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ELECTROCONVULSIV
E THERAPY
ASHISH DADHEECH
MSC NURSING FINAL YEAR
(M.H.N.)PSYCHIATRIC NURSING
BHILWARA ,RAJASTHAN
History of ECT
• Von Meduna (1934)- Autopsies of patients
w/ Seizure disorders and of patients w/
Schizophrenia.
• Difference in Glial cell proliferation
Chemically induced
seizures-
(camphor,
pentylenetetrazol)
Insulin Shock Therapy
• In the 1930’s , Dr Sakel developed Insulin
Shock Therapy
Cerletti and Bini (1934):
Electricity
Initially done without
muscle blocker or
anesthetic
Early ECT
• Assylums
• Few effective medications
• Many often severe side effects
• 1950’s- ether, and curare extract
developed (Abram Bennett- a psychiatrist
helped develop a method for extracting
curare).
• In 1950’s antidepressant and antipsychotic
meds introduced- significantly decreased
Electrophysiological
Principles
• Ohm’s Law: I=E/R (I=current, E=voltage,
and R=resistance)
• Dose of electricity in ECT= 100-500
milliCoulombs
• Brain has low impedance (resistance), skull
has very high impedance. Only 20% of
applied charge actually enters the brain.
• Seizure involves propagation of action
potentials in a large percentage of neurons.
Mechanism of Action
• Neurotransmitter levels all increased in
CSF after seizure. Results in down
regulation of Beta adrenergic receptors.
• During seizure- PET studies show an
increase in BBB permeability and in
cerebral blood flow and metabolism.
• After seizure, blood flow and metabolism is
decreased especially in the frontal lobes.
Research shows this correlated w/
Indications
• Major Depression w/ or w/o psychotic
features
• Bipolar disorder - manic or depressed
phase
• Acute or Catatonic Schizophrenia
• Some studies have shown efficacy in
treating OCD, Delirium, NMS, Chronic
pain syndromes, and intractable seizure
disorders
Major Depression
• Efficacy vs antidepressants
• When is it a first line treatment
consideration?
• Length of Antidepressant effect
• Maintenance ECT
Bipolar Mania
• Efficacy vs Lithium
• Indications for First Line Treatment:
• -Recent Myocardial Infarction w/ Acute
Mania
• -Pregnancy w/ Acute mania
Pre ECT Workup
• Physical Exam
• Head CT
• CXR
• CBC, Basic Chem
• EKG
• ? Spinal Films
Contraindications?
• No Absolute Contraindications
• Relative Contraindications: Recent MI,
Berry Aneurysm, Brain Mass, Increased
Intracranial Pressure
Treatments
• Premedicate w/ Glycopyrrolate, consider
short acting Beta blocker
• Patient not intubated
• Bite block
• Cuff leg to monitor sz
• EEG and EMG
• Length of sz- 20 sec to 1 min.
Number and Spacing of ECT
• 2-3x/wk- efficacy vs less memory
impairment
• 5-12 sessions/ treatment (although up to
20 is possible)
• Point of maximum improvement- no more
improvement after 2 further treatments.
Adverse Effects
• Mortality rate: .002% per treatment
session, .01% per patient.
• Sore Muscles
• Head ache
• Short term confusion/ delirium
• Memory
Transcranial Magnetic
Stimulation (TMS)
• Rt Frontal lobe- TMS pulses suppress
activity and causes happiness and increased
energy
• Left Frontal lobe- TMS pulses suppress
activity and leads to sadness
• 4/250 had seizure
• 10Hz stimulation 20x/day, 11/17 patients
w/ Major Depression showed significant
improvement.
TMS continued
• So far positive effects have not lasted as
long as positive effects from ECT
• Handful of case reports show efficacy w/
anxiety disorders.

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Ect topic which was expressed by ashish dadheech

  • 1. ELECTROCONVULSIV E THERAPY ASHISH DADHEECH MSC NURSING FINAL YEAR (M.H.N.)PSYCHIATRIC NURSING BHILWARA ,RAJASTHAN
  • 2. History of ECT • Von Meduna (1934)- Autopsies of patients w/ Seizure disorders and of patients w/ Schizophrenia. • Difference in Glial cell proliferation
  • 4. Insulin Shock Therapy • In the 1930’s , Dr Sakel developed Insulin Shock Therapy
  • 5. Cerletti and Bini (1934): Electricity Initially done without muscle blocker or anesthetic
  • 6. Early ECT • Assylums • Few effective medications • Many often severe side effects • 1950’s- ether, and curare extract developed (Abram Bennett- a psychiatrist helped develop a method for extracting curare). • In 1950’s antidepressant and antipsychotic meds introduced- significantly decreased
  • 7. Electrophysiological Principles • Ohm’s Law: I=E/R (I=current, E=voltage, and R=resistance) • Dose of electricity in ECT= 100-500 milliCoulombs • Brain has low impedance (resistance), skull has very high impedance. Only 20% of applied charge actually enters the brain. • Seizure involves propagation of action potentials in a large percentage of neurons.
  • 8. Mechanism of Action • Neurotransmitter levels all increased in CSF after seizure. Results in down regulation of Beta adrenergic receptors. • During seizure- PET studies show an increase in BBB permeability and in cerebral blood flow and metabolism. • After seizure, blood flow and metabolism is decreased especially in the frontal lobes. Research shows this correlated w/
  • 9. Indications • Major Depression w/ or w/o psychotic features • Bipolar disorder - manic or depressed phase • Acute or Catatonic Schizophrenia • Some studies have shown efficacy in treating OCD, Delirium, NMS, Chronic pain syndromes, and intractable seizure disorders
  • 10. Major Depression • Efficacy vs antidepressants • When is it a first line treatment consideration? • Length of Antidepressant effect • Maintenance ECT
  • 11. Bipolar Mania • Efficacy vs Lithium • Indications for First Line Treatment: • -Recent Myocardial Infarction w/ Acute Mania • -Pregnancy w/ Acute mania
  • 12. Pre ECT Workup • Physical Exam • Head CT • CXR • CBC, Basic Chem • EKG • ? Spinal Films
  • 13. Contraindications? • No Absolute Contraindications • Relative Contraindications: Recent MI, Berry Aneurysm, Brain Mass, Increased Intracranial Pressure
  • 14. Treatments • Premedicate w/ Glycopyrrolate, consider short acting Beta blocker • Patient not intubated • Bite block • Cuff leg to monitor sz • EEG and EMG • Length of sz- 20 sec to 1 min.
  • 15. Number and Spacing of ECT • 2-3x/wk- efficacy vs less memory impairment • 5-12 sessions/ treatment (although up to 20 is possible) • Point of maximum improvement- no more improvement after 2 further treatments.
  • 16. Adverse Effects • Mortality rate: .002% per treatment session, .01% per patient. • Sore Muscles • Head ache • Short term confusion/ delirium • Memory
  • 17. Transcranial Magnetic Stimulation (TMS) • Rt Frontal lobe- TMS pulses suppress activity and causes happiness and increased energy • Left Frontal lobe- TMS pulses suppress activity and leads to sadness • 4/250 had seizure • 10Hz stimulation 20x/day, 11/17 patients w/ Major Depression showed significant improvement.
  • 18. TMS continued • So far positive effects have not lasted as long as positive effects from ECT • Handful of case reports show efficacy w/ anxiety disorders.