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Valliappan Kannappan
Valliappan Kannappan
VALLIAPPAN K
Professor of Quality Assurance (Retd.)
Department of Pharmacy
Annamalai University
INDIA
Chirality Timeline 2021
10 min.
Valliappan Kannappan
Valliappan Kannappan
Discovered optical activity / rotation.
Discovered optical activity / rotation.
1815
1815
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C
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A
A
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French Physicist, Astronomer
& Mathematician
Chirality Timeline 2021
First achieved separation (Physical)
First achieved separation (Physical)
of enantiomers
of enantiomers (
(
 after 30 yrs.).
after 30 yrs.).
1848
1848
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I
M
M
E
E
L
L
I
I
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N
E
E
French Biologist,
Microbiologist and Chemist
Valliappan Kannappan
Valliappan Kannappan
Put forward stereochemical theory of isomerism
on a 3D basis; tetrahedral Carbon. First winner
of Nobel prize in Chemistry (1901).
1874
1874 Dutch Chemist
Dutch Chemist
Molecular chirality principle was established over a century ago (145 yrs.)
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Chirality Timeline 2021
Le Bel
1874
1874 French Chemist
French Chemist
Postulated tetrahedral arrangements of groups
around a saturated carbon atom
Molecular chirality principle was established over a century ago (145 yrs.)
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I
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M
E
E
L
L
I
I
N
N
E
E
Valliappan Kannappan
Valliappan Kannappan
1894
1894
Visualized the fit between E & S
in terms of lock & key; identified
16 aldohexoses
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C
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R
R
A
A
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L
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Chirality Timeline 2021
Kelvin
Introduced the term chiral
1904
1904
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M
E
E
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L
I
I
N
N
E
E
Valliappan Kannappan
Valliappan Kannappan
First offered definite example of a difference bet.
enantiomers of a chiral molecule ( 50 yrs.
after Van’t -Le Bel theory of isomerism ).
1926
1926 Scottish Pharmacologist
Cushny
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C
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H
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I
R
R
A
A
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L
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Chirality Timeline 2021
(-)-Hyoscyamine twice as active as ()-form - 1904
(-)-Adrenaline twice potency of ()-form as vasoconstrictor - 1908
(-)-Adrenaline 12 -15 X more potent than (+)-form on sympathetic vessels
-
Biological relations of optically isomeric substances (1926);
Foundation for Chiral Pharmacology
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M
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E
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L
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I
N
N
E
E
Valliappan Kannappan
Valliappan Kannappan
Reinforced the term chiral into
Reinforced the term chiral into
the literature
the literature
1965
1965
Kurt Mislow
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C
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A
A
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L
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Y
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Chirality Timeline 2021
Devised R/S and Z/E notation
1966
1966
1974: Nobel prize in chemistry;
research into stereochemistry of
alkaloids, antibiotics, enzymes
I
I
M
M
E
E
L
L
I
I
N
N
E
E
Valliappan Kannappan
Valliappan Kannappan
K. Barry Sharpless
William S. Knowles
William S. Knowles
Nobel Laureates in Chemistry
Nobel Laureates in Chemistry -
- 2001
2001
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Chirality Timeline 2021
Royoji Noyori
K. Barry Sharpless
William S. Knowles
William S. Knowles
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M
M
E
E
L
L
I
I
N
N
E
E
Valliappan Kannappan
Valliappan Kannappan
¼ of the prize
St. Louis, MO, USA
b 1917; 84
L-DOPA – industrial
L
A
U
R
E
A
T
E
Chirality Timeline 2021
William S. Knowles
William S. Knowles
L-DOPA – industrial
production
“chirally catalyzed hydrogenation reactions”
Valliappan Kannappan
Valliappan Kannappan
¼ of the prize
Nagoya University,
Japan
b 1938; 63
L
A
U
R
E
A
T
E
Chirality Timeline 2021
Royoji Noyori
Ru-BINAP; (R)-1,2-
Propandiol; levofloxacin
“chirally catalyzed hydrogenation reactions”
Valliappan Kannappan
Valliappan Kannappan
½ of the prize
The Scripps Research
Institute, CA, USA
b 1941; 60
L
A
U
R
E
A
T
E
Chirality Timeline 2021
K. Barry Sharpless
Glycidol; -blockers
“chirally catalyzed oxidation reactions.”
Valliappan Kannappan
Valliappan Kannappan
Thanks for your time …
Thanks for your time … remembering all these great scientists
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Chirality Timeline 2021
valliappan
valliappan
Chirally Yours
Chirally Yours
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Chirality Timeline

  • 1. Valliappan Kannappan Valliappan Kannappan VALLIAPPAN K Professor of Quality Assurance (Retd.) Department of Pharmacy Annamalai University INDIA Chirality Timeline 2021 10 min.
  • 2. Valliappan Kannappan Valliappan Kannappan Discovered optical activity / rotation. Discovered optical activity / rotation. 1815 1815 C C H H I I R R A A L L I I T T Y Y T T I I French Physicist, Astronomer & Mathematician Chirality Timeline 2021 First achieved separation (Physical) First achieved separation (Physical) of enantiomers of enantiomers ( (  after 30 yrs.). after 30 yrs.). 1848 1848 I I M M E E L L I I N N E E French Biologist, Microbiologist and Chemist
  • 3. Valliappan Kannappan Valliappan Kannappan Put forward stereochemical theory of isomerism on a 3D basis; tetrahedral Carbon. First winner of Nobel prize in Chemistry (1901). 1874 1874 Dutch Chemist Dutch Chemist Molecular chirality principle was established over a century ago (145 yrs.) C C H H I I R R A A L L I I T T Y Y T T I I Chirality Timeline 2021 Le Bel 1874 1874 French Chemist French Chemist Postulated tetrahedral arrangements of groups around a saturated carbon atom Molecular chirality principle was established over a century ago (145 yrs.) I I M M E E L L I I N N E E
  • 4. Valliappan Kannappan Valliappan Kannappan 1894 1894 Visualized the fit between E & S in terms of lock & key; identified 16 aldohexoses C C H H I I R R A A L L I I T T Y Y T T I I Chirality Timeline 2021 Kelvin Introduced the term chiral 1904 1904 I I M M E E L L I I N N E E
  • 5. Valliappan Kannappan Valliappan Kannappan First offered definite example of a difference bet. enantiomers of a chiral molecule ( 50 yrs. after Van’t -Le Bel theory of isomerism ). 1926 1926 Scottish Pharmacologist Cushny C C H H I I R R A A L L I I T T Y Y T T I I Chirality Timeline 2021 (-)-Hyoscyamine twice as active as ()-form - 1904 (-)-Adrenaline twice potency of ()-form as vasoconstrictor - 1908 (-)-Adrenaline 12 -15 X more potent than (+)-form on sympathetic vessels - Biological relations of optically isomeric substances (1926); Foundation for Chiral Pharmacology I I M M E E L L I I N N E E
  • 6. Valliappan Kannappan Valliappan Kannappan Reinforced the term chiral into Reinforced the term chiral into the literature the literature 1965 1965 Kurt Mislow C C H H I I R R A A L L I I T T Y Y T T I I Chirality Timeline 2021 Devised R/S and Z/E notation 1966 1966 1974: Nobel prize in chemistry; research into stereochemistry of alkaloids, antibiotics, enzymes I I M M E E L L I I N N E E
  • 7. Valliappan Kannappan Valliappan Kannappan K. Barry Sharpless William S. Knowles William S. Knowles Nobel Laureates in Chemistry Nobel Laureates in Chemistry - - 2001 2001 C C H H I I R R A A L L I I T T Y Y T T I I Chirality Timeline 2021 Royoji Noyori K. Barry Sharpless William S. Knowles William S. Knowles I I M M E E L L I I N N E E
  • 8. Valliappan Kannappan Valliappan Kannappan ¼ of the prize St. Louis, MO, USA b 1917; 84 L-DOPA – industrial L A U R E A T E Chirality Timeline 2021 William S. Knowles William S. Knowles L-DOPA – industrial production “chirally catalyzed hydrogenation reactions”
  • 9. Valliappan Kannappan Valliappan Kannappan ¼ of the prize Nagoya University, Japan b 1938; 63 L A U R E A T E Chirality Timeline 2021 Royoji Noyori Ru-BINAP; (R)-1,2- Propandiol; levofloxacin “chirally catalyzed hydrogenation reactions”
  • 10. Valliappan Kannappan Valliappan Kannappan ½ of the prize The Scripps Research Institute, CA, USA b 1941; 60 L A U R E A T E Chirality Timeline 2021 K. Barry Sharpless Glycidol; -blockers “chirally catalyzed oxidation reactions.”
  • 11. Valliappan Kannappan Valliappan Kannappan Thanks for your time … Thanks for your time … remembering all these great scientists C C H H I I R R A A L L I I T T Y Y T T I I Chirality Timeline 2021 valliappan valliappan Chirally Yours Chirally Yours I I M M E E L L I I N N E E