toxopasmosis ppt

1. Azithromycin as a Monotherapy option for P-HIV
Patient with Cerebral Toxoplasmosis Allergic Reaction
to Co-trimozole: A Case Report
Earl Karyl F. Galvez, M.D.
PCGH IM RESIDENT

2. on for P-HIV Patient with Cerebral Toxoplasmosis Allergic Reac

3. Abstract
Toxoplasmosis is the most common
central nervous system infection in
patients with the acquired
immunodeficiency syndrome (AIDS) who
are not receiving appropriate prophylaxis.
This infection has a worldwide
distribution and is caused by the
intracellular protozoan
parasite, Toxoplasma gondii.
Immunocompetent persons with primary
toxoplasmosis are usually asymptomatic,
and latent infection can persist for the life
of the host. In immunosuppressed
patients, especially patients with AIDS,
the parasite can reactivate and cause
disease, usually when the CD4 count
falls below 100 cells/microL Actual Cranial CT scan with Contrast of Patient SP
32/Female

4. Introduction
•Centers for Disease Control and Prevention (CDC) reports that toxoplasmosis is
prevalent worldwide, seen in 11% of the United States (US) population, and can
be as high as 60% in tropical areas.
•Worldwide, there are roughly 13,138,600 cases of Toxoplasma gondii (T. gondii)
co-infection in people living with HIV (PL-HIV)
• CNS toxoplasmosis remains the most common cause of cerebral lesions in
patients living with AIDS without antibiotic prophylaxis. It is also an important
AIDS-defining illness, presenting as the disease progresses without anti-retroviral
therapy (ART), with an onus of high morbidity and mortality

5. Background
The purpose of this Case Report is to
determine the efficacy and tolerance of
azithromycin alone as a monotherapy to
patient adverse reaction to Co-trimoxazole
To shows the summary of presentation,
management, and outcomes of patient after
the used of azithromycin as an alternative.

6. Case report
•Name: SP
•Age: 32
•Gender: female
•Address: Pasig city
•Admitted: March 17, 2023 at PCGH
•CC: Headache with left ear discharge
•PWI: Bacterial meningitis, Immunocompromised, t/c cerebral toxoplasmosis
Course in the Ward: Patient develop SJS after the initiation of Co-trimozaxole with
the other adverse reaction such as gastric reaction such as water stool,
desaturation, worsening of mental status, development of PCP and oral candidiasis

7. Case Discussion
•A 32-year-old previously diagnosed HIV/AIDS female
patient with right-sided cerebellar signs of neurological
deficits and a ring-enhancing lesion in the right
cerebellar hemisphere on CT brain scan. An initial
response to antitoxoplasmic drugs was short-lived due
development of Steven Johnson syndrome,
Pneumocystii Pnuemonia. Multiple electrolytes
imbalance, oral candiasis.

8. Brief Patient clinical
features during the
CIW
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11. Journals 1
Shiojiri, Daisuke et al. “Combination of Clindamycin and Azithromycin as Alternative Treatment for Toxoplasma gondii Encephalitis.” Emerging Infectious Diseases 25 (2019): 841
- 843.
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12. Journal 2
Nasr, Mona El-Sayed et al. “EFFICACY OF AZITHROMYCIN ON EXPERIMENTAL TOXOPLASMOSIS INFECTED MICE.”
Journal of the Egyptian Society of Parasitology 50 (2020): 293-299.
Nasr, Mona El-Sayed et al. “EFFICACY OF AZITHROMYCIN ON EXPERIMENTAL TOXOPLASMOSIS INFECTED MICE.”
Journal of the Egyptian Society of Parasitology 50 (2020): 293-299.