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PATHOPHYSIOLOGY OF CCF
NCPA Page 1
CONGESTIVE CARDIAC FAILURE
DEFINITION;
Congestive heart failure is a clinical syndrome in which the heart is unable to pump sufficient
blood to meet the metabolic requirements of the body
EPIDEMOLOGY;
 HF is a burgeoning problem worldwide with more than 20 million people affected.
The overall prevalence of HF in the adult population in developed countries is 2%.
HF prevalence follows an exponential pattern , rising with age , and affects 6-10% of
people over age 6
 Although the relative incidence of HF is lower in women than in men , women
constitute at least one - half the cases of HF because of their longer life expectancy
TYPES;
1 .Left ventricle failure; Failure occurs solely in the left ventricle signs and symptoms are
related to congestion of lung
2 .Right ventricle failure; Failure occurs in the right ventricle, signs and symptoms
related to systemic congestion
3 .Congestive heart failure; Combination of both left and right ventricles failure
4.Diastolic heart failure; Heart muscles become stiffer than normal leads to lack of blood
flow to the rest of the organs in your body. It is common in women than in men
5. Systolic heart failure; Heart muscles loses its ability to contract. It is more common in
men than in women
ETIOLOGY AND REASONS
 Reduction in muscle mass
 Dilated cardiomyopathies
 Ventricular hypertrophy - 1. Pressure overload
2 .Volume overload
 Increased ventricular stiffness
 Ventricular hypertrophy
 Myocardial ischemia and infarction
 Pericardial diseases
PATHOPHYSIOLOGY OF CCF
NCPA Page 2
PATHOPHYSIOLOGY;
To understand the pathophysiologic process in heart failure understanding of cardiac function
is necessary
Cardiac output = Heart rate x Stroke volume
The cardiac performance depends on four factors
1 .Preload
2 .Afterload
3. Contractility
4 . Heart rate
PATHOPHYSIOLOGY OF CCF
NCPA Page 3
CLINICAL MANIFESTATIONS;
Dyspnea
Orthopenia
Tachypnea
Cough
Fatigue
Abdominal pain
Nausea
Bloating
Ascites
Poor appetite
Mental status changes
LABORATORY INVESTIGATIONS;
Blood profile
Serum creatinine and urea levels
Liver function tests
Thyriod function tests
ECG
ECHO
Chest radiography
PATHOPHYSIOLOGY OF CCF
NCPA Page 4
PATHOPHYSIOLOGY OF CCF
NCPA Page 5

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Pathophysiology of Congestive Cardiac Failure

  • 1. PATHOPHYSIOLOGY OF CCF NCPA Page 1 CONGESTIVE CARDIAC FAILURE DEFINITION; Congestive heart failure is a clinical syndrome in which the heart is unable to pump sufficient blood to meet the metabolic requirements of the body EPIDEMOLOGY;  HF is a burgeoning problem worldwide with more than 20 million people affected. The overall prevalence of HF in the adult population in developed countries is 2%. HF prevalence follows an exponential pattern , rising with age , and affects 6-10% of people over age 6  Although the relative incidence of HF is lower in women than in men , women constitute at least one - half the cases of HF because of their longer life expectancy TYPES; 1 .Left ventricle failure; Failure occurs solely in the left ventricle signs and symptoms are related to congestion of lung 2 .Right ventricle failure; Failure occurs in the right ventricle, signs and symptoms related to systemic congestion 3 .Congestive heart failure; Combination of both left and right ventricles failure 4.Diastolic heart failure; Heart muscles become stiffer than normal leads to lack of blood flow to the rest of the organs in your body. It is common in women than in men 5. Systolic heart failure; Heart muscles loses its ability to contract. It is more common in men than in women ETIOLOGY AND REASONS  Reduction in muscle mass  Dilated cardiomyopathies  Ventricular hypertrophy - 1. Pressure overload 2 .Volume overload  Increased ventricular stiffness  Ventricular hypertrophy  Myocardial ischemia and infarction  Pericardial diseases
  • 2. PATHOPHYSIOLOGY OF CCF NCPA Page 2 PATHOPHYSIOLOGY; To understand the pathophysiologic process in heart failure understanding of cardiac function is necessary Cardiac output = Heart rate x Stroke volume The cardiac performance depends on four factors 1 .Preload 2 .Afterload 3. Contractility 4 . Heart rate
  • 3. PATHOPHYSIOLOGY OF CCF NCPA Page 3 CLINICAL MANIFESTATIONS; Dyspnea Orthopenia Tachypnea Cough Fatigue Abdominal pain Nausea Bloating Ascites Poor appetite Mental status changes LABORATORY INVESTIGATIONS; Blood profile Serum creatinine and urea levels Liver function tests Thyriod function tests ECG ECHO Chest radiography