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BPLab: booklet
1. *since 1997*since 1997*since 1997
A VARIETY OF SOLUTIONS
in one system
BPLab® ABP monitors* & Vasotens® technology
2. Die Methode ist alles.
Carl Ludwig
BPLab® ABP monitors* & Vasotens® technology
Discover the method, which possibilities are so promising, that every practical cardiologist and researcher
could dream about. We are talking about modern automatic sphygmomanometers. The systems BPLab®
manufactured since 1997 are perfectly stable in this method. Originally developed for 24-hour blood pressure
assessment (ABPM), oscillometric recorders provide data of single-channel volume sphygmography at the
brachial artery – as a result, the system has become the first 24-hour pulse wave analisys (PWA) device in
the world. Today, in addition, BPLab® devices are widely used for in-office measurements in patient stream
and they have become compatible with telemedicine systems. Moreover, they perfectly meet the require-
ments both of smaller-scale studies and of multi-center clinical trials.
This is proved by a number of factors: conformity of production with ISO-requirements, measurement preci-
sion of the developed equipment. The following chart illustrates validation results of BPLab® and BPLab-Va-
sotens® systems.
The systems cannot be functionally depreciated because volume sphygmograms obtained during the cuff
deflation are stored in the memory of a device and are available for post-processing on the PC. While medi-
cal societies are gaining experience in hypertension management, the method of data processing is being
improved as well – what multiple users of BPLab-Vasotens®-systems might have already appreciated.
Indices Population Result
SYS/DIA BP (BHS-93 protocol) General Class A/A*
SYS/DIA BP (BHS-93 protocol) Children Class A/A*
SYS/DIA BP (BHS-93 protocol) Pregnant Class A/A*
Central BP General pass*
Pulse Wave Velocity General pass*
Augmentation Index General pass*
* see for reference http://bplab.com/articles.php
It’s no surprise that the present equipment is recommended by such well-respected organizations as
www.bhsoc.org and www.dableducational.org. However, a cardiologist and researcher assesses not only
systolic (SYS), diastolic (DIA), mean (MBP) or pulse (PP) pressure, but also a number of additional very
relevant parameters such as central aortic pressure (CAP [ SYSao, DIAao, MBPao]), brachial and aortic aug-
mentation index (AIx), ejection duration (ED), pulse pressure amplification (PPA), pulse wave velocity (PWV),
reflected wave transit time (RWTT), maximum rate of blood pressure rise (dP/dtmax), subendocardial viability
ratio (SEVR) and even as a set of options, ankle-brachial index (ABI) and information on a patient’s activity
and body position.
*see www.bplab.com
3. OFFICEMEASUREMENTS
Automated in-office measurements with
the use of BPLab®-Vasotens® systems
are convenient for preliminary stratifica-
tion of cardiovascular risk in patients with
arterial hypertension (Vasotens® Office
Stiffness) or other cardiovascular patholo-
gies (Vasotens® Office ABI); moreover
the system can detect spurious systolic
hypertension in youth, evaluate drug
therapy effect mainly affecting CAP (Va-
sotens® Office CAP).
To perform measurements, BPLab®
device and PC with Vasotens®Office
software are required. During patients’
visits the BPLab® device is continuously
connected to the computer – so you can
manage process of measurement of SYS
BP, DIA BP, AIx, AIxao, central BP and
PWV via PC.
Anyone, who completed training in arterial
blood pressure measurement, should
understand how it is important to estab-
lish a good cooperation with a patient and
select an appropriate cuff size in order to
carry out the test very carefully.
Please run Vasotens®Office application
and start a new test, follow the user-
friendly algorithm, analyze the data
records, control their quality, detect pulse
wave features of your patient, print out
measurement reports or save them as
PDF-files.
Don’t forget that you can still use the
BPLab® monitor which is a part of BPLab-
Vasotens® system as a regular 24-hour
ABPM as well.
How it works
in a nutshell
BPLab® ABP monitors* & Vasotens® technology
*see www.bplab.com
4. Die Methode ist alles.
Carl Ludwig
BPLab® ABP monitors* & Vasotens® technology
Speaking of the method of registration, it is worth mentioning the principle of storage of volume
sphygmograms in BPW-files. This principle provides essential advantages for general practition-
ers and researchers who use BPLab-Vasotens® systems.
For example, scrupulous researchers can use both an automatic analysis of measurement qual-
ity control of 24-hour ABPM tests and a visual inspection of all recorded curves. The next figure
demonstrates a normal waveform and a waveform with a movement artefact.
BPLab-Vasotens® equipment is a unique diagnostic system which combines traditional 24-hour
blood pressure measurement with 24-hour central aortic pressure and 24-hour arterial stiffness
analysis.
The device shows high validity of the obtained results according to a number of per-day meas-
urements. This number is equal both for peripheral blood pressure and central aortic pressure
in all patients. It is related to the fact that pulse waves for ambulatory analysis are recorded the
same way as peripheral blood pressure data – with no additional inflation step. On the other
hand, all BPLab-users can easily upgrade a regular 24-hour ABPM to the improved PWA-system
or reanalyze the available BPW-files for additional parameters.
The rapid progress of telecommunication platforms has affected the development of BPLab-Va-
sotens® systems as well. It is easy to understand that the centralized assessment of BPW-files
has become very attractive for telemedicine business. Indeed, the whole medical community is
invited to support the web-based service: www.tholomeus.net which is widely using BPLab® and
BPLab-Vasotens® systems with remote computed arterial stiffness and central aortic pressure
assessment, without necessity to install local software copy on your computer.
User-friendly software interface of BPLab-Vasotens® systems enables configuration of medical
reports according to a doctor’s requirements: this could be graphs of blood pressure and other
indices, the full table of results, histograms, cosinor analysis, morning trends, arterial stiffness
and central aortic pressure analysis and many more.
*see www.bplab.com
5. AMBULATORYMONITORING
24-hour ABPM BPLab® device, PC, and,
optionally, an activity and body position
sensor are required for ambulatory monitor-
ing. BPLab® Standard monitor is initialized
via BPLabWin® software on the computer or
telemedicine system web-application.
Feel free to upload an individual plan of
measurements, but do not forget to provide
a sufficient number of good-quality measure-
ments according to the current guidelines. If
you are interested in chronobiology, you may
upload a device for a test within 48 hours or
longer.
In any case, upon a test completion, you
need to connect the monitor to a PC and
transfer the measurement results from de-
vice memory into computer or upload them
into telemedicine system.
To interpret test results, please download
the current BPW-file to your PC and launch
BPLabWin® software for standard 24-hour
blood pressure procedure and Vasotens®24
(including dongle key and registration data)
for 24-h PWA. Another opportunity is to
use the telemedicine platform and/or cloud-
based service Saas Vasotens® for subse-
quent data processing and analysis. Upon
completion please print out the report or
generate a PDF-file.
How it works
in a nutshell
BPLab® ABP monitors* & Vasotens® technology
*see www.bplab.com
6. Die Methode ist alles.
Carl Ludwig
BPLab® ABP monitors* & Vasotens® technology
Due to recording of sphygmograms which can undergo postprocessing, the system is very
flexible and can be configured for different purposes – even for complicated multi-center
clinical trials of drugs. Equipment BPLab-Vasotens® is currently successfully used in different
clinical centers in more than 25 countries. The following chart explains the delivery procedure
of equipment for a multi-center study, testing, for example, the drug impact on 24-hour CAP
profile. Cost effectiveness is achieved by a provision of standard 24-hour ABPMs to research
centers; at that time data management center is supplied with the required software BPStat®
which enables processing of a great number of BPW-files (raw data) for additional parameters
as well.
Delivery sets Trial centre Data management
unit
Hardware: BPLab® Standard
(24-hour ABPM, USB-cable, cuffs,
operating manual, CD, meter,
bag, two belts)
+ -
Software: BPLabWin® + +
Vasotens® 24 - +
BPStat® - +
Dongle key + registration data - +
Furthermore, research projects can be supported by manufacturer of BPLab-Vasotens® sys-
tems in a different way. The privileged conditions for the use of systems can be provided upon
submission of a research synopsis. As may be agreed, the manufacturing company staff can
hold a presentation of the equipment during first investigators’ meetings, conduct training of
the principle researchers and data managers.
Storage of oscillograms can offer another advantage – speaking of academic studies: once
you’ve collected the measurement files you should be aware that the available bulk data can
be reanalyzed after software update for some new parameters – a researcher gets an oppor-
tunity to conduct a retrospective study based on previously recruited groups of patients and
immediately obtain data which might have certain scientific novelty.
*see www.bplab.com
7. MULTICENTERRESEARCH
If you need to analyze hundreds or
thousands of BPW-files (raw data),
there is no better solution than
BPStat® software. Complete instal-
lation, double-click the software
shortcut, select the appropriate
BPW-files in your computer, tick
the hemodynamic and vascular
wall parameters which have to be
assessed in the summary table,
and get a report. The report can be
easily exported into the required
software such as MS Excel.
Day-time/night-time average val-
ues or variability of central aortic
pressure, peripheral blood pres-
sure and arterial stiffness etc. can
be assessed via BPStat®-software.
The received data can be present-
ed in a single line for each patient
or as multiple line arrays showing
tracking of BP, CAP, AIx, RWTT,
PWV etc.
This software will be duly ap-
preciated by statisticians who are
engaged in 24-hour analysis of
blood pressure and new param-
eters: anyone from PhD-student in
a small clinic to SAS-developers in
a big research organization.
How it works
in a nutshell
BPLab® ABP monitors* & Vasotens® technology
*see www.bplab.com
8. Main office
OOO Petr Telegin;
37, Gagarin Avenue, GSP 1081, Nizhny
Novgorod, Russia, 603950
Tel: +7 831 2961414
Fax: +7 831 2961415
E-mail: impex@bplab.com,
E-mail: export@bplab.com
www.bplab.com
BPLab in Europe
BPLab GmbH
Berliner Str. 95
65824 Schwalbach am Taunus
Hessen Germany
Tel: +49 17433 357943
E-mail: BPLab.de@gmail.com
E-mail: office@bplab.de
Distributor
in Germany
heart tec Medizintechnik GmbH
Köhler Feld 10, Dorsten-Wulfen 46286
Tel: +49 2369 91720
www.heart-tec.de
Distributor in Czech Republic
ZMF Medical, s.r.o. Meziricska 2868
756 61 Roznov pod Radhostem, CZ
Tel: +420 571 648010
E-mail: info@zmfmedical.cz
www.zmfmedical.cz
Distributor in Italy
Technoel S.r.l.
Via Sandro Penna, 164 - 00133, Roma
Tel: +39 06 7235765
Fax: +39 06 7234638
E-mail: tecnoel@tecnoelsrl.com
www.tecnoelsrl.com
Distributor in Lithuania, Latvia
and Estonia
LTD Graina
Durpyno str. 22, LT-36237 Panevezys,
Lithuania
Tel: +370 45 570605
Tel: +370 45 433540
E-mail: d.titovas@graina.lt
www.graina.lt
Distributor in Turkey
ZEmed Tιbbi Sistem ve Cihazlar Limited
Sirketi, Caddesi Kartal Sokak no 15/5, 34752,
Icerenkoy, Istanbul, Turkey
Tel: +90 216 469 42 80
Fax: +90 216 469 42 52
info@zemed.com.tr
www.zemed.com.tr
Distributor in Slovakia
Adamed, S.r.o.,
E.F. Scherera 38, 21 01 Piestany, Slovakia
Tel: +421 0904 925026
Tel: +421 0903 404729
E-mail: adamed@adamed.sk
www.adamed.sk
Distributor in France
Cardiogap Medical
4 rue Guillaume de Bois Nivard
78640 Neauphle-le-Château, France
Tel. : (33) 1 34 89 97 97
Fax: (33) 1 34 89 97 99
Email: info@cardiogap.com
www.cardiogap.com
Distributor in Austria,
Switzerland, Slovenia
SOT Sonotechnik Karl Glantschnig
W.- Rudnigger-Strabe 18t
9161 Maria Rain Karnten, Austria
Tel: +43 (0) 4227 / 84 991
Fax: +43 (0) 4227 / 84 992
E-mail: office@sonotechnik.at
www.sonotechnik.at
Distributor in UAE
Grand Medical Company
P.O. Box: 35036, UAE. - Abu Dhabi
Tel: +971-2-6777609
Fax: +971-2-6765010
www.grandmed.ae
Distributor in Egypt
MTS (Misr for Trade and Supplies Co.) 6
El Zaher Square, 11271 Cairo, Egypt
Tel: +2 02 27877214
E-mail: support@misrfortrade.com
www.misrfortrade.com
Product Line and Distributors
Basic package BPLab®
Standard BPLab Standard + BPLabWin software for processing of ABPM-
data (SYS, DIA, MBP, PP, HR and Double Product)
BPLab®
Standard A BPLab Standard A with an activity and body position sensor +
BPLabWin software for processing of ABPM-data (the same
parameters)
Cuffs Cuff sizes from pediatric (12-16 cm) to extra-large (38-50 cm)
Additional options
for office measure-
ments
Vasotens®
Office Stiffness In-office (screening) arterial stiffness analysis (PWV, AIx, RWTT,
ASI, dp/dtmax)
Vasotens®
Office CAP In-office (screening) central aortic pressure analysis (SYSao, DIAao,
MBPao, PPA, ED, SEVR)
Vasotens®
ABI Ankle-brachial index (ABI)
Additional options
for ambulatory
minitoring
Vasotens®
24 Stiffness 24-hour arterial stiffness analysis (PWV, AIx, RWTT, ASI, dp/dtmax).
Vasotens®
24 CAP 24-hour central aortic pressure analysis. (SYSao, DIAao, MBPao,
PPA, ED, SEVR).
Additional software BPStat®
Bulk data processing and tabulation
Abbreviations: see page 1