Autologous stem cells and transplantation process

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Autologous Adult Stem cells
and Transplantion Process

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Website : www.stemgenn.com | Email : Contact@stemgenn.com | Phone : +91 9910596674
Autologous Adult Stem cells and Transplantion Process
Autologous or Adult stem cells (ASCs) are the "multipotent"
cells which are found throughout the body.
These cells do not involve embryos and is less controversial as
compared to pluripotent cells.
Their ability to differentiate is more limited than pluripotent
cells but is vast nonetheless.
The NIH’s site provide a list of around 4500 ASC trials as
compared with 27 for embryonic stem cells and 21 for induced
pluripotent stem cells.

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Recent announcements of new stem cell treatments usually
involve ASCs, such as there was news that a toddler born
without a trachea received a new one made from her own adult
stem cells. Due to which now all the attention of researchers
has been grabbed by ASC’s both here in India and abroad.
Today’s, Physicians routinely offer treatments involving ASC's
transplantation to their patients which can be performed in
their clinics.
Autologous adult stem cells, used to treat a variety of
conditions and are harvested from the patient, processed, and
returned to the same patient.

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Treatable diseases using autologous stem cells
The diseases which are being treated nowadays using autologous stem
cells mostly related to damage or destruction of bone marrow which
includes diseases such as non-Hodgkin's lymphoma and Hodgkin's
lymphoma, leukemia, multiple myeloma, and aplastic anemia.
Restoration of bone marrow is being done that has been damaged by
total body radiation and high doses of chemotherapy used for cancer
treatment.
Apart from above diseases, these cells have also been used for the
treatment of diabetes, Parkinson's disease, sickle cell disease,
and thalassemia.

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Source of stem cells and the process of transplantation
The source of stem cells used in transplants can be :
Autologous stem cells - Patient receives stem cells from his own
blood.
Allogeneic stem cells - Patient receives stem cells from a donor.
*The donor used in an allogeneic stem cell transplant can be the
patient's identical twin, sibling, family member or an unrelated donor.

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For Autologous transplants physicians usually collect the stem cells from
the peripheral blood rather than the bone marrow cells.
The growth factor G-CSF may be used to stimulate the growth of new stem
cells so they spill over into the blood.
*G-CSF is a protein that is produced naturally in the body.
The blood is removed from a vein and passed through a machine that
separates the stem cells. The machine then returns the remaining blood
through a needle in the person's arm or through a central venous catheter.
This way of collecting stem cells is called apheresis.
In adults, most autologous transplants use stem cells from blood. In a
child, the decision whether to use cells from the bone marrow or the blood
depends on the size of the child.

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Advantages of adult stem cells over autologous transplantations
In an autologous stem cell transplant procedure, the body recognizes the self- cells and
does not lead to a condition known as Graft-versus-Host Disease (GVHD).
Treatment process does not require immunosuppressant's and histocompatibility
matching.
The process of finding a donor for stem cell treatment is not required as the stem cells
are taken from the patient itself.
Autologous blood is readily available, and immune reconstitution is more rapid than
after allogeneic.
Autologous transplants are relatively safe procedures, with low rates of complications
and infections compared with other type of transplants.
Treatment related mortality rate is 2% to 3% in patients in most of the studies.

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Disadvantages of adult stem cells over autologous transplantations
Apart from having a lot of benefits as compared to other types of
transplantations, Autologous stem cells have some disadvantages as well:
Stem cells after transplantation may get infected with tumor cells and
contribute to relapse of the tumor condition.
Autologous transplants cannot be used for genetic or acquired diseases in
which the hematopoietic cells are injured or defective.
Prior treatment with certain chemotherapy drugs or with radiation therapy
to the spine or pelvis may reduce the number of stem cells that can be
collected for an autologous transplant in certain cases.
Possible marrow injury leading to myelodysplasia (Either from prior
chemotherapy or transplant regimen).

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Stemgenn Therapeutics is one of the centre where stem
cells are being used for the treatment of various life
threatening diseases.
It is the leading Cell therapy & Regenerative medicine
services company that supports the development and
commercialization of cellular therapies and stem cell
research.
Stemgenn provides cGMP-compliant cell manufacturing
and consulting services that address regulatory, financial,
technical, process, training and quality system strategies.
Services include a full spectrum of support and consulting
related to process and product development, validation,
due diligence evaluations, tissue collection, processing, and
storage, product manufacturing, distribution and
transportation.

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Why StemGenn Therapeutics?
• As Stem cell have inherent properties to self renew and
differentiation into other cell types. They are multi potent
and found within our body.
• No side effects: as it's found in patient's own tissues or
blood, chances of rejection and infection is negligible.
• World class clinicians and experts from Regenerative
Medicine.
• Cost Effectiveness: autologous stem cell transplant is very
much affordable.
• Non- Surgical Procedure & convenient.
• Proven Results.

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For more detail:
Email: contact@stemgenn.com
Mob : +91 9811011690
W: StemGenn.com

Autologous stem cells and transplantation process

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