         346                                 336           784  2014 Sales                                     1,463                                            865                                   1,740                                         367                                 324           933  % Change 6.0% 5.8% -2.3% 5.7% -3.7% 16.0% Total Worldwide Market Value (2014) 5,692
  • 14. As stent technology has evolved, entrenched players as well as new entrants have developed a wide-range of stent product systems. Drug-eluting stents (DES) are now the “gold-standard” of care, however a market still exists for bare-metal stents (BMS). Along with BMS and DES, both entrenched and new players are marketing a plethora of innovative and very clinically advanced stent solutions. Coronary Stent Products by Manufacturer   Abbott Laboratories Boston Scientific Medtronic Corp. Terumo Medical Biosensors Microport Scientific Biotronik Inc. Sahajanand Medical Technologies Elixir Medical Corp. Stentys S.A. Bare Metal Stents (BMS) Promus Premier Rebel (PtCr alloy),  VeriFLEX Integrity BMS     Tango, Mustang, Waltz   Flexinnium,  Tetriniun (Cobalt  Chromium Stent)   Self-opposing  BMS- currently  in FDA study Drug-Eluting Stents (DES)- Everolimus, Sirolimus, Rapamycin Xience Alpine Promus Element,  Promus Premier  (Platinum  Chromium) Resolute Integrity-  1st and only FDA  approved DES for  Diabetes Ultimaster  (Sirolimus)   Firehawk (Rapamycin)- World's 1st & only target  eluting stent (TES),  lowest drug-dosage   Supraflex,  Vactaflex,  Indolimus  (Sirolimus) DESyne    Drug-Eluting Stents (DES)- Paclitaxel   ION                 Biodegradable Polymer Stents   Synergy     S-Stent     EveroFlex  (Everolimus) DESyne BD-  achieves bare- metal surface  in 6-9 mos.   Coronary Grafts GraftMaster RX                   Polymer Bioresorbable Vascular Scaffold (BVS) Absorb BVS     ART   Firesorb Bioresorbable  Target Eluting Coronary  Scaffold System  (Rapamycin)- First-in- Man DREAMS  (magnesium  alloy)   DESolve BRS  
  • 15. • Vascular stents are required and implanted for the same reason that coronary stents are, that is to support an artery like a scaffold, once balloon angioplasty has been performed; the clinical indication is usually atherosclerotic plaque obstructing the artery. Also, just as drug-eluting coronary stents are deployed, to reduce endothelial damage and speed-up recover, vascular drug-eluting stents are now available. • Vascular artery occlusions can have serious implications for a patient including limb malfunction and poor limb vascularization, which can possibly lead to limb amputation, it can cause the patient severe pain and difficulty or inability to walk, and it can also effect one’s venous return or blood-flow, negatively impacting their heart’s filling (diastolic function). • Vascular stents are placed and implanted just as coronary stents are, with vascular angioplasty guidewires and balloons, however specified for certain vascular areas; this can include carotid, iliac, and femoral (above-the-knee (suprapopliteal) or below-the-knee (infrapopliteal). There are also vascular stents for biliaries, bronchial, renal, and urinary vessels. • Vascular grafts are usually needed when a major vascular artery, such as the thoracic aorta (TA), abdominal aorta (AA) shows evidence of an aneurysm (detected by X-ray, ultrasound (US), computed tomography (CT), or magnetic resonance imaging (MRI). The risk of a thoracic (TAA) or abdominal aortic aneurysm (AAA) rupturing can be death (AAAs are one of the top 10 causes of death for Men in the U.S.). • Vascular grafts are placed surgically and serve to support the artery, also like a scaffold, but cover a larger anatomical area than stents, since these arteries are relatively large (around 3.0 – 4.0 CM in diameter). These grafts are then visible in future medical imaging tests. What clinical situations necessitate implantation of a vascular stent or endovascular graft? How are vascular stents guided & implanted?
  • 16. The worldwide Endovascular Graft Devices market is experiencing very healthy growth as more interventional options are available to patients with this potentially life- threatening condition. Also, the occurrence of aortic aneurysms is increasing worldwide. • The Worldwide Aortic Stent Grafts Market will be worth $1.9 Billion by 2020 while growing at a CAGR of 9.5% to 2018 and 6.7% to 2020. • The U.S. EVAR endograft market, which represents over 50% of the worldwide market, is currently valued at about $760 million with a CAGR of 8% per year.
  • 17. The worldwide vascular stent & endovascular grafting market is experiencing faster growth (around 7-8% annually) as compared with the coronary stent market (4-5% annually). This brisk growth is being driven by greater awareness and detection of vascular disease and its implications, new medical technology to address it (such as below-the-knee angioplasty & stents), and more disposable income to pay for these treatments. Worldwide Vascular Angioplasty, Stent & Endovascular Graft Sales by Manufacturer In Millions of US$   Abbott Laboratories (U.S.)- www.abbott.com Boston Scientific (U.S.)- www.bostonscientific.com Medtronic Corp. (U.S.)- www.medtronic.com C.R. Bard, Inc. (U.S.)- www.crbard.com Others 2013 Sales                                469                                             809                                    867                                    830                                    370  2014 Sales                                527                                             850                                    895                                    928                                    407  % Change 6.0% 4.8% 3.1% 10.6% 9.2% Total Worldwide Market Value (2014) 3,608 Note: Others include: Terumo Medical (Japan)-www.terumomedical.com, Microport Scientific (China)- www.microport.com, and W.L. Gore & Associates (U.S.)-www.gore.com
  • 18. The lion’s share of the vascular stent market is concentrated amongst the same major players in the coronary stent market, however Boston Scientific, Medtronic, and Microport Scientific market the most diverse and comprehensive product lines of vascular stent & endovascular grafting solutions. Additionally vascular stent solutions evolve with drug-eluting vascular stents, more versatile vascular angioplasty and stent placement, as well as endovascular grafts for aortic bifurcations. Vascular Stent & Endovascular Graft Products by Manufacturer   Abbott Laboratories Boston Scientific Medtronic Corp. Terumo Medical Biosensors Microport Scientific Biotronik Inc. Vascular Stent - Carotid RX Acculink- 1st-to- market for carotid  stents WALLSTENT- Monorail  Endoprosthesis           Vascular Stent- Iliac Omnilink Elite-  expandable stent  system EPIC-self-expanding  stent system           Vascular Stent- Femoral Arteries   Innova-self- expanding stent  system   Misago RX-self-expanding  peripheral stent (for  superficial femoral artery &  proximal popliteal artery) Biomatrix Flex- Infrapopliteal   Astron-Lower-limb  arteries (Femoropopliteal  & Infrapopliteal), Astron  Pulsar - Gold-plated,  Pulsar-35 (Suprafemoral) Endovascular Grafts (AAAs & TAAs) Absolute Pro- self- expanding stent  system WALLSTENT- Endoprosthesis Endurant II-AAA,  Valiant-TAA, Talent- TAA      Hercules T- Transthoracic,  Hercules B- Bifurcated Graft  System, Aegis  Bifurcated Stent  Graft System    Vascular Drug- Eluting Stents         Biomatrix Flex- Infrapopliteal  (Biolimus A9- proprietary)    
  • 19. • While stent technology has become very effective for treating patients suffering from cardiovascular disease, and even raising the bar in terms of outcomes, many clinical challenges persist. These include speed-to-repair, complex lesions, treating complete coronary blockages, and making image-guided stent placement routine, which today IT IS NOT; one of the keys to long-term stent treatment success. Summary: Why Zurn’s AARA or Biocompatible Stent is Much Better! • Precise stent deployment: Robotic Assisted Surgery is fully-integrated into the AARA. • Limitless anatomical placement of Bio-compatible stents: Stenting will be possible & effective in the most difficult anatomical areas such as small brain capillaries, below-the-knee (infrapopliteal) arteries, tortuous vessels, and vessel bifurcations; this will provide new treatment options for patients suffering from stroke-related diseases and limb ischemia, both of which can be life-threatening. • Faster Time-to-Treatment (“Time is Brain”): The AARA can be deployed more quickly than wire-catheter-based stent systems, since they are directly injected into the blood-stream and navigated to the lesion immediately; their untethered characteristic negates the need to scale a guidewire to a French Catheter, which can delay stent deployment and care. • Faster Patient Recovery & Healthcare Cost Savings: Better stent placement offered by AARA means significantly reduced adverse effects (lower risk of thrombus formation, less endothelial damage), and hence a shorter hospital length-of-stay (LOS) for the patient. The Artery Repair Apparatus is a Superior Solution over existing stent technologies. It will come to be known as a disruptive clinical solution, as it takes a REVOLUTIONARY approach to vessel support and repair. Namely, the integration of Robotic Assisted Surgery (RAS) and its many accompanying advantages & benefits.
  • 20. Professional Background: Clifford M. Thornton, Marketing & Executive Support • Highly competent and experienced in Cardiac Diagnostics (specialized in echocardiography / cardiac sonography) and related knowledge on heart diseases (including cardiomyopathies) • Certified Cardiovascular Technologist, Sanford-Brown Institute, 2004 • Registered Diagnostic Cardiac Sonographer (RDCS) – American Registry of Diagnostic Medical Sonographers (ARDMS) – Retired status (was actively scanning from 2006 – 2014) • Performed approximately 5,000 adult transthoracic echocardiograms (TTE) and 2,000 adult transesophageal echocardiograms (TEE) (with performing cardiologist). Quality of studies rated by reading cardiologists most often in the good to excellent range. • Developed strong and fluid working relationships with interventional and non-interventional cardiologists such as Michael S. Flynn, M.D., FACC (was listed in Castle Connolly’s America’s Top Doctors – 2012-2013) and Julian Javier, M.D., Co-founder of Vascular Device Partners (conducts first-in-Man medical device investigative studies). • Successfully served as an echocardiography teacher & instructor for 4 years at a healthcare training school, helping students pass their echo board exams and receiving very positive feedback from students. • Worked independently and successfully as a contract echocardiographer for private cardiology practices, internist clinics, and mobile ultrasound firms (in New Jersey, New York, Florida, Maryland, North Carolina, and Hawaii). • Prior to entering the cardiac diagnostics field, acquired Fortune 500 experience as a Program Manager and Business Analyst • As a Program Manager for Lucent Technologies and then Avaya (was employed by them during the Avaya spin-off), served as an integral member of the core teams for the product launches of mid-sized business communications systems, Merlin Magix R2.0 and IP Office R1.0. • Served as a Business Analyst in MediaOne Group’s Market Strategy Development (MSD) Team, supporting directors on high-level business plans for high-speed internet over coaxial cable, video-on-demand (VOD), and a FCC auction for Local Multi-Point Distribution (LMDS) service or microwave-based wireless broadband communications. MediaOne Group evolved from USWest Media Group and has since been acquired by Comcast Corporation. • Served honorably in the United States Navy Reserve from 2002 – 2010 (in IRR from 2007 – 2010). Voted Sailor of Quarter (April – June, 2004) for unit CART B-104, NWS Earle, Colts Neck, NJ • Other academic credentials: B.S. Business Administration, Major: Marketing, New York University, Leonard N. Stern School of Business, 1997, Made Dean’s List in 1996 (under Dean Frederick Choi)
  • 21. Sources utilized for this presentation • “Modeling Drug Release in Cardiovascular Eluting Stents”, Grassi G., Grassi M., Pontrelli G., Teresi L. in: Modelling Cardiovascular System and Mechanical Circulatory Support, Claudio De Lazzari Ed., CNR, pp. 135-151, 2007 • University of Michigan Health System – Coronary, http://www.med.umich.edu/cardiac- surgery/patient/adult/adultcandt/coronary_angioplasty.shtml • Medscape: Peripheral Vascular Stent Insertion, Author: Dale K Mueller, MD; Chief Editor: Karlheinz Peter, MD, PhD, http://emedicine.medscape.com/article/1839716-overview • “What is robotic surgery with the da Vinci Surgery system?”, http://www.laparoscopic.md/robotic • University of Cincinnati Health, http://uchealth.com/services/robotic-surgery/patient- information/benefits/ • Mayo Clinic, “Robotic Surgery”, http://www.mayoclinic.org/tests-procedures/robotic- surgery/basics/definition/prc-20013988 • Aortic Stent Grafts – Global Analysis and Market Forecasts, MediPoint, http://www.reportsnreports.com/reports/300725-medipoint-aortic-stent-grafts-global- analysis-and-market-forecasts.html • “EVAR Update: Competitors Stake Their Ground In a High-Growth Space”, Mary Thompson, MedTech Insights, April 2013, http://www.nea.com/uploads/files/employee/TriVascular.pdf • “Endovascular Repair of Aortic Disease: A Venture Capital Perspective”, Seminars in Interventional Radiology, 2009 Mar; 26(1): 56–66., http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036456/ • Interventional Cardiology & Peripheral Vascular Devices Market (Embolic Protection, Chronic Total Occlusion, Atherectomy, Thrombectomy, IVUS, Angiography Catheters, EVAR Stent Grafts, IVC Filters, Stents, Balloons and Accessories) - Forecasts to 2019”, MarketsandMarkets • “REBEL Bare Metal Stent Could Be A $200 Million Opportunity For Boston Scientific”, Forbes, March 21, 2014
  • 22. Sources utilized for this presentation (Continued) • CORONARY STENTS – GLOBAL ANALYSIS AND MARKET FORECASTS, GlobalData – MediPoint, November 2014 • “Coronary stents: historical development, current status and future directions”, Oxford Journals, February 2013 • MediPoint: Coronary Stents - US Analysis and Market Forecasts, November 2014 • “Coronary Stents and Noncardiac Surgery: Current Clinical Challenges and Conundrums”, http://onlinelibrary.wiley.com/doi/10.1111/j.1751-7141.2009.00044.x/full • “Modeling Stented Coronary Arteries: Where We are, Where to Go”, Annals of Biomedical Engineering, July 2013, Volume 41, Issue 7, pp 1428-1444, http://link.springer.com/article/10.1007/s10439-012-0681-6 • “Novel design of drug delivery in stented arteries: a numerical comparative study”, Math Biosci Eng. 2009 Jul;6(3):493-508, http://www.ncbi.nlm.nih.gov/pubmed/19566122 • “Below-the-knee Interventions”, Cardiovascular Intervental Radioly, 2013, 36:302–311, http://www.cirse.org/files/files/SOP/2013/SoP_BTK%20Interventions_vanOverhagen_2013.pdf • Abbott Laboratories, www.abbott.com, 2014 Annual Report • Boston Scientific, www.bostonscientific.com, 2014 Annual Report • Medtronic Corporation, www.Medtronic.com, 2014 Annual Report • Terumo Medical, www.terumomedical.com, 2014 Annual Report • “Elixir Medical’s Contrarian Play in Cardiology: Go Bioresorbable or Go Home”, The MedTech Strategist, June 30, 2015, Vol. 2, No. 12