48. Know the filing regarding changes in chromosome structure a. Deletions i. terminal deletion ii. interstitial deletion iii. What contributes to the phenotypic consequences of deletion? iv. Cri du chat syndrome in humans b. Duplications i. Know how a duplication can arise. ii. more likely to have phenotypic effects if they learn that involve a large piece of chromosome iii. Duplications tend to have less harmful effects than deletions of comparable size iv. The contribution of duplication in the formation of gene families ex. Globin family v. Know what copy number variation refers to. And possible mechanisms.