1. Herpesviral Reactivation:
A Key Step for
Ms.
Disease Development
Olga Gonzalez 10:30 AM Refreshments provided by Biology Honor Society
New Jersey Medical School
10:40 Seminar in MMM 106
& UPR-Cayey Alumnus *
Herpesviridae are enveloped, double-stranded
DNA viruses with relatively large complex ge- Thursday, Aug. 30
nomes. As of today, there are eight known human At the conclusion of
herpesviruses. A important feature of this virus is in MMM 106. Ms. Gonzalez’s seminar
its ability to establish latency and productive re- Mr. Bryan Vicente,
activation. In latency, the virus is able to establish Ms. Rossana Colon &
persistent infection for the lifetime of its host. Dur- Ms. Vivian Rodríguez-
]
ing reactivation, the virus undergoes to full viral will present a short talk
gene expression program, amplification of the viral concerning their summer
genome, and formation of mature viruses that can 2012 UMDNJ
disseminate within an infected host or be transmit- research experience.
ted to new hosts. Reactivation is an important step
for disease development in most of the herpesvirus.
Kaposi’s sarcoma-associated herpesvirus (KSHV)
also known as a Human Herpesvirus 8 (HHV-8) is
one of seven currently known human cancer virus-
es. Epidemiological studies had shown that KSHV
reactivation is an important step for cancer develop-
ment. Our lab focuses on understanding the mo-
lecular mechanisms of reactivation which will lead
to development of new therapeutic strategies and
diagnostic markers for KSHV infection.