5. Mechanism of Action
SURVIVAL
• DNA replication
• Transcription
• Repair
• Recombination
Bacteria
• Bacteria utilize the 4 mechanisms (above) to survive
• Ciprofloxacin inhibits these 4 mechanisms
• Inhibition of these mechanisms kills the bacteria
Accessed: http://www.rxlist.com/cipro-drug.htm
6. Indication and Use
• urinary tract infections
• acute uncomplicated cystitis
• chronic bacterial prostatitis
• Lower respiratory tract infections
• Acute sinusitis
• skin and skin structure infections
• bone and joint infections
• complicated intra-abdominal infections
(used in combination with
metronidazole)
• infectious diarrhea
• typhoid fever (enteric fever)
• uncomplicated cervical and urethral
gonorrhea
• inhalational anthrax (post-exposure)
Accessed: http://www.rxlist.com/cipro-drug.htm
8. What is Rhinitis?
• Inflammation of the nasal mucosa
• Can be triggered by bacteria, virus,
or allergens
• Mast cells are central to the
pathophysiology of rhinitis
• Release of histamine by mast cells
trigger the symptoms associated
with the disease (itching, runny nose,
sneezing, etc)
• Eosinophils and Basophils have also
been showed to be involved
Accessed: http://en.wikipedia.org/wiki/Rhinitis
9. Mechanism of Action
Mast cell BasophilEosinophil
• These 3 cells types have a role in rhinitis
• Fluticasone proprionate inhibit activity in
these cell types
• The result is anti-inflammation
Accessed: http://www.rxlist.com/flonase-drug/clinical-pharmacology.htm
10. Indication and Use
• Nasal Spray is indicated for the management of the nasal symptoms of
seasonal and perennial allergic and nonallergic rhinitis in adults and
pediatric patients 4 years of age and older.
Accessed: http://www.rxlist.com/flonase-drug/clinical-pharmacology.htm
12. Mechanism of Action
Mast cell
• When body encounters allergen, mast cells
are activated
• Histamine granules are released
• Histamine can act on blood vessels and
nerves to induce erythema and itching,
respectively
• Elicits “allergy symptoms”
Accessed: http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=8262
Allergy symptoms
13. Mechanism of Action
Accessed: http://www.optometricmanagement.com/content/archive/2008/may/images/om_may_a16_fig04.jpg
• Anti-histamines bind to
the histamine receptors
• Blocks the histamine from
binding to the receptor
• Reduces the symptoms
associated with allergy
14. Indication and Use
• Seasonal Allergic Rhinitis
ALLEGRA (fexofenadine hcl) is indicated for the relief of symptoms
associated with seasonal allergic rhinitis in adults and children 2 years
of age and older.
• Chronic Idiopathic Urticaria
ALLEGRA (fexofenadine hcl) is indicated for treatment of
uncomplicated skin manifestations of chronic idiopathic urticaria in
adults and children 6 months of age and older.
Accessed: http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=8262
