Adeptia, Inc. - Lonza Whitepaper

Leading the
Revolution
Integration
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Whitepaper
SMART INFORMATION:
The Lonza Business Analytics Story
Published: August 2013
© 2013,Adeptia,Inc.and Lonza

Leading the
Revolution
Integration
Executive Summary
Aleadingsuppliertothelifesciencesindustries,LonzaAG,byvirtueofitssize,globalnatureandthe
complexitiesofitsbusinesses,overtheyearshasgeneratedvastamountsofdata,whichresidesacross
GlobalBusinessSystemsanddisparatedatasources. Asaresult,in2011Lonzacommittedtocreateand
deployaBusinessAnalyticsGlobalProgram–aprogramthatwouldmakeuseofallitsdataandturnitinto
informationtosupportdecision-makingandprocessimprovements. Theprogramcatch-phrasewas:
“Wearerichindatabutverypoorininformation.”
TheaimoftheLonzaGlobalAnalyticsProgramistostandardizethecorporation’sapproachtoobtainingits
vastquantitiesofoperationaldatainuseacrossallofLonza’ssitestotransformthisdataintospecific,relevant
andtimelyinformation. Theprogramalsowasconceivedtoaddressdatausageproblemsandtheirbusiness
impactbyutilizingnon-disruptivestrategiesfor
deployingBusinessAnalyticsProcess,Methods
andSoftwaretools.
The Program’s intended objectives also
included how to:
• Addressbottlenecksandlatenciesindataprocessingcausedbyburgeoningdatasourcesand
shortenedoperationaltimeframeswhiledeliveringBusinessProcessInsightInformationthatleads
toprocessimprovements,
• ProductivitygainsthroughthedeploymentofSelf-ServiceBusinessAnalytics,and
• EnablingtheDecision-Makersatalllevelstocreatevalueanddelivercostsavings
Inshort,thechallengewashowtoattainamarriageof“SMARTInformation”with“completeDataintegration”
throughitsnewBusinessAnalyticsGlobalProgram.
PeterJ.Mueller,manageroftheLonzaBusinessAnalyticsGlobalProgramdetailshowAdeptiaishelping
tosolvetheseissuesforLonza. Lonza’snewGlobalDataIntegrationModelutilizingAdeptia’sEnterprise
BusinessIntegrationManagementSuite(EBIMS)createsaglobaldeliveryvehicleforLonza–adata
integrationmodelformaintainingdataqualityandintegritythroughan“OperationProcessDataAppliance
Architecture,”orwhatMuellercalls “TheCompleteEnterpriseServiceBus.”
Adeptia’sEBIMSSuite,Muellerfurtherexplains,nowallowsforanaccurate,lean,responsive,transparent,
meaningfulandflexibleBusinessAnalyticsmodelforLonza. ItfacilitatesLonza’sabilitytobuilddata
transactions,automatethedatatransactionsandintegratethedatatransactions,continuallyoptimizingthem
in-process(notaftercompletion). WithEBIMS,notesMueller,Lonzaalsoisabletoanalyzeandimprovethe
performanceofitsdatatransactionsandprovidereal-timepublishingofrelevantandtimelyinformation–
keyadvantagesinspeed-to-marketandmaintainingLonza’sleadershipamongitscompetitors.
“We are rich in data…but
very poor in information.”

Leading the
Revolution
Integration
White Paper
Table of Contents
I. About Lonza AG
II. “SMART Information”for Complete Integration
III. Retooling the Organizational Mindset
IV. New Responsibilities for the Business Users
V. The Approach to Data Integration
VI. Data Integration and“The Standard ofThree”
VII. Three Data Highways
VIII. Data Integration as Global DeliveryVehicle
IX. Global Standards for Data Usage at Lonza
X. EBIMS the Lonza Business, 2014 and Beyond
• Building the DataTransactions
• Automating to Improve DataTransactions
• Integrating DataTransactions
XI. AddedValue of the Adeptia EBIMS Suite
• Non-Invasive Balance
•Transparency that Increases Knowledge
• Support for Integration Lean Initiatives
XII. EBIMS Suite the Strategic Advantage
XIII. Conclusion
XIV. About the BA Program Manager

© 2013,Adeptia,Inc.and Lonza 4
I. About Lonza AG
Swiss-based Lonza AG is one of the worlds’leading suppliers to the healthcare,pharmaceutical and
life science industries,with products and services that span its customers’needs from research to
final product manufacture.Headquartered in Basel,the company leads in the production and support
of active pharmaceutical ingredients,both chemical and biological,and in microbial ingredients.Its
Specialty Ingredients Business Segment division provides innovative,chemistry-based solutions that
destroy and selectively inhibit the growth of harmful microorganisms.
Lonza furnishes state-of-the-art products,services and research to seven
different markets:BioResearch,Pharma Biotech,Nutrition,Microbial Control,
Agriculture,Materials Science and Personal Care.
In 2012,the company reported sales of CHF 3.925billion.
II. “SMART Information”for Complete
Integration
As a leading supplier to the life sciences industries,Lonza AG over the years has generated vast
amounts of data residing across disparate business systems and sources.As a result,in 2011 Lonza
committed to create and deploy a Business Analytics Global Program – a program that would make
use of all its data and turn it into useful analytics.The program catch-phrase was:“We are rich in data
but very poor in information.”
The Lonza Global Analytics Program aim was to standardize the corporation’s approach to obtaining
vast quantities of operational data resident across Lonza’s disparate business systems and to transform
this data into specific,relevant and timely information.The program also sought to address data usage
problems and their business impact by utilizing non-disruptive strategies for deploying Business
Analytics Software.
In short,the challenge was to attain“SMARTinformation”and marry itwith“completeData
integration” through its new Business Analytics Program,or how to:
• Manage the integration of data into business processes by the intendeduseofthedata,
not by its business system
• Makesmarter,moreefficientdecisionsthatwouldresultinfastertimetovalueand
delivery,and
• Create specific,meaningful,accurate,relevant and timely information
“Our responsibility is to turn
users into self-sufficient
data consumers…
and help them better manage and define
their data.We instruct them to integrate
the data by intended use within the
required business processes.”

III. Retooling the Organizational Mindset
As manager of the new Lonza Business Analytics Global Program,Mueller understood that it was
crucial for Lonza to retool its organizational mindset in addition to simply implementing a new data
integration architecture.The mindset shift required moving away from the established Lonza business
model of“buy the business system to meet the need,”to one characterized by“rent our tools and
techniques for the exceptions.”
This change in thinking meant that the model should now focus on those elements that the business
systems couldnot provide,in order to make better,more effective use of the data.This mindset shift,
in turn,translated into a much larger and extremely significant mindset shift —
now the company’s IT Organization was asked to take on a supportrole to the
Business Analytics Global Program,rather than being the owner and driver of the
Business Analytics Global Program.With this change,the BA Program reported
directly into Operations,with Lonza’s Global IT Organization acting as a support
mechanism for this program.
With IT now in a support role,a new approach to data ownership emerged.With
the data put directly into Operations,data became in essence“operational data.
IV. New Responsibilities for the Business Users
With the new approach,new responsibilities toward the user community now appeared for the
business analytics team.These involved:
•Teaching users the appropriate techniques
• Instructing users on the proper use of tools and
•Transforming users into self-sufficient data consumers and information publishers
Ourresponsibilitytotheusercommunitynowhasbecometoteach,instructandtransformthedatausers
intoself-sufficientdataconsumers.WeidentifykeyindividualswithinOperationsasdataownersand
helpthembettermanageanddefinetheirdata.Weinstructthemtointegratethedatabyintendeduse
withintherequiredbusinessprocesses.Usersaretold:“Lookatthebusinessprocessesyouhave,definethe
dataatits‘pointofuse’withintheprocessandthendefinethedatabasedonitsusewithintheprocess.”
Attainingthisnewmindsetandattitudetowardthedataisimperative.
By integrating Adeptia EBIMS, Lonza has effectively begun transferring ownership of the data from
IT and putting it into Operations — with one final mindset change: Now dataisseenasraw
materialused to build the analytics and to build the information.Now,controlofthequalityof
thedataoccursatitssource.This change initiates a new role for IT,that of data custodians.Data
custodians are responsible for making regional and global systems available 24/7,365days a year,
so that the organization can have access to the data that resides in its business systems.IT now must
realize that thedataisnotthetrueasset.Thetrueassetistheinformationandanalyticsthatyou
generateusingthedata.
The driver behind Lonza’s Business Analytics Global Program has become the more efficient use of the
data — that is,to use the data to actually drive value into the business and improve delivery,internally
and to customers.The goal that has emerged:CreateDeliverSmartInformation.
“With IT now in a support
role, a new approach to data
ownership emerged. With the
data put directly into Operations, data
became in essence operational data.”

The corporation now can manage the integration of data into business processes by the intended use
of the data,not by the business system from which the data derives.With SMART Information,the
Business Analytics Global Program and users can support the Decision-Making Process at all levels
With the EBIMS Suite the Lonza Business Analytics Global Program equips users with a set of tools
and techniques that helps them:
• Make smarter,more efficient decisions
• Achieve faster timeto valueanddelivery
• Create specific,meaningful,accurate,relevant and timely information
V. The Approach to Data Integration
The change in the organizational mindset is only one feature that necessarily characterizes the Lonza
Business Analytics Global Program.The BA Program also works to achieve“complete integration,”which
simply means integrating the data into every aspect of the Lonza business where it adds value and has
extreme relevance.Reaching this goal of“smart Information”for this complete integration requires a
specific framework and set of tools and techniques labeled“The Standard ofThree.”
VI. Data Integration and“The Standard ofThree”
“The Standard ofThree”involves three core components (see diagram 1):
• Three primary roles responsibilities within the BA Program – data architect,
business systems analyst and systems architect
• Three primary data integration views – the data governance view,the user view
and the blueprint view
• Three primary data governance views – master data management,data quality
and data integration
Diagram 1

Diagram 1 illustrates this approach to data integration contained in the BA Program framework.To
achieve complete integration for smart information,Lonza will have to employ all of these standards.
The userview includes the tools and techniques that are simple,understandable and easily taught to
the user community as a whole.That responsibility falls to the businesssystemsanalyst who needs to
connect and communicate clearly with customers – internal and external – properly training them in
the new tools and techniques of the BA Program.
The blueprintview involves the behind-the-scenes technical mechanics of how
data is moved from point A to point B.It is the responsibility of the
systemsarchitect.
The datagovernanceview,presently scheduled for completion in 2014,and will
become the responsibility of the dataarchitect entails Lonza leveraging the now-
available industry data governance model rather than creating an entirely new
industry model particular to the BA Program.This data governance breaks down
into three primary data governance views – masterdatamanagement,data
quality and dataintegration.
The“Standard ofThree”,as Diagram 1 demonstrates,is a matrixed approach where
responsibilities and activities are as simple as possible to avoid any one role“tripping over another”and
to prevent possible wasteful redundancies being introduced into the Lonza business as a whole.
VII. Three Data Highways
In tandem with this“Standard ofThree”framework,Lonza next had to identify how its data travels.
Utilizing EBIMS,there are onlythreeprimarypathsforthedatatotravel so that it keeps moving in
the straightforward and streamlined manner (see diagram 2).
The first path is called the systemsintegrationpath because it ties systems together at the data level.
The second data highway is unique to data generated by Lonza as a global life-sciences company.
Lonza,like many companies in its sector,needs a distinct global statistical platform to span many
caches of data — called bio-informatics data — to be stored and easily accessible for the advanced
scientific analysis involved in bio-informatics.While most statistical platforms cannot extract data
as required by the Lonza global infomatics group from more than one source,theso-called(bio)
informaticspath that EBIMS enables can be utilized for just this purpose.
The next path,the BA publishingpath,is simple:it provides Lonza with the ability to take the data and
turn it into information — whether from global sources or from shared drives and resources,including
outlying Excel files held by some customers at Lonza.The publishing path can access all this data,
turning it into useful,published information.
In fact,simplicity is the underlying premise of the BA Program that utilizes EBIMS.The Program
establishes three roads for the data to travel,three positions,and three different views – keeping
them aligned throughout the process.Adeptia EBIMS is the critical piece to create and maintain these
data highways.

“IT is taking on a support
role to the Business Analytics
Global Program, rather than
being the driver…with IT now in
a support role, a new approach to data
ownership emerged. With the data put
directly into Operations, data became
in essence“Operational data.”

Viii. Data integration as Lonza’s Global DeliveryVehicle
With the roads established,however,we determined that Lonza still needed to have some sort of
formal structure indicating:
• How data would be loaded (via a transport vehicle or “truck”)
• How the data would be moved
• In what event the “truck” would stop (such points being called “enterprise service spots”) and
• How the complete operational processes were to be delineated
This Global Delivery Vehicle and the formal operational process are respectively the EnterpriseService
Bus and the OperationalProcessDataApplianceArchitecture(OPDA). See Diagram 3.
Diagram 3
Diagram 2
8

IX. Global Standards for Data Usage at Lonza
With the highways identified,the vehicles at the ready to move the data and the process in place to
load the vehicles,Lonza next established global standards to govern data usage.
Adeptia played an indispensible role during this phase,allowing Lonza to achieve its goal of setting
up firm data usage standards.As shown in the matrix in Diagram 4,the key to standards development
was to make sure that Lonza had the integration function positioned on the verticals of this formal
matrix,with data movement shown on the horizontals of the matrix.Note that what these vertical and
horizontal functions developed through EBIMS guaranteed was that nothing in program process was
affecting the quality and integrity of the data as it was moved.It also assured that the right data was
picked up and delivered to the right person at the right time.

X. EBIMS the Lonza Business, 2014 and Beyond
Today,Lonzahasathree-yearstrategyinplacetocompletetheintegrationofAdeptiaEBIMSthroughout
theLonzabusiness.Wecanreportthattheprogramiswellunderwaywithgreatsuccess(seeDiagram5).
Adeptia’s first step for Lonza was to buildthesimpledatatransaction (see Diagram 5.a) to acclimate
Lonza AG to the solution and then to integrate the solution into the Lonza business via the new Lonza
Global BA Program.Being able to build standard data transactions allowed Lonza to proceed with step
two,which was toautomatethedatatransactions (see Diagram 5.b).Lonza here utilized the Adeptia
Enterprise Service Bus and the Adeptia Service-Oriented Architecture — key elements behind Adeptia
EBIMS — to achieve the improved data transactions and to define the new Lonza“rules of the road.”
Diagram 4

Once the primary data transactions were established satisfactorily and the key improvements were
accomplished,the next step in EBIMS integration was to examine Lonza’s data governance initiative
(see Diagram 5.c).Through the Adeptia EBIMS solution,Lonza effectively and efficiently examined the
process of profiling its data,thereby establishing data quality attributes and measuring the quality
and integrity of the data.
In 2014,EBIMS will be utilized and integrated further.Lonza will integrate everything it possibly can
into the business pertaining to data,with great transparency to the user (see Diagram 5.d).
XI. AddedValue of the Adeptia EBIMS Suite
Integrating EBIMS into the Lonza BA Program has generated several additional benefits.EBIMS allows
for what Lonza calls a“Indiscernible,orUnseenBalance.” Quite simply,this means that Adeptia
affords Lonza the ability to centralize and manage the way data is moved within the company in a
controlled behind-the-scenes manner.In the data quality initiative,EBIMS adds value by allowing
Lonza to evaluate and examine existing stored data and to examine newly acquired data along
with existing data.
One of the most important current and future benefits gained from EBIMS — especially as the BA
Program moves into its 2014phase — is the transparency it affords users. Most users don’t concern
themselves with transactions,normalizing data relations,sequencing,and all the technical aspects
and terminology.Given the nature and configurability of the Adeptia solution,users really can“see for
themselves”what is happening“behind the scenes,”without concerning themselves with the
technical aspects.
One final additional benefit of the EBIMS tool is what Lonza calls“the Matter of Knowledge,”or Lonza’s
pursuit for insight regarding how it learns and makes informed decisions throughout data integration.
“EBIMS allows for what Lonza calls a
“Non-Invasive Balance.” Quite simply,
this means that…
Adeptia affords Lonza the
ability to centralize and
manage the way data is
moved within the company
in a controlled manner.”
Diagram 5
(a)
(b)
(c)
(d)

Adeptia EBIMS supports Lonza throughout its data integration process and fits nicely with other
integrationandleaninitiativesalready in place.The utilization of EBIMS enhances Lonza’s s ability to
hone the“plan-do-check-act”process of data integration,strengthening the organization’s pursuit of
ways to learn and improve,thereby augmenting Lonza’s own lean initiative.
XII. EBIMS Suite the Strategic Advantage
A final and significant benefit of EBIMS is the competitive edge it brings to Lonza.
Pharmaceutical companies often complain that their contract manufacturers fail to provide data to
them when they need it,in the format they need it and at the exact time they need it.With so many
data integration tools on the market and with today’s systems often thrown together at the electronic
and data levels,some pharmaceutical companies are actually becoming static in their data integration
capabilities.Since contract manufacturing is a very large portion of the Lonza business,
the ability to provide their customers with these MFT B2B data transactions on demand,
in real-time and in formats they require affords a real strategic advantage to Lonza.In
fact,at present,there are no CMOs outtherethatarecommittedtoputtingmoneyand
resourcesbehinddeliveringthistypeofservicetothepharmaceuticalcompanies.
Since Lonza,however,already has a BA Program with the Adeptia solution,it will be able to
deliver those MFT B2B transactions with very little effort.These transactions may require
a bit more effort on the part of pharmaceutical companies,but with EBIMS,Lonza will be
the firstcontractmanufacturerinthemarketplaceabletoprovidethesetypesof“on-
boarding”B2Btransactionsasaservicetoitscustomers.It is highly strategic for Lonza
to position itself where it can say to customers:“We are ready to deliver the data,now you only need
to make sure you are ready to receive it.” Lonza’s implementation of EBIMS into its data integration
model constitutes just such a strategic and competitive breakthrough for the company.
XIII. Conclusion
In 2011,realizing a need to make better use of its data,Lonza committed to the creation of a forward-
looking Business Analytics Global Program.The company decided to look outside for individuals who
could define and deploy the program.Once this phase was accomplished,Lonza identified the need for
a centralized data integration solution for its Business Analytics Global Program.
After a strenuous vendor assessment process,Lonza selected the Adeptia EBIMS platform.EBIMS
applied to the Lonza Business Analytics Data Integration Model now enables Lonza to achieve cost-
effective and centralized ways to move its data in a controlled manner,to be thorough in the handling
of both new and existing data,to permit transparency toward users,to be correct as data is moved and
to be extremely data efficient.
As the three-year strategy to integrate EBIMS into the Lonza BA Program moves forward,Lonza
foresees continued success in achieving“smart information”for the“complete Integration”of data
across the company’s diverse business portfolio.
“Data is seen as raw material to be
used to build the analytics and to build
the information…data is not the true
asset…the true asset is the
information and analytics
that you generate using
the data.

XIV. About the BA Program Manager
Peter J.Mueller,an internationally known information technology expert and
software engineer, has served since early 2011 with Lonza PharmaBiotech as
Global Manager of its Business Analytics Global Program and as Program Lead
of its Global Data Governance initiative.
Mueller has more than 20 years experience managing regional,national and global
projects related to effective Process Improvement,New Product Development,
Project Management,Software Quality Assurance,Software Engineering andTeam Leadership for
organizations ranging from Bausch Lomb and Eastman Kodak Company to Xerox Corporation and a
NewYork State Health Maintenance Organization.
He most recently has created and deployed the Lonza Business Analytics Global Program Team
to achieve a standardized global approach for Lonza using non-disruptive strategies for deploying
Business Analytics SoftwareTools.He also is lending his expertise to providing Lonza with a new
Centralized Global Data Governance Program and Data IntegrationTool to govern and manage all data
generated by the firm’s disparate business systems and software platforms.
Mueller has served in key IT management,engineering and process improvement roles for companies
in the healthcare and medical device fields and in the business imaging and digital printing products
sectors.He also has applied his mastery of Process Improvement,Project Management,Software
Quality Assurance,Software Engineering/Testing,Due Diligence and Employee Management/
Development across a range of other businesses and market sectors.
In addition to many technology credentials,he holds numerous security and product-development
standards credentials,including HIPAA and Sarbanes-Oxley.His Process Management and Information
Lifecycle Management Standards knowledge includes:SOA,BPM,EAI,MOF,RUP andTOGAF.
Peter received his Bachelor of Science in Business Administration (Management Information Systems
Managerial Decision Sciences) from the University of Dayton.

Adeptia, Inc. - Lonza Whitepaper

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