SIREN overview for Barsan Emergency Medicine Research Forum 2022

1. Update
Barsan Research Day
April 2022

2. Evolution
2017

3. Dr. Barsan
Me

4. Design principles and organizational values
•Focus on early treatment.
•Focus on meaningful outcomes for patients.
•Focus on efficiency.
•Focus on collaboration.
•Focus on transforming the clinical trials enterprise.

6. SIREN Clinical Trials

7. Clinical Trial Summary
and Rough Budget
Trial Ideas
(from
anybody)
Scientifically and
Clinically Important
Questions and
Observations
Institute
Pre-approval
to submit
Grant
application(s)
Collaborative
Grant Application
and Protocol
Development
with input from
Sites, Patients,
and Others
NIH Study
Section
Revise
Grant Award
Grant Award to
Scientific PI’s
Institution with
major subaward
to CCC
DCC may be
paired grant or
subaward
depending on
Institute
Begin discussions with NIH
program officers early
NIH program officers will
evaluate the fit for the
Institute
Begin discussions with SIREN leadership early as
well.
SIREN leadership will evaluate fit for the network,
contribute to concept, and relay to site PI’s
SIREN will NOT be a layer of scientific peer review
Institute Council

8. Accomplishments
Pipeline
Renewal

11. Bio HOBIT

14. Pipeline and
Other Activity

15. SIREN Projects: Ongoing or Being Developed

16. SIREN Projects: Development Redirected or Deferred

17. SIREN Projects: Ancillary, Affiliated, Grants and Supplements

18. SIREN Projects: Distributions of Conditions Studied

19. Expand the portfolio
Continued outreach and inclusiveness
Innovate and share methods and practices
Renewal and the Future