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 Gall Bladder Disorders
› Cholelithiasis
› Cholecystitis
 Acute Pancreatitis
 Chronic Pancreatitis
 Obesity
 Women especially who have had multiple
pregnancies or who are of Native American
or U.S. Southwestern Hispanic Ethnicity
 Frequent changes in weight
 Rapid weight loss
 High dose estrogen
 Ileal resection or disease
 Cystic Fibrosis
 Diabetes Mellitus
 Formation of calculi in the gallbladder
 Results from the changes in bile
components or bile stasis, which may be
associated with such factors as infection,
cirrhosis, and pancreatitis.
 Acute or chronic inflammation of the
gallbladder
 Obstruction of the cystic duct by
impacted gallstone
 Tissue damage due to trauma, massive
burns, or surgery
 Gram-negative septicemia
 Overuse of opioid analgesics
CholelithiasisCholecystitis
 Episodic, cramping pain in the RUQ of the
abdomen or the epigastrium, possibly radiating
to the back near the right scapular tip
 Nausea and vomiting
 Fat intolerance
 Fever and leukocytosis
 Jaundice
 Epigastric distress
 Biliary colic
 Tenderness and rigidity in the RUQ elicited on palpation
 Murphy’s sign – Pain on taking a deep breath when the examiner’s
fingers are on the approximate location on the gallbladder
 Fever
 Nausea and vomiting
 Fat intolerance
 Heart burn
 Flatulence
 Vitamin deficiency
 Abdominal X-ray
 Ultrasonography– diagnostic procedure of choice
 Cholescintigraphy – radioactive agent is administered intravenously
 Cholecystography – iodide containing contrast agent is administered
before x-ray
 Endoscopic Retrogade Cholangiopancreatography
(ERCP)
› Permits direct visualization of structures that previously could be seen only
during laparotomy
› A fiberoptic duodenoscope, with side-viewing apparatus is inserted into the
duodenum. The ampulla of Vater is catheterized, and the biliary tree is
injected with contrast agent
 Ultrasonography – diagnostic procedure of choice
 Cholescintigraphy – radioactive agent is administered
intravenously
 Cholecystography – iodide containing contrast agent is
administered before x-ray
 Endoscopic Retrogade Cholangiopancreatography
(ERCP)
› Permits direct visualization of structures that previously could be seen only
during laparotomy
› A fiberoptic duodenoscope, with side-viewing apparatus is inserted into the
duodenum. The ampulla of Vater is catheterized, and the biliary tree is
injected with contrast agent
 Pharmacologic Management
› Ursodeoxycholic acid (UDCA [URSO, Actigall])
– dissolve small radiolucent gall stone
› Administer prescribed medication, which may
include analgesics [Morphine Sulfate] and
antacids
 Nutritional Therapy
› Low fat liquids
› High in protein and carbohydrates
 Intra-corporeal Lithotripsy
› Stones in the gallbladder or common bile duct
may be fragmented by means of laser pulse
technology
 Extracorpeal Shockwave Lithotripsy
› Non-invasive procedure uses repeated shock
waves directed at the gallstones in the
gallbladder or common bile duct to fragment
the stones
 Laparoscopic Cholecystectomy
› Performed through a small incision or puncture made
through the abdominal wall at the umbilicus
 Cholecystectomy
› Gall bladder is removed through an abdominal incision
after the cystic duct and artery are ligated
› A drain is placed close to the gall bladder if there is a
bile leak, removed after 24 hours
› Bile duct injury-serious complication
 Choledochostomy
› Making an incision in the common bile duct for removal
of stones
 Laparoscopic Cholecystectomy
› Performed through a small incision or puncture
made through the abdominal wall at the
umbilicus
 Cholecystectomy
› Gall bladder is removed through an abdominal
incision after the cystic duct and artery are
ligated
› A drain is placed close to the gall bladder if
there is a bile leak, removed after 24 hours
› Bile duct injury-serious complication
 Choledochostomy
› Making an incision in the common bile duct for
removal of stones
 Self- digestion of the pancreas by its own
proteolytic enzymes, principally trypsin
 Inflammation of the pancreas ranging
from a relatively mild, self-limiting
disorder to rapidly fatal, acute,
hemorrhagic pancreatitis
 Alcoholism
 Cholecystitis
 Surgery involving or near the pancreas
 Abdominal tenderness with back pain
 GI problems, such as nausea, vomiting, diarrhea
and steatorrhea
 Fever
 Jaundice
 Mental confusion
 Flank or umbilical bruising
 Hypotension
 Signs of hypovolemia
 Internal bleeding
 Cullen’s Sign – bluish discoloration around the umbilicus
 Turner’s Sign – discoloration lateral of the trunk or
posteriorly
 Elevated amylase
 Lipase
 Increase WBC Levels
 Hypocalcemia
 Administer prescribed medications, which
include opioid or non-opioid analgesics,
histamine receptor antagonist, PPI
 Drug of Choice for pain: Morphine Sulfate
 The client should avoid oral intake to
inhibit pancreatic stimulation and
secretion of pancreatic enzymes
 Maintain fluid and electrolyte balance
 Promote adequate nutrition
 Progressive pancreatic inflammation resulting in
permanent structural damage to pancreatic
tissue
 Results from repeated episodes of acute
pancreatitis
 More than half of chronic pancreatitis cases are
associated with alcoholism
 Long term alcohol consumption causes
hypersecretion of protein in pancreatic
secretions, resulting in protein plugs and calculi
within the pancreatic ducts
 Recurring attacks of severe upper
abdominal and back pain
 Weight loss
 Steatorrhea
Stools become frequent, frothy, and foul-
smelling because of impaired fat digestion,
which results in stools with a high fat content
 Anorexia
 Serum lipase and amylase elevated
 WBC elevated
 ERCP
› Detects pancreatic calcification
 Glucose tolerance test values are
abnormal
 Administer prescribed medications, which
include pancreatic enzymes
 Non-opioid pain medications, antacids, histamine
receptor antagonist, & PPI
 Provide symptomatic treatment focusing on
relieve pain, promoting comfort, and treating new
attacks
 Emphasize then importance of avoiding alcohol,
caffeine, and foods that tend to cause abdominal
discomfort
 Manage any endocrine insufficiency such as DM,
by initiating dietary and insulin or oral
hypoglycemic therapy
 Pancreatic jejunostomy (Roux-en-Y)
› Joining of the pancreatic duct to the jejunum
› Allows drainage of the pancreatic duct to the
jejunum
 A Whipple resection
(pancreaticoduodenectomy)
› Can be carried out to relieve the pain of
chronic pancreatitis
 Pancreatic jejunostomy (Roux-en-Y)
› Joining of the pancreatic duct to the jejunum
› Allows drainage of the pancreatic duct to the
jejunum
 A Whipple resection
(pancreaticoduodenectomy)
› Can be carried out to relieve the pain of
chronic pancreatitis
Hepatobiliary System (Part 2)

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Hepatobiliary System (Part 2)

  • 1.
  • 2.  Gall Bladder Disorders › Cholelithiasis › Cholecystitis  Acute Pancreatitis  Chronic Pancreatitis
  • 3.  Obesity  Women especially who have had multiple pregnancies or who are of Native American or U.S. Southwestern Hispanic Ethnicity  Frequent changes in weight  Rapid weight loss  High dose estrogen  Ileal resection or disease  Cystic Fibrosis  Diabetes Mellitus
  • 4.
  • 5.  Formation of calculi in the gallbladder
  • 6.  Results from the changes in bile components or bile stasis, which may be associated with such factors as infection, cirrhosis, and pancreatitis.
  • 7.
  • 8.  Acute or chronic inflammation of the gallbladder
  • 9.  Obstruction of the cystic duct by impacted gallstone  Tissue damage due to trauma, massive burns, or surgery  Gram-negative septicemia  Overuse of opioid analgesics
  • 10. CholelithiasisCholecystitis  Episodic, cramping pain in the RUQ of the abdomen or the epigastrium, possibly radiating to the back near the right scapular tip  Nausea and vomiting  Fat intolerance  Fever and leukocytosis  Jaundice  Epigastric distress  Biliary colic  Tenderness and rigidity in the RUQ elicited on palpation  Murphy’s sign – Pain on taking a deep breath when the examiner’s fingers are on the approximate location on the gallbladder  Fever  Nausea and vomiting  Fat intolerance  Heart burn  Flatulence  Vitamin deficiency
  • 11.  Abdominal X-ray  Ultrasonography– diagnostic procedure of choice  Cholescintigraphy – radioactive agent is administered intravenously  Cholecystography – iodide containing contrast agent is administered before x-ray  Endoscopic Retrogade Cholangiopancreatography (ERCP) › Permits direct visualization of structures that previously could be seen only during laparotomy › A fiberoptic duodenoscope, with side-viewing apparatus is inserted into the duodenum. The ampulla of Vater is catheterized, and the biliary tree is injected with contrast agent
  • 12.  Ultrasonography – diagnostic procedure of choice
  • 13.  Cholescintigraphy – radioactive agent is administered intravenously
  • 14.  Cholecystography – iodide containing contrast agent is administered before x-ray
  • 15.  Endoscopic Retrogade Cholangiopancreatography (ERCP) › Permits direct visualization of structures that previously could be seen only during laparotomy › A fiberoptic duodenoscope, with side-viewing apparatus is inserted into the duodenum. The ampulla of Vater is catheterized, and the biliary tree is injected with contrast agent
  • 16.  Pharmacologic Management › Ursodeoxycholic acid (UDCA [URSO, Actigall]) – dissolve small radiolucent gall stone › Administer prescribed medication, which may include analgesics [Morphine Sulfate] and antacids  Nutritional Therapy › Low fat liquids › High in protein and carbohydrates
  • 17.
  • 18.  Intra-corporeal Lithotripsy › Stones in the gallbladder or common bile duct may be fragmented by means of laser pulse technology  Extracorpeal Shockwave Lithotripsy › Non-invasive procedure uses repeated shock waves directed at the gallstones in the gallbladder or common bile duct to fragment the stones
  • 19.
  • 20.
  • 21.  Laparoscopic Cholecystectomy › Performed through a small incision or puncture made through the abdominal wall at the umbilicus  Cholecystectomy › Gall bladder is removed through an abdominal incision after the cystic duct and artery are ligated › A drain is placed close to the gall bladder if there is a bile leak, removed after 24 hours › Bile duct injury-serious complication  Choledochostomy › Making an incision in the common bile duct for removal of stones
  • 22.  Laparoscopic Cholecystectomy › Performed through a small incision or puncture made through the abdominal wall at the umbilicus
  • 23.  Cholecystectomy › Gall bladder is removed through an abdominal incision after the cystic duct and artery are ligated › A drain is placed close to the gall bladder if there is a bile leak, removed after 24 hours › Bile duct injury-serious complication
  • 24.  Choledochostomy › Making an incision in the common bile duct for removal of stones
  • 25.
  • 26.  Self- digestion of the pancreas by its own proteolytic enzymes, principally trypsin  Inflammation of the pancreas ranging from a relatively mild, self-limiting disorder to rapidly fatal, acute, hemorrhagic pancreatitis
  • 27.  Alcoholism  Cholecystitis  Surgery involving or near the pancreas
  • 28.  Abdominal tenderness with back pain  GI problems, such as nausea, vomiting, diarrhea and steatorrhea  Fever  Jaundice  Mental confusion  Flank or umbilical bruising  Hypotension  Signs of hypovolemia  Internal bleeding  Cullen’s Sign – bluish discoloration around the umbilicus  Turner’s Sign – discoloration lateral of the trunk or posteriorly
  • 29.
  • 30.  Elevated amylase  Lipase  Increase WBC Levels  Hypocalcemia
  • 31.  Administer prescribed medications, which include opioid or non-opioid analgesics, histamine receptor antagonist, PPI  Drug of Choice for pain: Morphine Sulfate  The client should avoid oral intake to inhibit pancreatic stimulation and secretion of pancreatic enzymes  Maintain fluid and electrolyte balance  Promote adequate nutrition
  • 32.
  • 33.  Progressive pancreatic inflammation resulting in permanent structural damage to pancreatic tissue  Results from repeated episodes of acute pancreatitis  More than half of chronic pancreatitis cases are associated with alcoholism  Long term alcohol consumption causes hypersecretion of protein in pancreatic secretions, resulting in protein plugs and calculi within the pancreatic ducts
  • 34.  Recurring attacks of severe upper abdominal and back pain  Weight loss  Steatorrhea Stools become frequent, frothy, and foul- smelling because of impaired fat digestion, which results in stools with a high fat content  Anorexia
  • 35.  Serum lipase and amylase elevated  WBC elevated  ERCP › Detects pancreatic calcification  Glucose tolerance test values are abnormal
  • 36.  Administer prescribed medications, which include pancreatic enzymes  Non-opioid pain medications, antacids, histamine receptor antagonist, & PPI  Provide symptomatic treatment focusing on relieve pain, promoting comfort, and treating new attacks  Emphasize then importance of avoiding alcohol, caffeine, and foods that tend to cause abdominal discomfort  Manage any endocrine insufficiency such as DM, by initiating dietary and insulin or oral hypoglycemic therapy
  • 37.  Pancreatic jejunostomy (Roux-en-Y) › Joining of the pancreatic duct to the jejunum › Allows drainage of the pancreatic duct to the jejunum  A Whipple resection (pancreaticoduodenectomy) › Can be carried out to relieve the pain of chronic pancreatitis
  • 38.  Pancreatic jejunostomy (Roux-en-Y) › Joining of the pancreatic duct to the jejunum › Allows drainage of the pancreatic duct to the jejunum
  • 39.  A Whipple resection (pancreaticoduodenectomy) › Can be carried out to relieve the pain of chronic pancreatitis