2. DRUG DOSAGE FORMS
DESIGN LABORATORY
HTTP://PHARMCLUSTER.RU/LABS/ENG/DESIGN-OF-DOSAGE-FORMS/
Head of DDFDL LSC MIPT
Ph.D. in Medical Science,
Associate Professor in Toxicology,
Sergei P. Krechetov
ksp@pharmcluster.ru
28.09.2016 2
6. LABORATORY R&D SCOPE
14.08.2013 6
1) Investigation of active pharmaceutical ingredients
(API) with
• low bioavailibility,
• low stability,
• adverse side effect,
• poor technological properties,
• …
2) R&D of drug delivery systems for improving safety
and efficiency of API
3) R&D of dosage forms with the modified release of API
for higher safety and efficiency of drugs
7. LABORATORY R&D
PROCESS FLOW DIAGRAM
14.08.2013 7
Pharmaceutical testing
(in vitro)
Drug dosage form
development
Drug delivery system
development
?… Data about
excipients
New
API
Known
API
Data about
API
Preclinical and clinical investigation
8. DRUG DOSAGE FORMS
WITH MODIFIED RELEASE
UNDER DEVELOPMENT:
– solid (powders, pellets, capsules, tablets);
– soft (ointments, creams, gels);
– liquid (suspensions, emulsions)
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9. 28.09.2016 9
DRUG DELIVERY SYSTEMS
UNDER DEVELOPMENT:
(micro- and nanodispertions of different nature)
– microparticles;
– suspensions (liposomes, cochleates, …);
– emulsions;
– solubilizates;
– gels;
– molecular complexes (cyclodextrins, …);
– …
