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Royal DSM is a global science-based
company active in health, nutrition
and materials.
Our mission
DSM’s purpose is to create brighter lives
for people today and generations to come.
DSM
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3. We are committed to create a sustainable future
Thank you for inspiring us, challenging us and supporting us in our
mission to create brighter lives for people today and generations to
come.
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Named #2 on Fortune Magazine’s
Change the World list
Leader Dow Jones Sustainability
Index and Sustainalytics
4. Net sales by destination (%)
Africa:
73 employees
North America
> 3,000
Europe
> 9,000
Asia
> 6,000
RoW
> 250
Latin America
> 2,000
Global workforce (FTE)
JV’s
~ 5,000
DSM global presence
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29%
23%12%
12%
10%
6%3%
3%
2%
Western Europe North America
Latin America China
Rest of Asia Eastern Europe
Japan Rest of the World
India
5. 15%
6%
11%
4%
31%
5%
7%
6%
8%
6%
Key markets
Food &
Beverages
Electrical &
Electronics
Automotive
Building &
Construction
Other
Infant
nutrition
Dietary
Supplements
Animal Feed
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Personal
Care
(Food)
Packaging
DSM offers products & solutions to a wide range of markets
Dairy
RTE meals
Soups / Sauces / Spreads
Wine-Beer-Fruit drinks
Materials
sciences
Life
sciences
6. Examples of
nutritional products of DSM
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Vitamins
Carotenoids
Nutritional
Lipids
Feed
Enzymes
Examples of
materials of DSM
Food & Beverage
Enzymes
Minerals
for animals
Yeasts, cultures
and probiotics
High performance
engineering
thermoplastics
DSM Dyneema
Innovative resins
for sustainable
coatings systems
High-performance
UV-curable optical
fiber materials
7. DSM
Biomedical
Exton, PA
Geleen, The Netherlands
Berkeley, CA
Greenville, NC
Your biomedical partner,
trusted by the medical
industry to shape the future
of medical devices with
advanced healing
technologies that improve
and brighten patients’ lives
throughout the world.
A division of Royal DSM
8. Every 9 seconds,
a patient receives
a DSM biomedical
based solution
3.5M+ patients with
our devices annually
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Beyond Science to Solutions™
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DSM has unmatched
global reach and
resources
We have decades of
successful research and
scientific innovation
We are addressing trends in
medicine to create better
outcomes for patients
Global
Partner
Solutions
Provider
Innovator
• Building successful
partnerships with medical
device companies for more
than 25 years
• Over 400 Biomedical
specialists
• 1,032 patents filed and
counting
• More than 30 U.S. and 15
OUS regulatory clearances
• Conducted over 170 pre-
clinical and clinical studies
• More than 200 clinicians, 90
hospitals and 40 university
physicians are engaged in our
R&D
• $25M invested in research
annually
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Deep understanding of our partners and
clinical markets
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Market Growth
Drivers
•Aging Population
•Rise in metabolic
disease (Diabetes,
Obesity)
•Premium placed
on delivering
positive clinical
outcomes
•Product
differentiation
thru delivering
healthcare
economical value
Market Challenges
•Outcomes Based
Reimbursement
•Increased
demands on
efficacy and
outcomes
evidence
•Pricing Pressures
•Increasingly
commoditized
market
•Regulatory
barriers
•Consolidation and
integration
Opportunities
DSM brings
•Proven advanced
healing solutions
from biomaterials
to finished
devices
•Unmatched global
reach and
resources
•DSM’s portfolio
breadth provides
single source
solution to enable
further
integration and
consolidation,
reducing costs
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Partnering with DSM
from Concept to Commercialization
Conceptualization
& Ideation
Research &
Development
Clinical &
Regulatory
Scale-up &
Manufacturing
Commercial
Support
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One partner with the broadest platform of
advanced healing solutions
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Bioceramics Extracellular
Matrix
Polyethylenes
CollagenCell
Concentration
PolyurethanesHydrophilic
Coating
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Bioceramics
Greatest selection of components and devices for bone repair
• Tunable scaffold combinations
– Remodeling time
– Handling
– Delivery
• Over 100,000 synthetic bone grafts per
year
• Full range of bioceramic material
options
– Carbonated apatite
– Bioactive glass
– Calcium phosphates
– Compounded with other biomaterials
• Multiple configurations
– Powders, granules (solid & porous)
– Porous shapes (wedge, cylinder)
– Settable pastes / putties / injectables
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1 Parrish WR, et al. BMJ Open Sport and Exerc Med, 2016
* Data on file at DSM Biomedical. N = 60, paired analysis, samples of a 3:1 ratio of human blood to human
bone marrow aspirate. Testing conducted at BioSciences Research Associates, Inc. Cambridge, MA
Mechanical Devices
LAVA™ cell concentration technology
• Bedside concentration of autologous fluids
• 5 times faster than market leading
devices
– 60 second spin time
– Simple 3 step process
• High cell concentration with low
variability offers more predictable device
output
– 89% platelet recovery1
– 7.9X Increase over base line1
– 4.2% variance1
– 77% nucleated cell recovery*
• Lightest weight and most portable device
– 5" x 5" footprint
– Less than 4 lbs. fully loaded
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Collagen
Over 25 years of clinical use
• Best in class handling
• Customization
– Architecture
– Resorption time
– Mechanical properties
• Combination through our
bioceramic and resorbable
polymer materials portfolio to
customize scaffolds and carriers
for bone repair
• Over 25 million collagen
implants produced
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Extracellular Matrices
Over 30,000 devices implanted to date
• Superior handling options
• Published studies showing
– High retention of native molecules
– Minimal antigens
• Readily available as components and
devices
– Dermis, pericardium, and peritoneum
• Regulatory approvals and clearances
in 6 continents including nine 510(k)
clearances
• Customization based on material
selection
– Thickness, strength, and handling
properties
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ComfortCoat® Hydrophilic coatings
Industry-leading process control and optimization
• Ready to use formulations with 3 year shelf-
life
• Excellent durability
• Excellent lubricity with low friction (CoF<0.02)
• Excellent particulate performance at 7-15x
below USP-788 criteria
• No wear observed during pinch test
• Proven on wide range of substrates: Nylon,
PUR, PI, Pebax, PE, PP, PVC, Isoprene, PEEK,
FEP
• Turnkey access to design, development,
components supply and manufacturing of
coated devices
• 4 Material Master Files on file with the FDA
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Polyethylene: Dyneema Purity® UHMWPE fiber
World’s strongest and most durable medical-grade fiber
• 15x stronger than steel
• The widest range of colors and sizes
• Over 15 years clinical use enable fast
regulatory approvals in medical device
applications
• Used globally by leading medical device
companies
• Compliant with ASTM F2848-16 medical
grade UHMWPE yarn requirements
• Dedicated production plant, ISO 13485
certified
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Polyurethanes
25 years of clinical history in long-term implantable devices
• Bionate® PCU, Elasthane™ TPU, CarboSil ®
TSPCU, PurSil® TSPU, BioSpan® SPU
• Supported by 7 FDA material master files
• Tailored surface properties
• Adhesion modulation
• Hydrophobicity
• Reduced thrombus
• Increased hemocompatibility
• Lubricity
• Range of mechanical properties
– Hardness, tensile strength, elongation, flex
fatigue
• Solution & melt processing
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