What does the following statement mean: There is co-translation translocation on a growing polypeptide chain. Solution In a part of protein synthesis, as the signal sequence emerges from the ribosome, it is recognized and bound by SRP (signal recognition particle), which escorts the complex to the ER membrane and SRP directs both the binding of the ribosome to the ER membrane and insersion of the nascent polypeptide into the transmembrane channel. Then, translation resumes and the growing polypeptide chain is translocated across the membrane. This process of tranlational machinary halts for a while and translocate to the ER and where translation will resume. This process is called co-translation translocation on a growing popypeptide chain..