This document describes the CHOvolution kit, a robust and efficient CHO cell line platform for developing biopharmaceutical products. The CHOvolution kit offers high titers over 7g/L, is GMP compliant, and royalty free. It provides optimized screening and selection protocols as well as customized workshops, audits, and extended support throughout development and manufacturing. Key benefits include significant cost savings, robustness and scalability, technical support, and independence without royalty fees. Celonic offers the CHOvolution kit and additional services to help customers develop cell lines and manufacturing processes.

1. CHOvolution
from R&D to Market
www.celonic.com
OVERVIEW
Our CHOvolution kit is a robust and highly efficient platform
technology that not only adds economic value to your projects
early on, but assures your success in developing your products
to market.
Unlike other commercially available GMP CHO cell line kits,
CHOvolution enables easy and safe GMP compliant develop-
ment with ultra-high titers (>7g/L). Plus, CHOvolution is royalty
free and comes with superior support.
We go beyond and offer optimized screening and selection
protocols, customized workshops and trainings, audits, and
extended support alongside your development and GMP manu-
facturing campaigns.
WHATARE YOUR BENEFITS OF USING CHOVOLUTION?
Are you looking for a high-producing CHO cell line that is also
suitable for GMP manufacturing?
Our CHO cell line is highly scalable, particularly robust and has
already achieved an extremely high product titer of more than
7 g/L for a monoclonal antibody. This means significant cost
savings throughout development, and cost-of-goods reduction
of the final product.
It can be used for a broad range of applications, ranging from
non-GMP R&D applications to GMP product development and
commercial market supply. You save time and money using the
same cell line, and can compare preclinical and clinical results
more easily, which improves project safety.
Are robustness and scalability important to you?
CHOvolution can provide both. The cell line is highly robust and
particularly scalable from shake flask to >1000 L fermentation.
Are you looking fortechnologythat is safe, easy, and ready for use?
The CHOvolution kit includes the cell line that is adapted to
serum and protein-free media an optimized vector set, and all
the information you need for cultivation and handling of the
technology.
You get detailed protocols describing Celonics optimized
screening and selection process to establish production cell
lines for monoclonal antibody products.
You can also get additional support for your GMP development
and GMP manufacturing campaign.

2. www.celonic.com
Do you need expert technical and scientific support?
As a CHOvolution user you have access to extensive internet
support, can communicate directly with our scientific cell line
development experts, and can connect with the CHOvolution
user community in a dedicated forum.
Are you expecting a royalty-free technology and independence
from the licensor?
CHOvolution is a royalty-free host/vector system with a simple
and transparent licensing model for R&D and commercial
application.
After a one-time down payment forthe commercial license, you
are free to use, transfer, sell or sub-license the production cell line.
The technology works with several commercially available me-
dia so you are free to choose your preferred media vendor.
Do you want to extend your partner network?
Extend your client base with your presence on Celonic‘s home-
page as a CHOvolution partner.
What’s your next milestone? Go beyond your expectations with
Celonic!
Based on the QMS audit offered, Celonic guarantees an upgrade
of your generated production cell line to a GMP-compliant
Master Cell Bank.
Ask us about support with subsequent process development, and
clinical and commercial manufacturing of your drug product.
SERVICES
As a CDMO, Celonic takes you further. We provide comprehen-
sive and efficient services from cell line development to process
development and GMP biomanufacturing for clinical and com-
mercial market purposes. Celonic is here for you.
CONTACT
Dr. Ole Fuetterer is available to answer any questions about cell
lines and cell culture, as well as to discuss new opportunities we
can develop for you as your provider and partner.
We look forward to helping you with your projects.
E-mail: ole.fuetterer@celonic.ch
CHOvolution
from R&D to Market