following PPT contain detailed information of optimization its concept and parameters of optimization in very easy language to understand

1. Concept Optimization and
parameters of Optimization
Nikam Saurabh Devidas
F.Y. M Pharmacy
K.B.H.S.S.Trsust.IOP. Malegoan

2. Concept of Optimization
 The Term optimize is defined as: To make perfect
 t is the process of finding the best way of using the existing
resources while taking in to the account of all the factors that
influences decisions in any experiment
 Traditionally, optimization in pharmaceuticals refer to changing
one variable at a time, so to obtain solution of a
problematic formulation,
 Optimization is an process of making system or decision as perfect
and functional.

3. Why optimization is necessary ?
 Main objective is to
prepare the best
formulation under a
given set of
restrictions.

4. Applications
 Formulation and Processing
 Clinical Chemistry
 Medicinal Chemistry
 High Performance Liquid Chromatographic Analysis
 Formulation of Culture Medium in Virological Studies.
 Study of Pharmacokinetic Parameters.

5. Parameters of optimization
Optimization Parameters
A) Problem
Type
B) Variables
1)
Constrained
2)
Unconstrained
1) Dependent 2)
Independent

6. A) Problem Type
 There are two general type in the problem type of optimization
technique:
1. Constrained
2. Un constrained

7. 1) Constrained problems
 These are the restrictions placed on the system by physical limitations
 In the Constrained optimization problems have restriction on it .
 Example: To make hardest tablet as possible but it must disintegrate in 15
min , the disintegration time is an restriction to formulate hardest tablet as
possible
 Economical consideration

8. 2. Un constrained Problems
 In Un constrained optimization problems there are no
restrictions on them
 Example : To make hardest tablet as possible , there are no
restriction to make hardest tablet

9. B) Variables
 There are two general type in the Variables of optimization
technique:
1) Dependent Variables
2) Independent Variables

10. 1) Dependent Variables
 The dependent variables are the responses or the
characteristics that are developed due change to the
independent variables.
 The more the variables present in the system the more the
complications are involved in the optimization.
 This variables are not in control of formulator , they change
when independent variables change

11. 2) Independent Variables
 The independent variables are under the control of the
formulator.
 Formulator change this variables to prepare effective , stable
and efficient Formulation.
 These might include the compression force or the die cavity
filling or the mixing time.

12. Examples of Dependent and independent Variables
independent Variables Dependent Variables
Diluent Ratio Disintegration Time
Compressional force Hardness
Disintegrant Concentration Dissolution
Binder Level Friability
Lubricant level Weight uniformity