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INHALA
LEBIHJAUH
Dr Salim S Thalib
INHALASI
OBAT MEL. SAL. NAPAS
BENTUK AEROSOL
TUJUAN TERAPI
LOKAL DAN SISTEMIK
DEFINISI
INHALASI MANFAAT
DOSIS RENDAH
EFEK SAMPING MINIMAL
ONSET CEPAT
INHALASI
INHALASI
TINGGI
RENDAH
INHALASI
LAMA
MINIMAL
KHASIAT OBAT
EFEK SISTEMIK
PENYERAPAN ORAL
PLASMA PROTEIN
INHALASI
DEPOSISI AEROSOL
IMPACTION
PADA PARU
SEDIMANTATION
DIFFUSION
INHALASI IMPACTION
INHALASI IMPACTION
SEDIMANTATION
INHALASI DIFFUSION
INHALASI DEPOSISI AEROSOL
PADA PARU
NASOPHARENGEAL
IMPACTION
TRACHEOBRONCHIAL
IMPACTION
(CENTRAL)
SEDIMANTATION
PULMONARY
SEDIMANTATION
DIFFUSION
(PERIPHERAL)
INHALASI UKURAN AEROSOL
MEDIAN DIAMETER-MICROMETERMASS MEDIAN DIAMETER-
MICROMETER
DEPOSITIONFRACTION
INHALASI KECEPATAN AEROSOL
TEND TO GET
TEND TO SLOWER FLOW
DEPOSITED IN UPPER AIRWAY
MINIMIZED UPPER AIRWAY
ENHANCHES DISTAL DELIVERY
HIGH VELOCITY
LOW VELOCITY
DEPOSITION
DEPOSITION
DEPOSITION
INHALASI TIPE PERNAPASAN
 BREATH HOLD AT END INSPIRATION
INCREASED CENTRAL
RAPID INHALATION
 SLOW INHALATION
INCREASED PERIPHERAL
INHALASI
ABSORPTION
ABSORPTION
TIPE PERNAPASAN
LOW SYSTEMIC
IMPACTION
VASCULER BED
HIGH SYSTEMIC
HUMIDIFICATION
NASAL BREATHING
 MOUTH BREATHING
INHALASI PENETRASI OBAT
SMALL AIRWAY MORE DEPOSITION
NARROWING AIRWAY :
VARIASI NORMAL JALAN NAPAS
 PENYAKIT DASAR PARU
KEDALAMPARU
BRONCHOSPAM, FIBROTIC, SECRET
MORE DEPOSITION IN CENTRAL
Martonen TK , Pharm Respir 1995, 12: 96
IN CENTRAL
INHALASI PENETRASI OBAT
KEDALAMPARU
ADULT CHILD CHILD WITH
INFLAMED AIRWAY
INHALASIFACTORS AFFECTING DELIVERY
OF AEROSOLIZED TO THE LUNG
FACTORSAFFECTINGDELIVERY
INHALASI
HASIL TERAPI MELALUI
EFEK TOPIKAL
PROSES
ABSORBSI
GABUNGAN
INHALASI
H.derendorf, Eur J 2006 ; 28 1042-1050
 On site activation in the lung.
 low oropharyngeal exposure.
 Negligible oral bioavallability.
 protein binding and rapid
clearance
Decrease local and
systemic side effects
small particle
High receptor binding activity.
 long pulmonary residence
time.
Lipid conjugation.
Increase or prolong the anti
inflammatory effects
PHARMACOKINETIC PHARMACODYNAMIC
EFEK SAMPING
INHALASI
APAKAH ADA
TERAPI
INHALASI
POTENTIAL LOCAL
INHALASIc
POTENTIAL SYSTEMIC
SKIN BRUISING
INHALASI PERANAN TERAPI
INHALASI PENYAKIT PARU
PERANANTERAPIINHALASIPADAPENYAKITPARU
PCP
P
INHALASI
METERED DOSEPRESSURIZED
INHALERS
DDRY POWDER
INHALERS
NNEBULIZER
JET & ULTRA SONIC
PMETERED DOSE
INHALERS
PRESSURIZED
INHALASI
PMETERED DOSE
INHALERS
INHALASI
PRESSURIZED
PMETERED DOSE
INHALERS
INHALASI
PRESSURIZED
PROPELLANTS
FORMULATION
ACTUATOR
CONTAINER
METERING VALVE
PMETERED DOSE
INHALERSCONTAINER
PRESSURIZED
PMETERED DOSE
INHALERSPROPELLANTS
PRESSURIZED
PMETERED DOSE
INHALERSACTUATOR
PRESSURIZED
PMETERED DOSE
INHALERSHow to use
PRESSURIZED
PMETERED DOSE
INHALERS
ADVANTAGES DISADVANTAGES
PRESSURIZED
PMETERED DOSE
INHALERS
SPACER DEVICES
PRESSURIZED
PMETERED DOSE
INHALERS
SPACER DEVICES
PRESSURIZED
INHALASI
PMETERED DOSE
INHALERS
SPACER DEVICES
PRESSURIZED
EFFECT OF DIAMETER AND SPACER LENGTH
ON AVAILABILITY OF DRUG
INHALASIWHY USE A WITH AN INHALER
INHALER ALONE, INHALER WITH SPACER,
MEDICINE ENDS UP IN MORE MEDICINE IS
THE MOUTH,
THROAT,STOMACH AND
DELIVERED TO THE
DEVICES
PMETERED DOSE
INHALERS
SPACER DEVICES
3 CATEGORIES :
SIMPLE TUBE
HOLDING CHAMBER
RESERVE - FLOW
PRESSURIZED
PMETERED DOSE
INHALERS
SIMPLE TUBE
SIMPLE TUBE EXTENTION
PRESSURIZED
TO ACTUATOR
SPACER
MOUTHPIECE
PMETERED DOSE
INHALERS
VALVE HOLDING PRESSURIZED
CHAMBER
PMETERED DOSE
INHALERS
VALVE HOLDING PRESSURIZED
CHAMBER
PMETERED DOSE
INHALERSHow to use
PRESSURIZED WITH SPACER
P- MDI WITH SPACER
RESERVE FLOWDEVICES
PMETERED DOSE
INHALERS
PRESSURIZED
INHALASI
INHALERS FOR CHILDREN
INHALASI
DRY POWDERINHALERS
INHALASI
DRY POWDERINHALERS
PORTABLE INSPIRATORY FLOW-
DRIVEN DEVICES THAT DELIVER
POWDER FORMULATIONS OF
INHALED DRUG TO LUNG
INHALASI
DRY POWDERINHALERS
INHALASI
DRY POWDERINHALERS
PRINCIPLES OF DRY POWDER INHALER DESIGN
INHALASI
DRY POWDERINHALERS
TURBOHALER
INHALASI
DRY POWDERINHALERS
PERBANDINGAN DEPOSISI OBAT
P-MDI 15 % DPI 32 % Thorsson et al, 1998
INHALASI
DRY POWDERINHALERS
INHALASI
INHALASI
DRY POWDERINHALERS
INHALASI
DRY POWDERINHALERS
INHALASI
DRY POWDERINHALERS
INHALASI
DRY POWDERINHALERS
INHALASI
DRY POWDERINHALERS
INHALASI
DRY POWDERINHALERS
INHALASI
DRY POWDERINHALERS
INHALASI
DRY POWDERINHALERS
INHALASI
DRY POWDERINHALERS
INHALASI
NEBULIZER
INHALASI
NEBULIZER
INHALASI
JET -NEBULIZER
INHALASI
JET -NEBULIZER
INHALASI
ULTRA SONIC -NEBULIZER
INHALASI
ULTRA SONIC -NEBULIZER
INHALASI
MIST INHALER
CHARACTERISTIC OF THE
AEROSOL GENERATORS
•KARAKTERISTIK
INHALASIIDEAL
OBAT
BIAYA TERAPI YANG EKONOMIS
DEPOSISI OROPHARYNX RENDAH
DEPOSISI PARU TINGGI
NYAMAN, KOORDINASI MINIMAL
INHALA
KE ALI
LEBIHJAUH
Dr Salim S Thalib

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