Alzheimer's disease is a progressive brain disorder that destroys memory and thinking skills. It is characterized by beta-amyloid plaques and tau tangles in the brain that initially impact areas involved in memory. As the disease progresses, other brain regions are affected. Currently, there is no cure for Alzheimer's but medications can temporarily improve symptoms by increasing acetylcholine levels or blocking glutamate. About 6.5 million Americans over 65 have Alzheimer's disease, with most cases affecting those over 75. Research continues on treatments to slow the progression of the disease.

1. ALZHEIMER’S DISEASE : SLOW DEAT
Sneha Pandey, Vipin Kumar, Anshika Sharma, Saurabh,
Dr. Shabnam Ain and Dr. Babita Kumar
Introduction
Alzheimer’s disease is a brain disorder that gets worse over time. It’s characterized by
changes in the brain that lead to deposits of certain proteins [1]( beta – amolyid and tau[3]).
Another feature is the loss of connection between nerve cells in the brain. The damage
initially takes place in the part of brain involved in memory, including Entrohinal cortex and
hippocampus.It later affect areas in cerebral cortex [2].
Alzheimer’s disease is the most common cause of dementia — a gradual decline in memory,
thinking, behavior and social skills. AD most commonly affects people over the age of 65[4].
Early signs of the disease include forgetting recent events or conversations. Over time, it
progresses to serious memory problems and loss of the ability to perform everyday tasks.
Medicines may improve or slow the progression of symptoms. There is no treatment that
cures Alzheimer’s disease. In advanced stages, severe loss of brain function can cause
dehydration, malnutrition or infection. These complications can result in death[1].
Pathophysiology :
Cholinergic hypothesis [5]
Amyloid proteins deposition insoluble beta pleated sheets
proteolysed form AB  amyloid beta precursor proteins
Amyolid form A form amyolid paque -- cause AD symptoms.

2. Tau hypothesis [5]
Increased phosphorylation of Tau - free tau increase - loss
neurofibrillary tangles  of paired helical filament
Affect axonal transport proteins --------> neural death.

3. Treatment:
Currently there is no cure. Medicine available that reduce
symptoms temporarily [6].
Acetylcholinestrase : increase level of acetylcholine[6].
Memantine : blocks brain chemical named glutamate[6].
Other druges : antidepressant, anticonvulsant, antipsychotics
and anti- anxiety drug[4].
Aducanumab: helps to reduce amyloid deposits in the brain
and may help slow the progression of Alzheimer’s disease[2].
Results:

4. About 6.5 million people in the United States age 65 and older
live with Alzheimer’s disease. Among them, more than 70% are
75 years old and older. Of the about 55 million people
worldwide with dementia, 60% to 70% are estimated to have
Alzheimer’s disease[1].
Conclusion:
Alzheimer’s disease is a brain disorder that slowly destroys
memory and thinking skills and, eventually, the ability to carry
out the simplest tasks. In advance stages it will leads to death.
Yet no treatment available for this. Medications and therapy
are given to reduce the symptoms.
Reference :
[1] mayoclinic.org
[2]nia.nih.gov
[3] en.m.wikipedia.org
[4]my.clevelandclinic.org
[5]www.researchgate.net
[6]www.nhs.uk