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WallerianDegenration

HEMOSTASIS

Health & Medicine

Dubravka Šipuš, 2nd year
2013/2014
Mentor: A. Žmegač Horvat

 Hemostasis – prevention of blood loss
 Mechanisms:
1) Vascular constriction
2) Formation of a platelet plug
3) Formation of a blood clot
4) Growth of fibrous tissue

 Fast process
 Procoagulants and anticoagulants
 Complex cascade of chemical reactions
 Blood coagulation factors

 Formation of prothrombin activator
 Extrinsic pathway
 Intrinsic pathway

 Endothelial surface factors (smoothness,
glycocalyx, thrombomodulin)
 Antithrombin III - heparin cofactor
 Coumarin (warfarin)
 Citrate ion, oxalate

 Vitamin K deficiency
 Diseases of the liver
 Hemophilia
 Thrombocytopenia

 Hemophilia A - abnormality or deficiency of
Factor VIII
 Recessive sex-linked, X chromosome
disorder

 Guyton, Hall: Textbook of Medical Physiology

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