Lorenzo Lotto painted Brother Gregorio Belo of Vicenza in 1547. The painting depicts Brother Gregorio, a member of the Hieronymites order, who is shown reading the Homilies of Saint Gregory the Great. He presses his fist against his chest in emulation of Saint Jerome, alluding to the penance of Saint Jerome and indicating Brother Gregorio's devotion to the order. In the background is a small depiction of the Crucifixion of Christ.