1- Distinguish the locations and tissues among epidermis, dermis, and hypodermis layers. ? Solution The epidermis is the outermost layer of the skin, below which lies dermis and the hypodermis lies beneath the dermis. Keratinocytes in the epidermis helps to protect the inner layers from the outside environment. The dermis contains blood vessels, lymph vessels, hair follicles, and sweat glands. hypodermis consists of mostly adipose tissue and is the storage site of most body fat. It.