The use of DNA sequence data has revolutionized the field of phylogenetics. Give at least two reasons why this is the case as compared to the the pre-DNA sequence era? Solution The major advantage of DNA sequence data is it has made available large number of potential characters for comparison and inferring the relationship. The number of nucleotide characters made available for comparison is tremendous due to the PCR reaction. The second major advantage of DNA sequence data is that substitution within structural genes are decoupled from its changes in morphology..