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Tuning Materials. Enhancing Lives.
Tonny Voermans, M.Sc.
Managing Director
confidential2
The issues of cure
▲ Drugs and medical devices become more advanced, but
still pose challenges
▲ Another issue is suboptimal handling of the device
▲ Current issues are:
▲ Complex diseases with a variety of causes and treatments
▲ Overmedication (of antibiotics)
▲ Extensive cure need due to hospitalization
confidential3
Mission
▲ Improve the treatment options for patient and surgeon
▲ Improved working
▲ Longer efficacy (degradation)
▲ Target release
▲ Enhanced handling
▲ Better applicators
▲ Extension application areas
▲ Change functional form
confidential4
Elements as innovation
▲ New technologies offer new treatment solutions
▲ Biopolymers are used as devices or carriers for drugs or
tissues: viscosupplements and hemostasis products
▲ BioMed Elements has a technology platform to optimize
the behavior of medical devices by tuning the basic
elements of the polymers
confidential5
Examples Biopolymers
Gelatine
Hyaluronic Acid
Collagen
Chitosan
Alginate
Cellulose
Soy
confidential6
Biomaterials market
Market Size CAGR
Biomaterials 70 B 16%
Plastic surgery 6,5 B 14%
Orthopaedic 22 B 5%
Dental 6,6 B 7%
Hemostasis 1,5 B 4%
Tissue engineering 2,1 B 10%
The key market players are Royal DSM, Wright Medical Technology, Inc., Corbion
N.V., Zimmer Biomet Holdings, Inc., Bayer AG, Carpenter Technology Corporation,
Covalon Technologies Ltd., BASF SE, Invibio Ltd., Berkeley Advanced Biomaterials,
Inc., and Collagen Matrix, Inc. among others.
http://www.biomatin.eu/pdf/Regional_analysis_of_the_biomaterial_market.pdf
http://providencehightech.com/biomaterials-trends-forecasts/
confidential7
BioMed Core Technology
Source Material Core Technology Spherical Submicron Particles
▲ Access to well defined spherical submicron particles
▲ Control over parameters (e.g. size, density)
▲ Patented continuous process:
▲ Upscaling is possible
▲ High consistent quality
1µm
confidential8
Functional Forms
Suspension Powder GelSponge
Resorbable HemostatResorbable Scaffold Flowable Carrier
Application: Application: Application:Application:
Drug Carrier
Application Areas: orthobiologics, wound management, tissue engineering,
medical aesthetics and cosmetics.
confidential9
Business model
▲ Contract research and co-development:
▲ Feasibility study and product optimization
▲ Analytical study
▲ Contract manufacturing:
▲ Medical devices and half fabricates manufacturing
▲ Development own product range:
▲ Developing a range of niche products
confidential10
Value proposition
Phase 1:
Feasibility study for
improved or new
product
Phase 2:
Proof of concept;
lock in of IP
Phase 3:
Upscaling of
manufacturing
based on BioMed
expertise and
manufacturing
capabilities
Phase 4:
Manufacturing and
distribution of
device
confidential11
Current partners
▲ Netherlands: HCM Medical, Avivia, Fibriant, Leader
Biomedical and Zuyderland hospital.
▲ Europe: Mathys Medical (Switzerland), OST
Developpement (France) and Sirakoss (United Kingdom).
▲ USA: Pro-Tech Design, Alamo Tissue Services, Synergy
BioMedical, Celling Biosciences and Vivex Biomedical.
confidential12
Development route
▲ Phase 1: Hemostatic range
▲ Hemostatic gel for various applications
▲ Sponge for heavy bleedings with active
confidential13
Development route
▲ Scenario 2: Hyaluronic acid products
▲ Dermal filler
▲ Viscosupplement
confidential14
Do’s and don’ts
▲ Be stubborn, but also look for people who are even more
stubborn
▲ Be smart on how to persuade investors
▲ Hold perspective on success; by yourself as well as from
others
▲ Use network opportunities
▲ Luck = your effort + what others help you with
confidential15
BioMed’s future
▲ Investment need for validation of haemostatic gel
▲ Set up and strengthen partner network
▲ Perform animal study for heavy bleedings product Q2
2018
▲ Market access in ENT surgery products
And what the future brings
“Tuning Materials. Enhancing Lives.”

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171123 Presentation BioMed Elements

  • 1. Tuning Materials. Enhancing Lives. Tonny Voermans, M.Sc. Managing Director
  • 2. confidential2 The issues of cure ▲ Drugs and medical devices become more advanced, but still pose challenges ▲ Another issue is suboptimal handling of the device ▲ Current issues are: ▲ Complex diseases with a variety of causes and treatments ▲ Overmedication (of antibiotics) ▲ Extensive cure need due to hospitalization
  • 3. confidential3 Mission ▲ Improve the treatment options for patient and surgeon ▲ Improved working ▲ Longer efficacy (degradation) ▲ Target release ▲ Enhanced handling ▲ Better applicators ▲ Extension application areas ▲ Change functional form
  • 4. confidential4 Elements as innovation ▲ New technologies offer new treatment solutions ▲ Biopolymers are used as devices or carriers for drugs or tissues: viscosupplements and hemostasis products ▲ BioMed Elements has a technology platform to optimize the behavior of medical devices by tuning the basic elements of the polymers
  • 6. confidential6 Biomaterials market Market Size CAGR Biomaterials 70 B 16% Plastic surgery 6,5 B 14% Orthopaedic 22 B 5% Dental 6,6 B 7% Hemostasis 1,5 B 4% Tissue engineering 2,1 B 10% The key market players are Royal DSM, Wright Medical Technology, Inc., Corbion N.V., Zimmer Biomet Holdings, Inc., Bayer AG, Carpenter Technology Corporation, Covalon Technologies Ltd., BASF SE, Invibio Ltd., Berkeley Advanced Biomaterials, Inc., and Collagen Matrix, Inc. among others. http://www.biomatin.eu/pdf/Regional_analysis_of_the_biomaterial_market.pdf http://providencehightech.com/biomaterials-trends-forecasts/
  • 7. confidential7 BioMed Core Technology Source Material Core Technology Spherical Submicron Particles ▲ Access to well defined spherical submicron particles ▲ Control over parameters (e.g. size, density) ▲ Patented continuous process: ▲ Upscaling is possible ▲ High consistent quality 1µm
  • 8. confidential8 Functional Forms Suspension Powder GelSponge Resorbable HemostatResorbable Scaffold Flowable Carrier Application: Application: Application:Application: Drug Carrier Application Areas: orthobiologics, wound management, tissue engineering, medical aesthetics and cosmetics.
  • 9. confidential9 Business model ▲ Contract research and co-development: ▲ Feasibility study and product optimization ▲ Analytical study ▲ Contract manufacturing: ▲ Medical devices and half fabricates manufacturing ▲ Development own product range: ▲ Developing a range of niche products
  • 10. confidential10 Value proposition Phase 1: Feasibility study for improved or new product Phase 2: Proof of concept; lock in of IP Phase 3: Upscaling of manufacturing based on BioMed expertise and manufacturing capabilities Phase 4: Manufacturing and distribution of device
  • 11. confidential11 Current partners ▲ Netherlands: HCM Medical, Avivia, Fibriant, Leader Biomedical and Zuyderland hospital. ▲ Europe: Mathys Medical (Switzerland), OST Developpement (France) and Sirakoss (United Kingdom). ▲ USA: Pro-Tech Design, Alamo Tissue Services, Synergy BioMedical, Celling Biosciences and Vivex Biomedical.
  • 12. confidential12 Development route ▲ Phase 1: Hemostatic range ▲ Hemostatic gel for various applications ▲ Sponge for heavy bleedings with active
  • 13. confidential13 Development route ▲ Scenario 2: Hyaluronic acid products ▲ Dermal filler ▲ Viscosupplement
  • 14. confidential14 Do’s and don’ts ▲ Be stubborn, but also look for people who are even more stubborn ▲ Be smart on how to persuade investors ▲ Hold perspective on success; by yourself as well as from others ▲ Use network opportunities ▲ Luck = your effort + what others help you with
  • 15. confidential15 BioMed’s future ▲ Investment need for validation of haemostatic gel ▲ Set up and strengthen partner network ▲ Perform animal study for heavy bleedings product Q2 2018 ▲ Market access in ENT surgery products And what the future brings