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The Role of Inflammatory Cytokines
in type 2 Diabetes :
Short Review
B I O C H E M I S T R Y
A s h o k K a t t a ,
A s s t . P r o f e s s o r ,
D e p t . o f B i o c h e m i s t r y
2
But..we have
changed from a
primitive hunter-
caveman to a
sophisticated modern
man, especially in the
urban areas
Gains
•Better living conditions
•Variety of foods
•Better transportation
•Better communication
Losses
•More eating
•Less physical activity
•More stress
Obesity
Diabetes
Hypertension &
cardiovascular diseases
Cancer
Leading to….
5
Diabetes
6
Diabetes: A global emergency
7
Diabetes around the world
8
Diabetes around the world
9
10
Diabetes around the world
11
Diabetes around the world
12
Diabetes around the world
13
14
17
18
21
22
Cytokines and Diabetes
23
Cytokines and Diabetes
TNF-α and Diabetes
24
Action of Insuline
25
TNF-α and Diabetes
26Action of TNFα
27
TNF-α and Diabetes
28
IL-6 and TNF alpha
deactivate IRS-2.
30
IL-6 and Diabetes
31
IL-6 and Diabetes
32
IL-6 and Diabetes
33
34
Conclusion
36
37
38

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The Role of Inflammatory Cytokines in Type 2 Diabetes Mellitus : Short Review

Editor's Notes

  1. Intracellular cytokine-associated signaling pathways. JAK, Janus kinase; Tyk, Tirosine kinase; STAT, signal transducer and activator of transcription; MYD88, myeloid differentiation factor-88; IRAK, IL receptor–associated kinase; TRAF, TNF receptor–associated factor; TAK, TGF-β–associated kinase; NIK, NF-κB–inducing kinase; IKK, inhibitor of NF-κB kinase; TRADD, TNF receptor–associated death domain; RIP, receptor interacting protein; MEKK, mitogen-activated protein kinase/Erk kinase kinase; JNK, c-Jun N-terminal kinase.