A phytosome is a complex of a natural active ingredient and a phospholipid - mostly lecithin. It is claimed that phytosome increases absorption of "conventional herbal extracts" or isolated active principles both topically as well as orally.

1. PHYTOSOM
E
Name – Tanaya Palit
Degree – B.Pharm ,M.Pharm
Designation – Assistant Professor

2. CONTENT
 Definition
 Advantages
 Difference between liposeome and phytosome
 Preparation
 Chemical and physical properties.
 Formulation
 Novel approaches for delivery
 Application of phytosome
 Conclusion
 Thank you

3. Phytosom
e
 Phytosomes are novel drug delivery system
containing hydrophilic bioactive
phytoconstituent of herbs surround and bound
by phospholipids.
 The term “phyto” means plant while “some”
means cell-like.
 Phytosomes are little cell like structure.

4. Advantages
 Enhanced absorption of herbal constituent.
 Better bioavailability
 Reduced dose
 Better stability profile
 Nutritional benefit
 Entrapment efficiency is high
 Enhanced permeation through skin

5. Difference between liposome
and phytosomes
Liposome Phytosome
 Here no biological bond
is formed the
phosphatidylcholine
molecules surround the
water soluble substances.
 Phytosomes involves
chemical bonds.
 Bioavailavility of
liposomes is less than
phytosomes.
 Phytosomes are much
better absorbed than
liposomes showing better
bioavailability

6. Preparation

7. Chemical and Physical
Properties
 Phytosomes are lipophilic substances with
definite melting point.
 Freely soluble in non-polar solvents and
aprotic solvents.
 moderately soluble in fats.
 Insoluble in water.
 When treated with water, phytosomes
assumes a micelles shape forming liposomal-
like structures.

8. Formulation of
Phytosome
Can be formulated both – 1) orally
2)topically
Tablet formation with
Phytosome complex
Hard gelatin capsule
formation With Phytosomes
complex
Soft gelatin capsule
Formation with phytosome
complex

9. NOVEL APPROACHES
FOR DELIVERY
Phytosome newly introduced patented technology
developed to incorporate standardized plant
extracts or water soluble phytoconstituents
into phospholipids to produce lipid compatible
molecular complexes they are also known as
Herbosome and delivered drugs at the targeted
area like liposome at it contains phospholipid.

10. Application of
Phytosome
Silymarin Phytosome
• Yanyu et al. prepared the silymarin phytosome and
studied the pharmacokinetics in rats.
• Most of the phytosomes are focused to Silybum
marianum which contains premier liver-protectant
flavonoids.
•The fruit of milk thistle plant contains flavonoids
known for hepato-protective effects.
• Silyamarin has been to show to have positive
effects in treating liver disease of various kinds like
hepatitis, cirrhosis,inflammation of bile duct.
Phytosomes of grape seed
•Grape seed phytosomes is composed of oligomeric
polyphenols of varying molecular size complexed with
phospholipids.
•The main properties of procyanidin flavonoids of
grape seed are in increase in total antioxidant capacity
and stimulation of physiological defenses of plasma.

11. Application of
Phytosome
Phytosomes of green tea
• Green tea leaves is characterized by presence of polyphenolic
compound epigallocatechin 3-o-gallate as the key component.
•These compounds are3 potent modulators of several biochemical
process linked to the breakdown of homeostatis in major chronic-
degenerative disease such as cancer and arthrosclerosis.
•Maiti et al. developed the phytosomes ofcurcumin (flavonoid
from turmeric, Curcuma longa linn) and naringenin (flavonoid
from grape, Vitis vinifera).
• phytosome of naringenin produced better antioxidant activity
than the free compound with a prolonged duration of action.
Phytosomes of curcumin
•Maiti et al. developed the quercetinphospholipid phytosomal
complex by a simple and reproducible method and also showedthat
the formulation exerted better therapeutic efficacy as compared to
the non-phytosomalconventional preparation in rat liver injury
induced by carbon tetrachloride
Quercetin-phospholipid phytosomal complex

12. Conclusio
n
 The phytosomes is novel dosage
from and which is used for the
preparations of final product like
tablet, capsule, gel, suspension.
 Phytosomes is used to increase
the solubility as well as
permeability of the
phytoconstituents present in part

13. Reference
 PHYTOSOME: A NOVEL REVOLUTION IN HERBAL DRUGS Joseph A.
Kareparamban*, Pravin H Nikam, Aruna P Jadhav and Vilasrao J
Kadam Department of Quality Assurance,Bharati Vidyapeeth’s College of
Pharmacy, Sector-8 C.B.D., Belapur, Navi Mumbai, Maharashtra
 Phytosome: A Brief Overview Sanjay Saha*, Anupam Sarma, Pranjal
Saikia, Tapash Chakrabarty Girijananda Chowdhury Institute of
Pharmaceutical Science, Department of Pharmaceutics, Azara, Assam
(India) Guwahati- 781017,
 Phytosomes is a Novel Drug Delivery System based herbal
formulation: An Review Devender Sharma1*, Ankita A. Bhujbale2 1Hi –
Tech College of pharmacy, Chandrapur, Maharashtra, India 2Sinhgad
College of Pharmacy, Vadgaon, Pune, Maharashtra, India