9. Chymotrypsin is a serine protease enzyme that continues to vee subs, but many non- physiological substrates activity relationships. The physiological substrates are proteins, but mante is ethyl N-acetyl-L-tyrosinate (structure are used Inhibition studies were conducted with the two competitive inhibitors, benzeneboronic acid and benzylalcohol, and the K1 values determined. [ M. Philipp and M. L. Bender, (1971) Proc. of the Natl. Acad. of Sci. 68pp478480.] a. Which inhibitor binds with the greatest affinity? b. Propose an explanation for the difference in affinity based on the structure and shape of the two inhibitors. bentene boronic acid looks mor e is shown. The amino acids Gly 193, Ser 195 . His 57 Polar. and Asp 102 form part of the active site. A portion of a natural peptide substrate from R to R is depicted with the residue phenylalanine occupying the hydrophobic pocket of the enzyme..