Laboratory anesthetics

1. Laboratory anesthetics
Bestha Chakrapani M.pharm
Department of pharmacology

2. Laboratory anesthetics
Barbiturates are the most commonly used
anesthetics in the laboratory animals.
Pentobarbital sodium (Nembutal) is the
anesthetic of choice.
It produces surgical anesthesia in a dose of 35-
45mg/kg when given by intraperitoneal or
intravenous routes of administration.
The onset of action is almost immediate and
the duration of anesthesia lasts for 45-60 min.

3. AnAesthesiA. AnAesthetising lAborAtory

4. If longer action is needed a maintence dose may be
administered.
It produces reversible anesthesia .
When the drug is given by intravenous route, special
precaution should be taken to administer it slowly
other wise it may cause respiratory paralysis.
Pentobarbitone anesthesia may not be suitable for the
study of cardiovascular drugs as it affects the basal
activity of cardiovascular system.
The other commonly used an aesthetics are
chloralose (80-100mg/kg,ip or iv).
Both these agents produce irreversible and produce
several hours of anesthesia.

5. Since chloralose is not suitable in cold water it
is prepared in boiling water and injected when
hot (30-40 c).⁰

6. AnesthesiA VAporizer

7. RefeRence
Hand book of experimental pharmacology by
S.k .kulkarani.

8. Thank you