4- Cystic fibrosis is an autosomal recessive Show work here- disease t.pdf
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4. Cystic fibrosis is an autosomal recessive Show work here: disease that affects the lungs and digestive system. A young couple named Sara and Daniel are interested in having a child. Neither Sara or Daniel nor either of their parents have cystic fibrosis, but Sara and Daniel both have siblings who have the disease. a) What are the genotypes of both Sara and Daniel's parents? b) What is the probability that Sara and Daniel are carriers for the disease? (Do the parental Punnett square and remember they DON'T have the disease, c) Using the probability from part b, what is the chance that, if they are both carriers, their child will have the disease? 5. A plant with the genotype BbCc is crossed Show work here: with a plant that has the genotype BBcc . What is the chance that the offspring will be either BbCc or BBcc ? 6. There is a couple named Louise and Robert. Show work here: They want to have exactly four children. Use the multiplication and addition rules to calculate the probability that Louise and Robert will have two girls and two boys in any order. (Hint: set up a table to help you determine all the different combinations possible.).
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Explain to them the probability of future offspring being normal or h.pdf
Explain to them the probability of future offspring being normal or having the disease (assume
that this is an autosomal disease). Be sure to tell them whether the disease is brought about by a
dominant or recessive allele and what fraction of their children (if any) could be carriers for the
disease. Be sure to incorporate the following into your explanation: DNA and chromosomes,
genes, dominant and recessive alleles, paired alleles on homologous chromosomes, and
segregation of alleles during gamete production. You can use words and drawings/diagrams.
Sally and Steve are concerned about cystic fibrosis. Neither of them has it, nor do their parents or
grandparents, yet each one has a sibling with cystic fibrosis (Sally\'s sister and Steve\'s brother).
Sally and Steve want to have a second child (the first one, age 4, appears unaffected). Jess and
Jessie want to get married and have children. Unfortunately, they have the same great-
grandmother (not the same great-grandfather). The great-grandmother suffered from polycystic
kidney disease. No other family members suffered from the disease, but they were told
(correctly) that their great-grandmother had passed on the possibility of the disease.
Solution
Ques-1:
Aetiology and Pathophysiology: It is autosomal recessive disease (mode of inheritance), which is
familial. Gene for cystic fibrosis is located on the chromosome 7 & this recessive allele
propogated to the offspring via parental gamete formation by reduction division & problem will
be at segregation of chromosomes. A protein called, CF transmembrane -this gene produces
regulator (CFTR). In case of Pleiotrophy one affects 2 or more apparently not linked phenotypic
traits there by more gene could be affected (cystic fibrosis).
For instance, Sally and Steve are concerned about cystic fibrosis. Neither of them has it, nor do
their parents or grandparents, yet each one has a sibling with cystic fibrosis (Sally\'s sister and
Steve\'s brother) i.e. both Sally & Steve are carriers of the disease. Therefore, 2/3 (67%), of
probability with unaffected child. Sally and Steve want to have a second child but the first child
age-4 has no cystic fibrosis
Cystic fibrosis is an autosomal recessive condition. In the given example, the unaffected parents
will have an affected children Assume that the gene coding for the normal allele is C, and the
gene coding for the cystic fibrosis is c and C is dominant over c. Now, cross between two
heterozygotes will have the offspring with the following genotypes.
Cc* Cc = CC, Cc, Cc, cc (means, 3/4th are unaffected (out of these 2/4 are carriers) and the ¼
are affected -having disease).
C
c
C
CC
Cc
c
Cc
cc
C
c
C
CC
Cc
c
Cc
cc.
5- Use the following pedigree to determine the probability that IV-1 (.docx
5. Use the following pedigree to determine the probability that IV-1 (child yet to be born) will have albinism. = has cystic fibrosis = = consanguineous marriage (cousins) 6. Using the following pedigrees, mark the genotype of each member and determine the mode of inheritance: B) C) I II III IV 1 2 0. Achondroplasia is an autosomal dominant form of dwarfism. People with achondroplasia are heterozygotes because carrying two copies of the dominant, mutant allele is fatal during embryogenesis. Two people with achondroplasia decide to start a family. A) Fill out a Punnett square for this couple. A) What is the probability that their first child born will be of average stature? B) What is the probability that this couple has two daughters with achondroplasia and one son of average stature in that order? C) What is the probability that this couple has two children with achondroplasia and one of average stature in any order?
.
Lesson 7 Single Gene Disorders (F) Kcr
Huntington's disease and cystic fibrosis are single gene disorders. Huntington's causes problems with muscle control and memory. Symptoms appear in middle age and worsen over time. Cystic fibrosis causes thick mucus to build up in the lungs and pancreas, leading to breathing issues and digestion problems. Both disorders are inherited in an autosomal recessive pattern, so carriers do not show symptoms but can pass the allele to their children.
Lesson 7 Huntingtons And Cystic Fibrosis
Huntington's disease and cystic fibrosis are single gene disorders. Huntington's causes uncontrolled movements and cognitive decline in middle age. Symptoms start with twitching and forgetfulness, and worsen over time. Cystic fibrosis causes thick mucus buildup in the lungs and digestive tract, leading to breathing issues and infections. It can affect people even if parents don't have the condition, as they may be carriers who pass on recessive alleles.
Lesson 7 Single Gene Disorders (H)
Huntington's disease is a genetic disorder that causes problems with muscle control and leads to forgetfulness, confusion, and inability to control movements. Symptoms first appear in middle age. Cystic fibrosis is also a genetic disorder that causes breathing and digestion problems due to thick mucus blocking the lungs and pancreas. Symptoms include breathing issues, chest infections, and malnutrition. Both disorders are inherited, but cystic fibrosis can occur even when parents do not have the condition if they are carriers of the defective gene.
BIOL 215 Final Exam Part 2
This document appears to be an exam for a biology course that covers human genetics and diversity. It includes questions asking the student to build a model of genetic inheritance using their own family tree. The student is then asked to answer questions about biological diversity and the concepts of race and ethnicity based on their model. The document discusses how classifications of race and ethnicity have changed over time and vary between countries, suggesting they are social rather than biological constructs.
Data ARn Rinod Group Typing Results Analysis Each persons A.pdf
Data ARn Rinod Group Typing Results Analysis Each person's ABO group is controlled by a pair
of alleles-one ABO controlling allele from the mother and one from the father. The ABO controlling
alleles A,B, and O can pair up six different ways, but they only produce four different ABO blood
groups: A,B. AB, and O. 1. What ABO controlling alleles could Kim give her children? 0/0 2. Which
baby or babies could not be Kimis? How do you know? BabiesLaboratory Investigation (continued)
STUDENT GUDE 3. What ABO controlling alliles could Andrea pive her didedrea? 4. Which
babies are fraternal tinins? Ilow da nou know for sure? 5. What must be the ABO blood group of
the tivins father? Explain and dras a Pannett square to support your explanation. 6. Fill out the
baby ID tags with the correct mother's namie..
Page 1Why Is He Different from Both Parents” by Liang and Ri.docx
Page 1“Why Is He Different from Both Parents?” by Liang and Rice
NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE
by
Jun Liang, Science Department, Borough of Manhattan Community College / City University of New York
William J. Rice, Simons Electron Microscopy Center, New York Structural Biology Center
Why Is He Different from Both Parents?
Part I – Human ABO Blood Type
“But I already know all this stuff! I’ll do well on the test tomorrow, I promise,” begged Kevin. He really wanted to go
out that night with his friend, but his mother had other ideas.
“No, absolutely not. You’re going to stay home and study; tomorrow’s test is very important,” his mother replied.
Kevin ended up staying home that night, reluctantly.
The next day Kevin met his best friend Peter. “How’s it going?” asked Peter.
“Not so good. We had a test today. I guess it went all right,” said Kevin.
“How’s your stomach doing? Is it still sore?” Peter asked.
“Oh, it’s better now. You know, there’s something weird going on. Last time I was in the hospital, neither of my parents
could donate blood to me. The doc said they aren’t a match for my blood type.”
“They don’t match? What do you mean?” Peter asked.
“Well, the doc said I’m type O positive, my mom is type A positive, and my dad is type B negative. We’re all different,
and I don’t get it. They’re my parents—I mean, I should inherit my blood type from at least one of them, if not both,
right?”
“That’s a good point,” Peter agreed. “Well, I’ve got a very cool science teacher, Ms. B. She would know better than us.
Let’s ask her. She has a class tomorrow. We can meet her afterward. What do you say?”
The next day, Kevein and Peter met Ms. B. and explained Kevin’s puzzle about his family’s blood types.
“Ah, good question,” replied Ms. B. “Let me explain how blood types work so that it will help you to understand why
your parents couldn’t donate blood to you and how you can all have different blood types in one and the same family.”
“The ABO blood group system is one of the most important systems that hospitals use to identify individuals for blood
transfusion. ABO stands for the type of carbohydrate that sits on the surface of red blood cells; it’s this carbohydrate
that allows cells to recognize themselves. They are also called surface markers. Positive (+) refers to the presence of
Rhesus (Rh) factor. Some individuals lack Rh factor, and they are negative (−). Rh factor is a predominant protein
surface marker on red blood cells.”
“Interesting. What is carbohydrate exactly? The stuff we eat, like bread and sugar?” Peter asked.
“Yes. Sugar is a carbohydrate and bread is made of lots of different carbohydrates. Red blood cells may have
carbohydrate A on the cell surface, which results in type A blood; but if they have carbohydrate B, then they become
type B blood. Some red blood cells have both carbohydrate A and B, which makes them have type AB blood. When
neither carbohydrate A nor B is prese ...
Recommended
Explain to them the probability of future offspring being normal or h.pdf
Explain to them the probability of future offspring being normal or having the disease (assume
that this is an autosomal disease). Be sure to tell them whether the disease is brought about by a
dominant or recessive allele and what fraction of their children (if any) could be carriers for the
disease. Be sure to incorporate the following into your explanation: DNA and chromosomes,
genes, dominant and recessive alleles, paired alleles on homologous chromosomes, and
segregation of alleles during gamete production. You can use words and drawings/diagrams.
Sally and Steve are concerned about cystic fibrosis. Neither of them has it, nor do their parents or
grandparents, yet each one has a sibling with cystic fibrosis (Sally\'s sister and Steve\'s brother).
Sally and Steve want to have a second child (the first one, age 4, appears unaffected). Jess and
Jessie want to get married and have children. Unfortunately, they have the same great-
grandmother (not the same great-grandfather). The great-grandmother suffered from polycystic
kidney disease. No other family members suffered from the disease, but they were told
(correctly) that their great-grandmother had passed on the possibility of the disease.
Solution
Ques-1:
Aetiology and Pathophysiology: It is autosomal recessive disease (mode of inheritance), which is
familial. Gene for cystic fibrosis is located on the chromosome 7 & this recessive allele
propogated to the offspring via parental gamete formation by reduction division & problem will
be at segregation of chromosomes. A protein called, CF transmembrane -this gene produces
regulator (CFTR). In case of Pleiotrophy one affects 2 or more apparently not linked phenotypic
traits there by more gene could be affected (cystic fibrosis).
For instance, Sally and Steve are concerned about cystic fibrosis. Neither of them has it, nor do
their parents or grandparents, yet each one has a sibling with cystic fibrosis (Sally\'s sister and
Steve\'s brother) i.e. both Sally & Steve are carriers of the disease. Therefore, 2/3 (67%), of
probability with unaffected child. Sally and Steve want to have a second child but the first child
age-4 has no cystic fibrosis
Cystic fibrosis is an autosomal recessive condition. In the given example, the unaffected parents
will have an affected children Assume that the gene coding for the normal allele is C, and the
gene coding for the cystic fibrosis is c and C is dominant over c. Now, cross between two
heterozygotes will have the offspring with the following genotypes.
Cc* Cc = CC, Cc, Cc, cc (means, 3/4th are unaffected (out of these 2/4 are carriers) and the ¼
are affected -having disease).
C
c
C
CC
Cc
c
Cc
cc
C
c
C
CC
Cc
c
Cc
cc.
5- Use the following pedigree to determine the probability that IV-1 (.docx
5. Use the following pedigree to determine the probability that IV-1 (child yet to be born) will have albinism. = has cystic fibrosis = = consanguineous marriage (cousins) 6. Using the following pedigrees, mark the genotype of each member and determine the mode of inheritance: B) C) I II III IV 1 2 0. Achondroplasia is an autosomal dominant form of dwarfism. People with achondroplasia are heterozygotes because carrying two copies of the dominant, mutant allele is fatal during embryogenesis. Two people with achondroplasia decide to start a family. A) Fill out a Punnett square for this couple. A) What is the probability that their first child born will be of average stature? B) What is the probability that this couple has two daughters with achondroplasia and one son of average stature in that order? C) What is the probability that this couple has two children with achondroplasia and one of average stature in any order?
.
Lesson 7 Single Gene Disorders (F) Kcr
Huntington's disease and cystic fibrosis are single gene disorders. Huntington's causes problems with muscle control and memory. Symptoms appear in middle age and worsen over time. Cystic fibrosis causes thick mucus to build up in the lungs and pancreas, leading to breathing issues and digestion problems. Both disorders are inherited in an autosomal recessive pattern, so carriers do not show symptoms but can pass the allele to their children.
Lesson 7 Huntingtons And Cystic Fibrosis
Huntington's disease and cystic fibrosis are single gene disorders. Huntington's causes uncontrolled movements and cognitive decline in middle age. Symptoms start with twitching and forgetfulness, and worsen over time. Cystic fibrosis causes thick mucus buildup in the lungs and digestive tract, leading to breathing issues and infections. It can affect people even if parents don't have the condition, as they may be carriers who pass on recessive alleles.
Lesson 7 Single Gene Disorders (H)
Huntington's disease is a genetic disorder that causes problems with muscle control and leads to forgetfulness, confusion, and inability to control movements. Symptoms first appear in middle age. Cystic fibrosis is also a genetic disorder that causes breathing and digestion problems due to thick mucus blocking the lungs and pancreas. Symptoms include breathing issues, chest infections, and malnutrition. Both disorders are inherited, but cystic fibrosis can occur even when parents do not have the condition if they are carriers of the defective gene.
BIOL 215 Final Exam Part 2
This document appears to be an exam for a biology course that covers human genetics and diversity. It includes questions asking the student to build a model of genetic inheritance using their own family tree. The student is then asked to answer questions about biological diversity and the concepts of race and ethnicity based on their model. The document discusses how classifications of race and ethnicity have changed over time and vary between countries, suggesting they are social rather than biological constructs.
Data ARn Rinod Group Typing Results Analysis Each persons A.pdf
Data ARn Rinod Group Typing Results Analysis Each person's ABO group is controlled by a pair
of alleles-one ABO controlling allele from the mother and one from the father. The ABO controlling
alleles A,B, and O can pair up six different ways, but they only produce four different ABO blood
groups: A,B. AB, and O. 1. What ABO controlling alleles could Kim give her children? 0/0 2. Which
baby or babies could not be Kimis? How do you know? BabiesLaboratory Investigation (continued)
STUDENT GUDE 3. What ABO controlling alliles could Andrea pive her didedrea? 4. Which
babies are fraternal tinins? Ilow da nou know for sure? 5. What must be the ABO blood group of
the tivins father? Explain and dras a Pannett square to support your explanation. 6. Fill out the
baby ID tags with the correct mother's namie..
Page 1Why Is He Different from Both Parents” by Liang and Ri.docx
Page 1“Why Is He Different from Both Parents?” by Liang and Rice
NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE
by
Jun Liang, Science Department, Borough of Manhattan Community College / City University of New York
William J. Rice, Simons Electron Microscopy Center, New York Structural Biology Center
Why Is He Different from Both Parents?
Part I – Human ABO Blood Type
“But I already know all this stuff! I’ll do well on the test tomorrow, I promise,” begged Kevin. He really wanted to go
out that night with his friend, but his mother had other ideas.
“No, absolutely not. You’re going to stay home and study; tomorrow’s test is very important,” his mother replied.
Kevin ended up staying home that night, reluctantly.
The next day Kevin met his best friend Peter. “How’s it going?” asked Peter.
“Not so good. We had a test today. I guess it went all right,” said Kevin.
“How’s your stomach doing? Is it still sore?” Peter asked.
“Oh, it’s better now. You know, there’s something weird going on. Last time I was in the hospital, neither of my parents
could donate blood to me. The doc said they aren’t a match for my blood type.”
“They don’t match? What do you mean?” Peter asked.
“Well, the doc said I’m type O positive, my mom is type A positive, and my dad is type B negative. We’re all different,
and I don’t get it. They’re my parents—I mean, I should inherit my blood type from at least one of them, if not both,
right?”
“That’s a good point,” Peter agreed. “Well, I’ve got a very cool science teacher, Ms. B. She would know better than us.
Let’s ask her. She has a class tomorrow. We can meet her afterward. What do you say?”
The next day, Kevein and Peter met Ms. B. and explained Kevin’s puzzle about his family’s blood types.
“Ah, good question,” replied Ms. B. “Let me explain how blood types work so that it will help you to understand why
your parents couldn’t donate blood to you and how you can all have different blood types in one and the same family.”
“The ABO blood group system is one of the most important systems that hospitals use to identify individuals for blood
transfusion. ABO stands for the type of carbohydrate that sits on the surface of red blood cells; it’s this carbohydrate
that allows cells to recognize themselves. They are also called surface markers. Positive (+) refers to the presence of
Rhesus (Rh) factor. Some individuals lack Rh factor, and they are negative (−). Rh factor is a predominant protein
surface marker on red blood cells.”
“Interesting. What is carbohydrate exactly? The stuff we eat, like bread and sugar?” Peter asked.
“Yes. Sugar is a carbohydrate and bread is made of lots of different carbohydrates. Red blood cells may have
carbohydrate A on the cell surface, which results in type A blood; but if they have carbohydrate B, then they become
type B blood. Some red blood cells have both carbohydrate A and B, which makes them have type AB blood. When
neither carbohydrate A nor B is prese ...
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