Alzheimer

1. ALZHEIMER
BY:
QUROTUL A’YUN,S.KEP.,NS

2. Alois alzheimer
Gangguan
intelektual
dan
memori
1907

3. DEMENSIA??????
ALZHEIMER?????

4. ETIOLOGI
Intoksikasi
logam
Belum
diketahui
Gangguan
fungsi imun
Infeksi virus
Polusi
udara/industri
Trauma
Presdiposisi
herediter
Defisit formasi
sel sel filamen

5. patologik
Degenerasi
neural
patologik
Kematian
daerah
spesifik
jaringan
otak

6. Gejala Klinik

7. Stadium I (1-3 thn) Stadium II (3-10 thn) Stadium III (>12 thn)
Memory New learning &
remote recall more
severely impaired
Recent & remote recal
more severely
impaired
Visuopatial skill Topoghrapic
disorientation, poor
complex contructions
Spatial disorientation,
poor contruction
Language Poor woordist
generation,anomia
Fluent aphasia
calculation Acalculation
Personality Indifference,
occasional irribility
Indifference, irribility
Psychiatry leature Sadness or delution in
some
delution in some
Motor system Normal Restlessnes,pacing Limb rigidity & flexion
poeture
Eeg Normal Diffusely slow Slow baground rhytm
CT/MRI Normal Normal/ventricular &
enlargeen
Ventricular and sulcal
enlargent
PET/SPET Bilateral posterior
hypometabolisme/hyp
erfussion
Bilateral parietal &
frontal
hypometabolisme/hyp
Bilateral parietal &
frontal
hypometabolisme/hyp

8. Pemeriksaan penunjang
CT
scan
MRI
EEG
Lab
darah
SPET

9. Penatalaksanaan
Inhibitor kolinesterase
thiamin
Nootropatik
Klonidin
Haloperidol
ALG

10. DIAGNOSA????