4. Nasdaq
Celgene
Why does CELG trade at a discount to its
peers despite having average market share
and superior profitability?
We believe that the market has
overreacted to Celgene’s overreliance
on its flagship drug, Revlimid
We believe that the new and future
drug pipeline have not been priced in
to Celgene’s stock price
INVESTMENT THESIS
OUTLINE INVESTMENT THESIS COMPANY OVERVIEW COMPETITIVE OVERVIEW RISK OVERVIEW RECOMMENDATIONFINANCIAL OVERVIEW
6. COMPANY OVERVIEW
HEMATOLOGICAL & SOLID TUMOR CANCERS
multiplemyeloma
chroniclymphocyte
non-hodgkin’slymphoma
glioblastoma
ovariancancer
myelodysplasticsyndromes
pancreaticcancer
prostatecancer12.7 million
diagnosed each
year
Celgene is a biopharmaceutical
company focusing on the discovery,
development and commercialization
of products for the treatment of
cancer and other severe immune,
inflammatory conditions.
OUTLINE INVESTMENT THESIS COMPANY OVERVIEW COMPETITIVE OVERVIEW RISK OVERVIEW RECOMMENDATIONFINANCIAL OVERVIEW
7. OUTLINE INVESTMENT THESIS COMPANY OVERVIEW COMPETITIVE OVERVIEW RISK OVERVIEW RECOMMENDATION
COMPANY OVERVIEW
ABRAXANE® $1.2 B $1.3 B
ISTODAX®
OTEZLA® $1.0 B $1.7 B
POMALYST® $1.3 B $1.5 B
REVLIMID® $6.8 B $7.9 B
THALOMID®
VIDAZA®
2016 2017
$938 M
16.8%
CELGENE market cap $93.36 B
TOTAL biopharma market cap $811.5 B
CELGENE has 11.5% of the market space
FINANCIAL OVERVIEW
8. OUTLINE INVESTMENT THESIS COMPANY OVERVIEW COMPETITIVE OVERVIEW RISK OVERVIEW RECOMMENDATIONFINANCIAL OVERVIEW
COMPANY OVERVIEW
I N D U S T R Y O V E R V I E W
“…under a Trump presidency the likelihood of new
legislation controlling the pricing of drugs and
healthcare services is severely decreased.”
- Business Insider
9. Barriers to
Entry
Large startup costs
to purchase
research and design
facilities and servers
to structure data
Regulatory issues
and initial
regulations make
the startup path
difficult.
Bargaining
Power of
Buyers
Low switching costs,
but there are
contracts that need
to be honored
sometimes
Some drugs have
moderate variations
that are potentially
significant.
Intensity of
Rivalry
Competition is
based on price only
when drugs are
(nearly) identical.
There are several
types of disease
needs, so
differentiation is
somewhat common.
Threat of
Substitutes
Moderate amount
of substitutes
available for
common diseases
Few substitutes
available for
lower-in-demand
and/or recently
discovered
diseases
Bargaining
Power of
Suppliers
Few suppliers for
certain drugs that
treat less common
and/or recently
discovered
diseases
The demand
needs of this
industry generally
allows high pricing
and margins.
HIGH MODERATE MODERATE MODERATE HIGH
PORTER’S FIVE MARKET FORCES
COMPANY OVERVIEW
I N D U S T R Y O V E R V I E W
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18. OUTLINE INVESTMENT THESIS COMPANY OVERVIEW COMPETITIVE OVERVIEW RISK OVERVIEW RECOMMENDATIONFINANCIAL OVERVIEW
RISK OVERVIEW
• Pricing of Revlimid: $100K = Very High
• 65% of Celgene’s total sales is from
Revlimid
Amgen’s
Kyprolis: near
future less
expensive
alternative
Heightened
competition
for Revlimid
Loss of sales
Price
cuts
Loss in
market
share
R I S K O N E
Over-dependent Revenue Stream and Potential Competition
65%
35%
Celgene Total Sales
Revlimid Other
19. OUTLINE INVESTMENT THESIS COMPANY OVERVIEW COMPETITIVE OVERVIEW RISK OVERVIEW RECOMMENDATIONFINANCIAL OVERVIEW
• New drugs expected to hit market soon
• FDA is increasingly lenient
Celgene Pipeline: Most
drugs in trial phase
three and four
• Protect market power of Revlimid
• Stronger diversification of 3-4 main
drugs by 2025
Exclusive patent
rights for Revlimid by
Celgene through
2025
RISK OVERVIEW
R I S K O N E – M I T I G A T I O N
20. Anti-trust Allegations from Competitors
Celgene’s refusal to
allow competitors to
purchase drugs
Competitors cannot
perform routine testing
Competitors cannot
develop generic version
FTC filed a case favoring
Mylan
Potential Result: Loss of
“Monopolization” of
Revlimid and Thalomid
OUTLINE INVESTMENT THESIS COMPANY OVERVIEW COMPETITIVE OVERVIEW RISK OVERVIEW RECOMMENDATIONFINANCIAL OVERVIEW
RISK OVERVIEW
R I S K T W O
21. • Used as a measure to slow down competitor’s
progress
• Very unlikely for anti-trust allegations to pass
through
• Ex: Abbot Laboratories vs Teva Pharaceuticals
Anti-trust allegations
very common in
biotechnology and
pharmaceutical
industries
OUTLINE INVESTMENT THESIS COMPANY OVERVIEW COMPETITIVE OVERVIEW RISK OVERVIEW RECOMMENDATIONFINANCIAL OVERVIEW
RISK OVERVIEW
R I S K T W O – M I T I G A T I O N
22. Drug-counterfeiting firms
sell drugs at lower price
Inaccurate and impure
drug manufacturing
Negative Publicity to
Celgene
Loss of sales and market
share for Celgene
Drug-counterfeiting Firms
Ex: Turkish Drug wholesaler pleaded guilty for
counterfeited Avastin cancer drug.
OUTLINE INVESTMENT THESIS COMPANY OVERVIEW COMPETITIVE OVERVIEW RISK OVERVIEW RECOMMENDATIONFINANCIAL OVERVIEW
RISK OVERVIEW
R I S K T H R E E
23. • “Track and Trace” Technology
• Monitor supply chain using
technology
“Celgene has initiated
researching and
executing new strategies
and technological
developments to deter
counterfeiting”
•Partnership for Safe Medicines (PhRMA)
•Coalition Against Counterfeiting and Piracy (CACP)
•FDA: Combating Counterfeit Drugs
•International Anti-counterfeiting Coalition (IACC)
•European Alliance for Access to Safe Medicines
(EAASM)
•Ex: Legislation requiring tamper-proof security
technology on each medical package
“Celgene works
closely with
regulatory bodies,
law enforcement
agencies, their
industry peers, and
consumer protection
authorities
worldwide.”
OUTLINE INVESTMENT THESIS COMPANY OVERVIEW COMPETITIVE OVERVIEW RISK OVERVIEW RECOMMENDATIONFINANCIAL OVERVIEW
RISK OVERVIEW
R I S K T H R E E – M I T I G A T I O N
25. OUTLINE INVESTMENT THESIS COMPANY OVERVIEW COMPETITIVE OVERVIEW RISK OVERVIEW RECOMMENDATIONFINANCIAL OVERVIEW
RECOMMENDATION
From our qualitative analysis and
quantitative valuation on $CELG as well
as its competitors and overall industry,
we recommend a long on $CELG.