5. • The most common inherited single-gene
disorder in the world.
• Highest prevalence in areas where malaria was
or still is endemic.
• Globally, an estimated 15 million people have
thalassemia.
• 5000 children in Pakistan are diagnosed with
thalassemia major every year
13. Confirmed laboratory diagnosis of β-
homozygous thalassaemia major
Hb < 7g/dl on 2 occasions, > 2 weeks apart
(excluding all other contributory causes such as
infections)
Hb >7g/dl with facial changes, poor growth,
fractures and extramedullary hematopoieses.
14.
15. Any Healthy Person with
Weight > 45 kg
Hb level >12.5g/dl
Age 18-60 years
Not have donated blood in last 56 days
16. • Unfortunately, Pakistan is one of those countries where blood
donation rate is less than 1%
• As per international standards if one to three percent of any
country’s population donates blood, it would be sufficient to
meet country’s requirement of blood transfusion
• Annually we face shortage of around 1.4 million blood units
against the demand of around 3.2 million units.
17. 1.Blood donation is a Life Saver!
2.There is no Substitute for Blood.
3.Every 3 seconds someone needs
a blood transfusion!
4.Your donation will help save the
life of upto 3 people!
5.Blood is the the most precious
gift that anyone can give to another
person.
6. Its Free !
Thalassemia is a genetic disorder in which the body produces an abnormal form of hemoglobin that tend to accumulate in the red blood cells due to which there is extensive red cell destruction as a result fewer healthy rbc are left which leads to anemia.
Now some facts about thalassemia.
Now very briefly I will go through the pathophysiology of thalassemia.
This is a normal hemoglobin molecule which is a tetramer composed up of 2 alpha and 2 beta globin chains. Thalassemia occurs when there is a defect in a gene that is controlling the production of these chains.
So depending upon which gene is affected . Thalassemia is classified into two types. Alpha and beta. As the name indicates, in alpha thalassemia there is a defect in alpha globin gene due to which there is decresead production of alpha globin chain and an increased accumaltion of beta globin chain.
Normally there are 4 alpha globin genes on chromose 16. severity of disease depends on number of genes affected.
Now coming to beta thalassemia.. Unlike alpha globin.. There is only one beta globin gene on chromosome 11. so the person can either be homozygous or heterozygous and the condition is known as beta thalassemia minor and major respectively. And beta thalassemia major is a serious life …….
You can see in this graph that as the severity of anemia increases the likelihood of blood transfusion is also increasing.
Because donating blood is a life saving measure. There is no subsitute for it. One cannot make blood, it is a gift we all have inside of us to give to those who are in need. Every 3 seconds someone needs a blood transfusion. And your donation will help save ….. . And the biggest reason is that it costs you nothing to save a life. Its free !
Studies have proved that donating blood is associated with a reduced risk of heart diseases, cancer, it removes excess iron from your body. It helps you to burn calories. And you get to have a free health check up every 3 months if u are donating regularly. And the biggest of all is the ultimate joy of saving human lives.
And the goals of your education should be to change the knowledge attitude and beliefs of people which results in a changed behavior. And when people understand the importance of safe blood they are automatically motivated and recruited. So step by step these education goals can lead you to your final destination.
