21. INHALASI PENETRASI OBAT
SMALL AIRWAY MORE DEPOSITION
NARROWING AIRWAY :
VARIASI NORMAL JALAN NAPAS
PENYAKIT DASAR PARU
KEDALAMPARU
BRONCHOSPAM, FIBROTIC, SECRET
MORE DEPOSITION IN CENTRAL
Martonen TK , Pharm Respir 1995, 12: 96
IN CENTRAL
25. INHALASI
H.derendorf, Eur J 2006 ; 28 1042-1050
On site activation in the lung.
low oropharyngeal exposure.
Negligible oral bioavallability.
protein binding and rapid
clearance
Decrease local and
systemic side effects
small particle
High receptor binding activity.
long pulmonary residence
time.
Lipid conjugation.
Increase or prolong the anti
inflammatory effects
PHARMACOKINETIC PHARMACODYNAMIC
42. INHALASIWHY USE A WITH AN INHALER
INHALER ALONE, INHALER WITH SPACER,
MEDICINE ENDS UP IN MORE MEDICINE IS
THE MOUTH,
THROAT,STOMACH AND
DELIVERED TO THE