What is alternative splicing? What is the difference between mRNA splicing and editing? Solution Alternative splicing is a process by which exons or portions of exons or noncoding regions within a pre-mRNA transcript are differentially joined or skipped, resulting in multiple protein isoforms being encoded by a single gene RNA splicing is a process that removes introns and joins exons in a primary transcript. Where as RNA editing is any process, other than splicing, that results in a change in the sequence of a RNA transcript such that it differs from the sequence of the DNA template.