Presentation by Dr Steffi Friedrichs, entitled: Nanotechnology at the Crossroads of Converging Technologies: Unveiling the Future of Innovation presented at the meeting on 'Open Innovation for Materials Modelling, Design and Manufacturing', 19th – 20th October 2023, at the Luxembourg Institute of Science & Technology.

1. Nanotechnology at the Crossroads of
Converging Technologies:
Unveiling the Future of Innovation
Open Innovation for Materials Modelling, Design and Manufacturing
19th – 20th October 2023
– Luxembourg Institute of Science & Technology –

2. Today’s Demands on Chemical & Material Innovations
2
Nanotechnology at the Crossroads of Converging Technologies: Unveiling the Future of Innovation
OIP-2023.eu - 19th October 2023
• Sustainability
• Circularity
• Resilience
… and (some of) the policies that substantiate them:
• Green Deal (2019)
• EU Plastics Strategy (2018)
• New Circular Economy Action Plan (2020)
• Critical Raw Materials Act (2022)
• Safe & Sustainable by Design Framework (2022)
• European Chips Act (2023)
[source: Outline of the Circular Economy, PBL – Netherlands Environmental Assessment Agency, 2019]

3. Consequences for Safety & Sustainability Assessments
3
Nanotechnology at the Crossroads of Converging Technologies: Unveiling the Future of Innovation
OIP-2023.eu - 19th October 2023
… guided by the ‘Safe & Sustainable by Design’ Framework
[source: Safe and Sustainable by Design chemicals and materials, JRC, 2022]

4. [source: Safe and Sustainable by Design chemicals and materials, JRC, 2022]
Safety Aspects in
the SSbD Framework
4
Nanotechnology at the Crossroads of Converging Technologies: Unveiling the Future of Innovation
OIP-2023.eu - 19th October 2023
… and all of this for materials
… and (sometimes) without reliable
harmonised test guidelines and/or
standards.
… this is where and why
‘nanomaterials’ safety research enters the stage …

5. 5
Nanotechnology at the Crossroads of Converging Technologies: Unveiling the Future of Innovation
OIP-2023.eu - 19th October 2023
Harmonisation & Standardisation of (Nano)Materials
– A brief History
‘classic’ Standardisation of Nanotechnology & Nanomaterials
ISO/TC229 Nanotechnologies
(2005)
CEN/TC 352 Nanotechnologies
(2005)
ASTM International
Committee E56 on
Nanotechnology (2005)
IEC/TC 113 Nanotechnologies
for electrotechnical products
and systems (2006)
Regulatory relevance of Nanomaterials Safety
OECD’s Working Party on
Manufactured Nanomaterials
(2007)
NANoREG (2013 – 2017)
PROSAFE (2015 – 2017)
NANoREG II (2015 – 2019)
Safe & Sustainable by
Design (SSbD)
PARC (2022 – 2029)
SSbD Framework (by JRC)
(2022)
MACRAMÉ (2022 – 2025)
§

6. 6
Nanotechnology at the Crossroads of Converging Technologies: Unveiling the Future of Innovation
OIP-2023.eu - 19th October 2023
Harmonisation & Standardisation of Nanomaterials
Terminology
Achieved 18
On-going 7
Measurement
Achieved 8
On-going 6
Characterisation
Graphene
Achieved 13
On-going 8
ISO
Exposure and
Risk
Achieved 23
On-going 11
Characterisation
(Other)
Achieved 27
On-going 2
Performance
Evaluation
Achieved 3
Ongoing 3
Terminology
Achieved 7
On-going 5
Measurement
Achieved 5
On-going -
Exposure and
Risk
Achieved 19
On-going 11
Characterisation
(Other)
Achieved 1
On-going 3
Other
Achieved 4
CEN
Physico-chemical
Characterisation
Achieved 5
On-going 5
Human
Toxicology
Achieved 5
On-going 5
OECD
Environmental
Fate
Achieved 1
On-going 3
Environmetal
Toxicology
Achieved 1
On-going 4
End of Life
Achieved 1
Ongoing 1
215 Standards! But we still have gaps

7. 7
Nanotechnology at the Crossroads of Converging Technologies: Unveiling the Future of Innovation
OIP-2023.eu - 19th October 2023
(Nano)Materials Standardisation Gaps
Ecotox
Phys-
Chem
Data
Environ-
mental
Fate
In vitro
In vivo
Dispersion in test samples
Detection in complex media
Guidelines for explosivity
Methods for oxidising properties
Reference materials for dustiness
Stability in relevant media
Dosimetry
Inflammation
Skin irritation/corrosion
Absorption Oral/dermal
In vitro Cell toxicity
Genotoxicity – comet assay
Reactivity
Reproductive toxicity
Skin sensitisation.
Phototoxicity
Toxicity by dermal route
Phototoxicity
Pre-natal toxicity
Reproductive toxicity
Immunotoxicity
Neurotoxicity
Endocrine disruption
Invertebrate toxicity
Plants and algae
Microbial toxicity
Toxicity in birds or mammals
(A)biotic degradation
Transport in air
Methods for ultrafine particles
Transport in water
Bioaccumulation
Biomagnification
Transport in soils
Data Description
Data Curation
Data Quality
FAIR Data
Publication
:

8. The MACRAMÉ project has received funding from the European Union’s Horizon
Europe Research and Innovation programme under grant agreement No. 101092686.

9. MACRAMÉ’s central Objectives
9
• detect, characterise and quantify Advanced Materials (AdMas) during handling
and processing along the product life-cycle,
• assess potential impacts on (human) health and the environment in intended or
unintended exposure situations (i.e. ‘Exposure Points’) in the product value-
chain,
• advance the wide-spread applicability of the developed test and characterisation
methods, by demonstrating their effectiveness and efficiency in the context of
existing, market-relevant industrial AdMas containing products, and
• prepare and initiate standardisation, harmonisation and technological &
regulatory validation of test- and characterisation-methods.
Nanotechnology at the Crossroads of Converging Technologies: Unveiling the Future of Innovation
OIP-2023.eu - 19th October 2023

10. The MACRAMÉ R&I Approach
10
Illustration of the MACRAMÉ R&I
Approach (AdMa@CMs: Advanced
Materials in complex matrices; CF:
Characterisation Factor; GRM:
graphene-related material; IATA:
integrated approaches to testing and
assessment; LCA: Life-Cycle
Assessment; LCC: Life-Cycle-Costing;
MFA: Material-Flow Analysis; RA:
Risk-Assessment; SSbD: Safe-&-
Sustainable-by-Design).
Nanotechnology at the Crossroads of Converging Technologies: Unveiling the Future of Innovation
OIP-2023.eu - 19th October 2023

11. market-relevant industrial MACRAMÉ Use-Cases:
• Graphene oxide (GO) flakes in drinking-water filters;
• Few-layer graphene (FLG) in battery management systems (BMS);
• Graphene-related materials (GRM) in car polish consumer sprays;
• Carbon nanotubes (i.e. CNTs) in car-seats; and
• Poly lactic-co-glycolic acid (PLGA) for inhalable antibiotics.
… selected to conduct:
• SSbD: Safe-&-Sustainable-by-Design
• LCA: Life-Cycle Assessment
• LCC: Life-Cycle-Costing
• MFA: Material-Flow Analysis
• RA: Risk-Assessment
… building on real, market-relevant Products
11
5
Nanotechnology at the Crossroads of Converging Technologies: Unveiling the Future of Innovation
OIP-2023.eu - 19th October 2023

12. The MACRAMÉ’s Foundations
– Analyses, Assessments & Validations in industrial Value-Chains –
12
‘Wimmelbild’ (engl. ‘teeming picture’)
Pieter Bruegel d. Ä . (source:
© KHM-Museumsverband)
Nanotechnology at the Crossroads of Converging Technologies: Unveiling the Future of Innovation
OIP-2023.eu - 19th October 2023

13. The MACRAMÉ’s Foundations
– Analyses, Assessments & Validations in industrial Value-Chains –
13
Nanotechnology at the Crossroads of Converging Technologies: Unveiling the Future of Innovation
OIP-2023.eu - 19th October 2023

14. The MACRAMÉ’s Foundations
– Analyses, Assessments & Validations in industrial Value-Chains –
14
Terminology:
• AdMa = Advanced Material
• CM = Complex Matrix
• EM = Environmental Matrix
• BM = Biological Matrix
• CPM = Complex Product Matrix
• EoL = End-of-Life
• AdMa@CMs
• AdMa@EM
• AdMa@BM
• AdMa@EoL(CPM)
• AdMa@EoL(CPM)@EM
Nanotechnology at the Crossroads of Converging Technologies: Unveiling the Future of Innovation
OIP-2023.eu - 19th October 2023

15. The MACRAMÉ R&I Approach
15
Illustration of the MACRAMÉ R&I
Approach (AdMa@CMs: Advanced
Materials in complex matrices; CF:
Characterisation Factor; GRM:
graphene-related material; IATA:
integrated approaches to testing and
assessment; LCA: Life-Cycle
Assessment; LCC: Life-Cycle-Costing;
MFA: Material-Flow Analysis; RA:
Risk-Assessment; SSbD: Safe-&-
Sustainable-by-Design).
… Exposure Points …
Nanotechnology at the Crossroads of Converging Technologies: Unveiling the Future of Innovation
OIP-2023.eu - 19th October 2023

16. The MACRAMÉ’s Foundations
– Analyses, Assessments & Validations in industrial Value-Chains –
16
Legend:
• AdMa = Advanced
Material
• CM = Complex Matrix
o EM = Environmental
Matrix
o BM = Biological Matrix
o CPM = Complex
Product Matrix
• EoL = End-of-Life
• AdMa@CMs
o AdMa@EM
o AdMa@BM
o AdMa@EoL(CPM)
o AdMa@EoL(CPM)@EM
Nanotechnology at the Crossroads of Converging Technologies: Unveiling the Future of Innovation
OIP-2023.eu - 19th October 2023

17. Meeting Announcements
17
1. Harmonisation & Standardisation Workshop:
22nd – 23rd November 2023, ONLINE
2. 1st MACRAMÉ Regulatory Risk Assessors’ Summit:
27th – 28th November 2023, Berlin
3. ‘Materials Week 2024’:
17th – 21st June 2024, Limassol, Cyprus
*** subscribe to the MACRAMÉ Newsletter***
Nanotechnology at the Crossroads of Converging Technologies: Unveiling the Future of Innovation
OIP-2023.eu - 19th October 2023

18. The MACRAMÉ project has received funding from the European Union’s Horizon
Europe Research and Innovation programme under grant agreement No. 101092686.
Thank you
www.macrame-project.eu
Steffi Friedrichs
Steffi@AcumenIST.com
+32 496 075 785

19. THANK YOU!
Steffi Friedrichs
D.Phil., Dipl.Chem., Dip.H.E.
AcumenIST
W: www.AcumenIST.com
E: Steffi@AcumenIST.com
T: +32 496 07 57 85
Skype: SteffiFriedrichs

20. The MACRAMÉ Team
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Nanotechnology at the Crossroads of Converging Technologies: Unveiling the Future of Innovation
OIP-2023.eu - 19th October 2023