electro convulsive therapy which is mostly used in psychiatric nursing for providing effective care and treatment to mental ill client in some kind of certain indication of depression,mania and schizophrenia
2. History of ECT
• Von Meduna (1934)- Autopsies of patients
w/ Seizure disorders and of patients w/
Schizophrenia.
• Difference in Glial cell proliferation
5. Cerletti and Bini (1934):
Electricity
Initially done without
muscle blocker or
anesthetic
6. Early ECT
• Assylums
• Few effective medications
• Many often severe side effects
• 1950’s- ether, and curare extract
developed (Abram Bennett- a psychiatrist
helped develop a method for extracting
curare).
• In 1950’s antidepressant and antipsychotic
meds introduced- significantly decreased
7. Electrophysiological
Principles
• Ohm’s Law: I=E/R (I=current, E=voltage,
and R=resistance)
• Dose of electricity in ECT= 100-500
milliCoulombs
• Brain has low impedance (resistance), skull
has very high impedance. Only 20% of
applied charge actually enters the brain.
• Seizure involves propagation of action
potentials in a large percentage of neurons.
8. Mechanism of Action
• Neurotransmitter levels all increased in
CSF after seizure. Results in down
regulation of Beta adrenergic receptors.
• During seizure- PET studies show an
increase in BBB permeability and in
cerebral blood flow and metabolism.
• After seizure, blood flow and metabolism is
decreased especially in the frontal lobes.
Research shows this correlated w/
9. Indications
• Major Depression w/ or w/o psychotic
features
• Bipolar disorder - manic or depressed
phase
• Acute or Catatonic Schizophrenia
• Some studies have shown efficacy in
treating OCD, Delirium, NMS, Chronic
pain syndromes, and intractable seizure
disorders
10. Major Depression
• Efficacy vs antidepressants
• When is it a first line treatment
consideration?
• Length of Antidepressant effect
• Maintenance ECT
11. Bipolar Mania
• Efficacy vs Lithium
• Indications for First Line Treatment:
• -Recent Myocardial Infarction w/ Acute
Mania
• -Pregnancy w/ Acute mania
12. Pre ECT Workup
• Physical Exam
• Head CT
• CXR
• CBC, Basic Chem
• EKG
• ? Spinal Films
14. Treatments
• Premedicate w/ Glycopyrrolate, consider
short acting Beta blocker
• Patient not intubated
• Bite block
• Cuff leg to monitor sz
• EEG and EMG
• Length of sz- 20 sec to 1 min.
15. Number and Spacing of ECT
• 2-3x/wk- efficacy vs less memory
impairment
• 5-12 sessions/ treatment (although up to
20 is possible)
• Point of maximum improvement- no more
improvement after 2 further treatments.
16. Adverse Effects
• Mortality rate: .002% per treatment
session, .01% per patient.
• Sore Muscles
• Head ache
• Short term confusion/ delirium
• Memory
17. Transcranial Magnetic
Stimulation (TMS)
• Rt Frontal lobe- TMS pulses suppress
activity and causes happiness and increased
energy
• Left Frontal lobe- TMS pulses suppress
activity and leads to sadness
• 4/250 had seizure
• 10Hz stimulation 20x/day, 11/17 patients
w/ Major Depression showed significant
improvement.
18. TMS continued
• So far positive effects have not lasted as
long as positive effects from ECT
• Handful of case reports show efficacy w/
anxiety disorders.