BRAF
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. https://www.antibody-creativebiolabs.com/symbolsearch-braf.htm
1. Antibodies for Melanoma
Research
Antibodies: detection, imaging, diagnostic, etc.
Increase Your Efficiency and Value with
Consistent Performance
info@creative-biolabs.com
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2. Antibodies
for Melanoma Research
Creative Biolabs is the leading antibody service
provider with extensive experience in a variety of
antibody production and engineering field for
both basic science research and pharmaceutic
industries. We offer high quality ready-to-use
catalogue antibodies, as well as flexible and
comprehensive customized services for the
antibody production. With high level professional
scientists and advanced antibody production
platform, we are dedicated to offering various
antibodies for a wide range of applications, and
designing a specific antibody project to tailor the
best service to best fit your requirements.
Trusted Antibody Quality
Earning the trust of researchers
everywhere, every day
01
3. Types Cutaneous Acral Mucosal Ocular/Uveal
Chronic sun
damage
Non-chronic sun damage
Incident 91.2% 2.3% 1.3% 5.2%
Mutated genes KIT, BRAF, NRAS BRAF, NRAS
KIT, BRAF,
NRAS
KIT, NRAS GNAQ, GNA11
Mutated targets
• BRAF
• NRAS
• TP53
• PTEN
• p16INK4a
• p14ARF
• PPP6C
• RAC1
Amplified/deleted targets
• CDKN2A
• PTEN
• TERT
• CCND1
• KIT
• MITF
• CDK4
• MAP2K1
• SNX31
• TACC1
• STK19
• ARID2
• CTNNB1
• PIK3CA
• EZH2
• IDH1
• FBXW7
• KIT
• HRAS
• GNA11
• WT1
A Quick Glance at Key Targets in Melanoma
Kind reminder: If you are interested in any other targets, please visit our website or contact us.
• p75NGFR
• CD133
• CSPG
• ALDH1
• CD20
• JARID1A
• ABCB5
Markers
Signaling pathway targets
• PI3K
• PTEN
• RAC
• AKT
• NF-kB
• mTOR
• MDM2
• p53
• CDKs
• ERK
• MEK
• BRARAS
• MC1R
• IGF1-R
• EGFR
• PDGFRβ
• FGFR
• HGFR
Melanoma
Melanoma, the deadliest skin cancers, is caused by
the transformation of melanocytes which
accumulate genetic alterations, leading to abnormal
proliferation and dissemination.
Incidence, types, and associated mutant genes
Melanoma
02 info@creative-biolabs.com www.antibody-creativebiolabs.com
Antibodies
for Melanoma Research
4. Popular Creative Biolabs’ antibodies for melanoma key factors
Creative Biolabs’ antibodies help meet your melanoma cancer research needs and budget requirements, increasing
efficiency and offering the best value for a wide range of applications and specific assays.
Targets Clone Applications Species reactivity Cat.No.
BRAF
CBYY-2108 IHC, IPS, WB Human, Monkey CBMAB-2457-YY
CBYY-2024 IC, IHC, IPS, WB Human, Dog, Monkey, Rat CBMAB-2373-YY
EP152Y WB, IPS, FC, IP Mouse, Rat, Human CBMAB-1219-CN
NRAS
RBT-NRAS IFS, IPS Human CBMAB-N0518-WJ
2G9 WB, FC, E, IF Human CBMAB-N0517-WJ
CBWJN-0812 WB, FC, IP Mouse, Rat, Human CBMAB-N3523-WJ
TP53
1285C WB, IHC, IF, IPS, FC Human, Mouse CBMAB-1838CQ
CBWJW-083 WB, IPS, PE Human, Mouse, Rat CBMAB-T0002-WJ
1F7 IP, M, WB Human CBMAB-0266-LY
PTEN
10BA32 IF, WB Human CBMAB-1515CQ
10BA33 IF, WB Human CBMAB-1516CQ
10BA34 WB Human CBMAB-1517CQ
p16INK4a
1E12E10 WB, P Human, Mouse, Rat CBMAB-C3919-LY
5-C3 WB, IP, C, IC/IF Mouse CBMAB-C7384-LY
3F3 E, WB Human CBMAB-C6031-LY
RAC1
4A4B11 E, IF, IH, IP, WB Human, Mouse, Rat CBMAB-R0993-CN
2180C3a DB, IC Human CBMAB-C0644-LY
0.T.127
WB, IP, E, P, C, F, P,
IF
Mouse, Rat, Rabbit, Human CBMAB-R0988-CN
MAP2K1
CBFYM-1440 F, IC, IF, P, WB
Human, Mouse, Non-human
primate, Rat
CBMAB-M1600-FY
25/MEK1 F Human, Chicken, Dog, Mouse, Rat CBMAB-M0108-FY
CBFYM-0552 IC, IF, IH, IP, WB Human CBMAB-M0681-FY
ARID2
CBYC-A766 DB, IC, WB Human, Mouse, Rat CBMAB-A3547-YC
1A1 IP, M Human CBMAB-0127-YC
13HCLC F, IC, IF, WB Human, Mouse CBMAB-0051-WJ
CTNNB1
8E4 E, IC/IF, WB, P Human, Mouse, Rat CBMAB-C9162-LY
7A7 IA, IF, P, WB Human, Mouse, Rat CBMAB-C8567-LY
6B3 WB, IP, P, C
Human, Mouse, Rat, Monkey,
Xenopus, Cattle, Dog, Pig
CBMAB-C8091-LY
EZH2
6G4F4 WB, F, E, IH, IC, MC Human CBMAB-E0234-FY
1B3 CI, IP, M Human CBMAB-0366-YC
CBFYE-1433 IF, IH, IP, WB Human, Monkey, Mouse, Rat CBMAB-E2059-FY
IDH1
1D1 P, WB Human CBMAB-I0237-YY
IDH1/1152 C, WB, F, P, IF, MC Human CBMAB-I0238-YY
CBYY-I0585 WB, IH, E Human, Dog, Rat, Monkey, Mouse CBMAB-I1288-YY
FBXW7
SP237 P, F Human, Mouse, Rat CBMAB-F0223-CQ
3D1 WB, E, P, SE Human CBMAB-F0835-CQ
FBOX 3a9/1 WB, F, IH, IF, IP, MC Human, Mouse CBMAB-F0065-CQ
Antibodies for mutated targets in Melanoma
03
Antibodies
for Melanoma Research
info@creative-biolabs.com
To be continued.
www.antibody-creativebiolabs.com
5. Targets Clone Applications Species reactivity Cat.No.
KIT
5C8D4 WB, E, IH, P Human CBMAB-C7434-LY
3A8 E, WB Human CBMAB-K0974-LY
104D2 F Cattle, Human, Monkey CBMAB-K0116-LY
HRAS
1C8 WB Human, Monkey CBMAB-G6073-LY
1A1 WB Mouse, Rat, Dog, Human, Monkey CBMAB-G6072-LY
CBFYH-1956 IF, C, P, IP, N, WB Human CBMAB-H2967-FY
GNA11 CBLG1-3194 WB Mouse, Rat, Human CBMAB-G4050-LY
WT1
6F-H2 WB, P, C, IP Human, Mouse, Rat CBMAB-W0142-WJ
WT1/857 F, IF, IH Human, Mouse, Rat CBMAB-W0384-WJ
RMWT1-1 IF, P Human CBMAB-W0376-WJ
Antibodies for mutated targets in Melanoma
Targets Clone Applications Species reactivity Cat.No.
CDKN2A
1E12E10 WB, P Human, Mouse, Rat CBMAB-C3919-LY
5-C3 WB, IP, C, IC/IF Mouse CBMAB-C7384-LY
3F3 E, WB Human CBMAB-C6031-LY
PTEN
10BA32 IF, WB Human CBMAB-1515CQ
10BA33 IF, WB Human CBMAB-1516CQ
10BA34 WB Human CBMAB-1517CQ
TERT CBFYE-1667 WB, IC, P, C, E Human CBMAB-E2336-FY
CCND1
1F7 WB Human CBMAB-C4075-LY
2G3G5 E, C, WB Human, Mouse, Rat, Zebrafish CBMAB-C5177-LY
17H3L3 F, IC, IF, WB Human CBMAB-C3434-LY
KIT
5C8D4 WB, E, IH, P Human CBMAB-C7434-LY
3A8 E, WB Human CBMAB-K0974-LY
104D2 F Cattle, Human, Monkey CBMAB-K0116-LY
MITF
1D9 IP, WB, M Human CBMAB-0676-YC
CBFYM-0644 E, IH, WB Human CBMAB-M0780-FY
CBFYM-2242 WB Dog, Horse, Human, Mouse, Rat CBMAB-M2426-FY
CDK4
4F11 E, IF, WB Human CBMAB-C6910-LY
2G7 E, IF, WB Human CBMAB-C5208-LY
0.N.199 IF, IP, WB Human, Mouse, Pig, Rat CBMAB-C1404-LY
Antibodies for amplified/deleted targets in Melanoma
To be continued.
04
Antibodies
for Melanoma Research
info@creative-biolabs.com www.antibody-creativebiolabs.com
6. To be continued.
Targets Clone Applications Species reactivity Cat.No.
CD20
4A4 P, WB Human CBMAB-C6595-LY
B9E9 E, F, C, IP Human CBMAB-M0301-FY
2H7 D, CI, IP Human, Monkey CBMAB-0947-LY
ABCB5
13B6 E, F, IC, IH, WB Human CBMAB-A0214-YC
5H3C6 E, F, IC, IF, IH, P, WB Human CBMAB-A0215-YC
CBYC-A135 WB, IC, P, C, E Human CBMAB-A0216-YC
Antibodies for markers of Melanoma
05
Targets Clone Applications Species reactivity Cat.No.
CD133
13A4 F, C, IP, WB Dog, Mouse CBMAB-C0309-LY
13B112 E, F, IH Human CBMAB-C2770-LY
170411 F, MC Human CBMAB-C0422-LY
CSPG
9.9.27 F, IF, IP Human CBMAB-C9303-LY
132.38 WB, IP, E, C, P, IC Mouse, Rat CBMAB-N0688-WJ
7G4E5 WB, E, F Human CBMAB-1458-CN
ALDH1
5A11 E, IH, P, WB Human CBMAB-A2246-YC
1G6 E, P, IP, WB Human CBMAB-A2245-YC
1A10A2 E, IF, IH, WB Human, Mouse, Pig, Rat CBMAB-A2243-YC
Antibodies for markers of Melanoma
Antibodies
for Melanoma Research
info@creative-biolabs.com www.antibody-creativebiolabs.com
7. Targets Clone Applications Species reactivity Cat.No.
PTEN
10BA32 IF, WB Human CBMAB-1515CQ
10BA33 IF, WB Human CBMAB-1516CQ
10BA34 WB Human CBMAB-1517CQ
RAC1
4A4B11 E, IF, IH, IP, WB Human, Mouse, Rat CBMAB-R0993-CN
2180C3a DB, IC Human CBMAB-C0644-LY
0.T.127 WB, IP, E, P, C, F, P, IF Mouse, Rat, Rabbit, Human CBMAB-R0988-CN
AKT1
9Q7 P, WB Human, Mouse, Rat CBMAB-A2060-YC
18F10.E5 E, WB, IH Human, Mouse, Rat, Chimpanzee CBMAB-A2022-YC
3B4 IF, F, IH, WB Human, Dog, Rat, Monkey, Mouse CBMAB-A2043-YC
mTOR
12F10-5F11 IF, IH, IP Common fruit fly CBMAB-0019-CN
CBFYM-1208 WB, IP, P, IC Mouse, Human CBMAB-M1365-FY
CBYJL-1176 WB, IP, P, IF Human, Mouse, Rat, Monkey CBMAB-L0675-YJ
MDM2
CBFYM-0419 WB, IP, E, P, C, F Mouse, Rat, Human CBMAB-M0532-FY
CBFYM-0613 IF, IH, IP, WB Human CBMAB-M0746-FY
CBFYM-1962 C, P, IP, WB Human, Mouse CBMAB-M2137-FY
p53
CBWJW-083 WB, P, PE Human, Mouse, Rat CBMAB-T0002-WJ
CBLG1-2390 IF, SE, E, WB Human CBMAB-G6398-LY
25F4 IF, IH, IP, WB Common fruit fly CBMAB-0432-LY
CDK1
26E11 WB, E, IP, P Human, Mouse, Rat CBMAB-C4505-LY
3G92 E, IH, IP, WB Chicken, Human, Rd CBMAB-C6197-LY
1A6 E, F, IC, IF, C, WB Human CBMAB-C3564-LY
ERK1
1D1 E, IP, WB Human CBMAB-0633-YC
4C11 E, IC, IF, IH, C, P, WB Human, Mouse, Monkey CBMAB-1201-YC
5AD13MA IC, IF, P, WB Human, Mouse, Rat CBMAB-E0215-FY
MEK1
25/MEK1 F Human, Chicken, Dog, Mouse, Rat CBMAB-M0108-FY
CBFYM-1441 WB, P, IF, IP Human, Mouse, Rat, Zebrafish CBMAB-M1601-FY
CBFYM-1437 WB, IP, IF, E Mouse, Rat, Human CBMAB-M1597-FY
MC1R
CBFYM-1849 WB Human, Mouse, Rat CBMAB-M2017-FY
CBFYM-1848 E, WB Human CBMAB-M2016-FY
CBFYM-1847 IH, WB Human CBMAB-M2015-FY
EGFR
111.6 F, IC, IF, P, IP, WB Human, Mouse CBMAB-E0954-FY
Matuzumab F Human CBMAB-E0089-FY
GFR450 F, IP, N, MC Human CBMAB-E0086-FY
PDGFRβ
42G12 P, WB Human, Mouse, Rat CBMAB-C6479-LY
21/72 IC/IF, IP, WB, P Human, Monkey CBMAB-C4362-LY
28D4 F Human CBMAB-C0790-LY
Antibodies for signaling pathway related targets in Melanoma
To be continued.
06
Antibodies
for Melanoma Research
info@creative-biolabs.com www.antibody-creativebiolabs.com
8. Antibodies for signaling pathway related targets in Melanoma
Targets Clone Applications Species reactivity Cat.No.
FGFR
BA0345 IF, WB Human CBMAB-0295CQ
CBXF-0601 WB, IP, P, IF, F Human, Mouse, Rat, Monkey CBMAB-F1391-CQ
CBXF-1878 E, ED Mouse CBMAB-F3412-CQ
HGFR
3D4 E, IH, IP, WB Human CBMAB-C1095-LY
1G7NB IH, IF, P, F Human CBMAB-H0399-FY
4AT259 WB, IF Human, Mouse CBMAB-H3681-FY
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Creative Biolabs owns comprehensive mono-antibody products and related services. Please contact us for
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serve you to help promote your projects. The list above only exhibit a small part of our products. Please
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Antibodies
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9. Custom Antibody Service Process
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With extensive experience and over a decadesupeior antibody services for numerous worldwide
customers, Creative Biolabs has blossomed into a service leader in the field of antibody products
and services. We offer a comprehensive set of package services and also individual modules, and
aim to maximize the success of your melanoma research discovery and development.
A wide range of
applications
Antibodies
for Melanoma Research
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10. The trusted antibody and
custom service & solution provider.
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Expedite Your
Melanoma Research
Leverage the expertise of our senior scientists to obtain
antibodies or custom products to fit your project.
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Our promise:
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