This document describes the case study of David Reimer, who was born as Bruce Reimer and underwent a failed circumcision as an infant that burned off his penis. Dr. John Money recommended a sex change operation and that Bruce be raised as a girl named Brenda. However, Brenda struggled with living as a girl and was bullied in school. At age 14, Brenda's parents told her the truth and Brenda transitioned back to living as a boy named David. David later married and had children but committed suicide in 2004 due to the psychological trauma of his experiences. The case highlighted ethical concerns about Dr. Money's agenda to prove that gender is determined by nurture rather than nature.