This document lists 68 abstracts from published papers by R.S. Aronstam and others on research related to acetylcholine receptors and their interactions with various ligands and drugs. The abstracts cover topics such as the chemical nature of muscarinic receptors in the brain, solubilization of muscarinic receptors from bovine brain, phencyclidine interactions with nicotinic and muscarinic receptors, and regulation of muscarinic receptor binding properties. The research involved experiments using rat brain, bovine tissue, and Torpedo electric organ preparations to study acetylcholine receptor biochemistry and pharmacology.

1. ABSTRACTS
1. Aronstam, R.S., L.G. Abood and W. Hoss, The chemical nature of the muscarinic receptor in rat brain,
Trans. Am. Soc. Neurochem. 8: 129, 1977.
2. Aronstam, R.S., L.G. Abood,W. Hoss and C. Kellogg, SH reagents and heavy metals on brain muscarinic
acetylcholine receptor, Trans. Am. Soc. Neurochem. 9:122,1978.
3. Aronstam, R.S., M.E. Eldefrawi and D. Schuessler,Solubilization and partial purification of muscarinic
acetylcholine receptors from bovine brain, Fedn. Proc. 37:820,1978.
4. Tsai, M.-C., R.S. Aronstam, M.E. Eldefrawi, A.T. Eldefrawi and E.X. Albuquerque,Phencyclidine
interaction with the nicotinic acetylcholine receptor-ion channel complex and effect on potassium
conductance, Fedn.Proc. 38:258, 1979.
5. Jim, K., D. J. Triggle, E.X. Albuquerque,R.S. Aronstamand M.E. Eldefrawi, Phencyclidine interaction
with peripheral and central muscarinic receptors, Fedn. Proc. 38:257, 1979.
6. Aronstam, R.S. and M.E. Eldefrawi, Reversible conversion between agonist affinity states ofthe
muscarinic acetylcholine receptor from rat brain, Fedn. Proc. 38:273, 1979.
7. Spivak, C.E., E.X. Albuquerque,R.S. Aronstamand M.E. Eldefrawi, A study of pre- and post-synaptic
reactions of a potent agonist of the nicotinic receptor, Soc. Neurosci. Abstr. 5:489, 1979.
8. Salem, N. and R.S. Aronstam, Chemical modification of brain muscarinic acetylcholine receptors, Trans.
Am. Soc. Neurochem. 11:192, 1980.
9. Buccafusco, J.J. and R.S. Aronstam, Cholinergic actions of acetylpyrrolidinecholine, a false
neurotransmitter, Soc. Neurosci. Abstr. 6:150, 1980.
10. McKay, D.B., G.O. Carrier and R.S. Aronstam, Influence of calcium on the ion channelassociated with
the nicotinic acetylcholine receptor, Soc. Neurosci Abstr. 6:298, 1980.
11. Aronstam, R.S., Cholinergic actions of anatoxin-a, Pharmacologist 22:300, 1980.
12. Carrier, G.O. and R.S. Aronstam, Comparison of histrionicotoxin and phencyclidine binding sites on the
ion channel of the nicotinic acetylcholine receptor, Pharmacologist 22:181, 1980.
13. Aronstam, R.S. and A.R. Blount, Jr., Cholinergic actions of tricyclic antidepressants, Trans.SE
Pharmacol. Soc. 1:26, 1980.
14. Edwards, A.D. and R.S. Aronstam, Regulation of agonist binding properties of muscarinic acetylcholine
receptors from rat brain, Fedn. Proc. 40:310, 1981.
15. Aronstam, R.S., Influence of pH on the interactions of drugs with the nicotinic receptor-ion channel
complex, Soc. Neurosci.Abstr. 7:700, 1981.
16. Carrier, G.O. and R.S. Aronstam, Muscarinic receptor regulatory mechanisms in membrane-bound and
detergent-solubilized preparations, Soc.Neurosci.Abstr.7:498, 1981.
17. Narayanan, L. and R.S. Aronstam, Biochemical characterization of ketamine interactions with the
nicotinic receptor-ion channelcomplex, Soc. Neurosci Abstr. 7:806, 1981.
18. Carrier, G.O. and R.S. Aronstam, Influence of N-ethylmaleimide on muscarinic receptors and responses in
guinea pig ileum, Trans. SE Pharmacol. Soc. 2:17, 1981.

2. 19. Buccafusco, J.J. and R.S. Aronstam, Acetyldiethylcholine: Cholinergic actions of a false
neurotransmitter, Trans. SE Pharmacol. Soc. 2: 17, 1981.
20. Aronstam, R.S., D.C. Marshall and J.J. Buccafusco, Biochemical and physiological activity of
acetylmonoethylcholine, Fedn. Proc. 41: 1308, 1982.
21. Carrier, G.O. and R.S. Aronstam, Regulation of muscarinic responses and receptors in guinea pig ileum by
N-ethylmaleimide, Fedn. Proc. 41: 1321, 1982.
22. Narayanan, L. and R.S. Aronstam, Phencyclidine inhibition of ligand binding to the nicotinic receptor-ion
channel complex, Fedn. Proc. 41: 1332, 1982.
23. Aronstam, R.S. Aminopyridine interactions with acetylcholine receptor complexes at nicotinic synapses,
Soc. Neurosci. Abstr. 8: 500, 1982.
24. Graham, J.L., L. Narayanan and R.S. Aronstam, Quinuclidinyl benzilate actions at nicotinic cholinergic
synapses: Biochemical characterization, Soc. Neurosci. Abstr. 8: 500, 1982.
25. Wenger, D.A. and R.S. Aronstam, Muscarinic acetylcholine receptor regulation in brain: Influence of
solubilization, Trans. SE Pharmacol. Soc. 3: 21, 1982.
26. Marshall, D.C., R.S. Aronstamand G.O. Carrier, Calcium fluxes induced by barium and muscarinic
agonists in guinea pig ileum: Influence of alkylation, Trans. SE Pharmacol. Soc. 3: 19, 1982.
27. Wenger, D.A. and R.S. Aronstam, Heterogeneity of muscarinic acetylcholine receptors: Influence of
solubilization, Proc. Soc. Exp. Biol. Med. 172: 126, 1983.
28. Marshall, D.C., J.J. Buccafusco and R.S. Aronstam, Biochemical and physiological activity of
acetylcholine analogues, Trans. SE Pharmacol. Soc. 3: 19, 1982.
29. Ikeda, S.R., R.S. Aronstamand E.X. Albuquerque,Interactions of bupivicaine with the ionic channels of
nicotinic receptors, Soc.Neurosci. Abstr. 8: 499, 1982.
30. Marshall, D.C., R.S. Aronstamand G.O. Carrier, Muscarinic agonists and barium-induced 45calcium
influx in guinea pig ileum, Fedn. Proc. 42:1146, 1983.
31. Carrier, G.O., A.D. Edwards and R.S. Aronstam, Increased cholinergic sensitivity of hearts from diabetic
rats, J. Molec. Cell.Cardiol. in press.
32. Aronstam, R.S. and M.L. Kirby, Atropine-induced alterations of normal development of muscarinic
receptors in embryonic chick heart, Pharmacologist 25: 184, 1983.
33. Carrier, G.O., A.D. Edwards and R.S. Aronstam, Diabetes-induced cholinergic super-sensitivity of rat
heart, Pharmacologist 25: 238, 1983.
34. Hoss,W. and R.S. Aronstam, Drug inhibition of calcium uptake by rat brain synaptosomes, Soc.Neurosci.
Abstr. 9: 501, 1983.
35. King, C.T. and R.S. Aronstam, Benzomorphan interactions with acetylcholine receptor-ion channel
complexes from Torpedo, California, Soc. Neurosci. Abstr. 9: 579, 1983.
36. Kirby, M.L., R.S. Aronstamand J.J. Buccafusco, Neural influences on muscarinic acetylcholine receptors
in developing chick heart, Soc. Neurosci. Abstr. 9: 936, 1983.
37. Stewart, D.E., M.L. Kirby and R.S. Aronstam, Beta-adrenergic receptors in developing chick hearts and
effects of 6-hydroxydopamine, J. Cell. Biol. 97: 467, 1984.

3. 38. McKay, D.B., R.S. Aronstamand A.S. Schneider, Interaction of microtubule-active drugs with the
Torpedo nicotinic receptor: Correlations with effects on adrenal catecholamine secretion and 45Ca uptake,
Fedn. Proc. 43: 467, 1984.
39. Carrier, G.O., A.D. Edwards, R.E. White and R.S. Aronstam, Diabetes-induced cardiac muscarinic
supersensitivity,Soc.Neurosci. Abstr. 10: 605, 1984.
40. Parthasarathy,N. and R.S. Aronstam, Alterations of muscarinic acetylcholine receptor binding in rat brain
by phospholipase C action, Soc. Neurosci. Abstr. 10: 566, 1984.
41. Aronstam, R.S. and L.M. Greenbaum, Elimination of guanine nucleotide sensitivity of muscarinic
acetylcholine receptors from rat brainstem by endogenous proteolytic activity, Soc. Neurosci. Abstr. 10: 670,
1985.
42. Eason, K.E. and R.S. Aronstam, Potassium-stimulated calcium uptake by rat brain synaptosomes:
Inhibition by sulfhydryl reagents, Soc. Neurosci. Abstr. 10: 869, 1984.
43. Anthony,B.L. and R.S. Aronstam, Influence of pH on muscarinic acetylcholine receptors from rat
brainstem, Trans. SE Pharmacol. Soc. 5:29, 1984.
44. Eason, K.E. and R.S. Aronstam, Depolarization-induced calcium uptake by rat brain synaptosomes is
inhibited by heavy metals and sulfhydryl reagents, Trans, SE Pharmacol. Soc. 5: 30, 1984.
45. Kirby, M.L., R.S. Aronstamand J.J. Buccafusco, Decreases in cardiac ganglion cells,acetylcholine, and
muscarinic receptors associated with conotruncal malformations in chick embryos, Circulation,1984.
46. Catravas, J.D., R.S. Aronstamand U.S. Ryan, Muscarinic binding and acetylcholine-induced reduction in
thromboxane B2 release by cultured bovine pulmonary arterial endothelial cells, Fedn. Proc. 44: 1843, 1985.
47. Narayanan, L., R.S. Aronstam, E.X. Albuquerque and J.W. Daly, Gephyrotoxin interaction with
histrionicotoxin binding sites on the nicotinic acetylcholine receptor complex of Torpedo electric organ, Soc.
Neurosci. Abstr. 11: 595, 1985.
48. Aronstam, R.S. and J.J. Buccafusco,Clonidine protection from the toxicity of peripherally and centrally
active acetylcholinesterase inhibitors, Soc. Neurosci.Abstr. 11: 993, 1985.
49. Dennison, R.L., B.L. Anthony,G.O. Carrier and R.S. Aronstam, Influence of halothane on muscarinic
acetylcholine receptor binding and interactions with GTP-dependent regulatory proteins, Soc. Neurosci.
Abstr. 11: 95, 1985.
50. Carrier, G.O. and R.S. Aronstam, Parasympathetic regulation of the heart in diabetes, Soc. Neurosci.
Abstr. 11: 1153, 1985.
51. Buccafusco, J.J. and R.S. Aronstam, Stimulation of central adrenergic receptors reduces cholinesterase
inhibitor toxicity in mice, Soc. Neurosci.Abstr. 11: 1995, 1985.
52. Dennison, R.L., B.L. Anthony and R.S. Aronstam, Halothane and brain muscarinic receptors:Alteration of
ligand binding and G protein interactions, Anesthesiol. Abstr. 63: 3A, 1985.
53. Aronstam, R.S. and J.J. Buccafusco,Comparison of the toxic manifestations of soman (GD)and
echothiophate (EC) in mice, and the protection afforded by clonidine, Proceedings,Fifth Annual Chemical
Defense Bioscience Review, 1985.
54. Buccafusco, J.J. and R.S. Aronstam, Protection against soman (GD) toxicity by clonidine in mice,
Proceedings, Fifth Annual Chemical Defense Bioscience Review, 1985.

4. 55. Anthony,B.L. and R.S. Aronstam, Disruption of muscarinic receptor-G protein interactions at low pH,
Pharmacologist 27: 133, 1985.
56. Carrier, G.O. and R.S. Aronstam, Altered parasympathetic activity in diabetes, Pharmacologist 27: 137,
1985.
57. Buccafusco, J.J. and R.S. Aronstam, Inhibition of central cholinergic cardiovascular neurons by choline
analogs,Pharmacologist 27:137, 1985.
58. McKay, D.B., M.J. Cobianchi, R.S. Aronstamand A.S. Schneider, Do the anticholinergic actions of
colchicine involve microtubules? Pharmacologist 27: 136, 1985.
59. Aronstam, R.S., B.L. Anthony and G.O. Carrier, Differential inactivation of muscarinic receptor-G protein
interactions in rat brainstems by physical and enzymatic means, (Second Symposium on Subtypes of
Muscarinic Receptors) Trends Pharmacol. Sci. 7S: 78, 1986.
60. Swanson, K.L., C.N. Allen, R.S. Aronstamand E.X. Albuquerque, Characteristics of acetylcholine
receptor-ionic channels (AChR) activated by the secondary amine (+)anatoxin, Soc. Neurosci.Abstr. 11: 94,
1985.
61. Aronstam, R.S., J.D. Catravas and U.S. Ryan, Muscarinic binding sites in cultured bovine arterial
endothelial cells, Fedn. Proc. 45: 554, 1986.
62. Narayanan, T.K., R.S. Aronstam, E.X. Albuquerque and J.W. Daly, Interaction of piperidine derivatives
with the nicotinic cholinergic receptor from Torpedo electric organ, Soc. Neurosci. Abstr. 12: 1076, 1986.
63. Aronstam, R.S. and T.K. Narayanan, Gallamine regulation of muscarinic receptor binding: Influence of
guanine nucleotides and conformational state, Soc. Neurosci. Abstr. 12: 492, 1986.
64. Anthony,B.L. and R.S. Aronstam, High affinity agonist binding to brainstem muscarinic receptor is
eliminated by low pH, Soc. Neurosci.Abstr. 12: 816, 1986.
65. Dennison, R.L., B.L. Anthony and R.S. Aronstam, Muscarinic receptor coupling to G proteins in rat heart
is altered by volatile anesthetics, Soc.Neurosci. Abstr. 12: 1078, 1986.
66. Aronstam, R.S. and J.J. Buccafusco,Multiple actions of clonidine in protecting mice from soman
poisoning,Pharmacologist 28: 132, 1986.
67. Narayanan, T.K. and R.S. Aronstam, Allosteric regulation of different species of muscarinic receptor,
Pharmacologist 28: 130, 1986.
68. Dennison, R.L., R.S. Aronstamand B.L. Anthony,Halothane and enflurane interfere with muscarinic
receptor-G protein interactions in rat heart, Pharmacologist 28: 158, 1986.
69. Carrier, G.O. and R.S. Aronstam, Enhanced cardiac muscarinic receptor activity in diabetes,
Pharmacologist 28: 157, 1986.
70. Buccafusco, J.J., J.H. Graham and R.S. Aronstam, Inhibition of soman-induced behavioral changes in the
rat by atropine and clonidine, Pharmacologist 28: 225, 1986.
71. Anthony,B.L., R.L. Dennison and R.S. Aronstam, Volatile anesthetics interfere with muscarinic receptor-
G protein interactions in rat heart, Trans. SE Pharmacol. Soc. 7:12, 1986.
72. Buccafusco, J.J. and R.S. Aronstam, Clonidine prevents short-term, soman-induced down regulation of
muscarinic receptors in mouse brain, Fedn. Proc. 46: 1464, 1987.

5. 73. Aronstam, R.S. and T.K. Narayanan, Influence of temperature on the demonstration of muscarinic
receptor G protein interactions in mouse brain, Fedn. Proc. 46: 703, 1987.
74. Legrand, A.B., T.K. Narayanan, R.S. Aronstam, U.S. Ryan and J.D. Catravas, Adenylate cyclase activity
in membranes from cultured bovine aortic and pulmonary arterial endothelial cells, Fedn. Proc. 46: 1111,
1987.
75. Magri, V., R.S. Aronstamand J.J. Buccafusco, Effect of clonidine on the cardiovascular changes induced
by soman, a centrally active irreversible cholinesterase inhibitor, Fedn. Proc. 46: 690, 1987.
76. Van Lingen, J.C., R.S. Aronstam, J.H. Graham and J.J. Buccafusco, Protection by clonidine and atropine
of the acute and chronic behavioral changes induced by cholinesterase inhibitor toxicity, Fedn. Proc. 46: 859,
1987.
77. Narayanan, T.K., R.L. Dennison,B.L. Anthony and R.S. Aronstam, Halothane depresses the guanine
nucleotide sensitivity of high affinity agonist binding to cardiac muscarinic receptors in rat heart, Fedn. Proc.
46: 703, 1987.
78. Aracava, Y., K.L. Swanson,H. Rapoport, R.S. Aronstamand E.X. Albuquerque,Anatoxin-analog: Loss
of nicotinic agonism and gain of antagonismat the acetylcholine-activated channels, Fedn. Proc. 46: 861,
1987.
79. Dennison, R.L., B.L. Anthony and R.S. Aronstam, Ether disrupts muscarinic acetylcholine receptor-G
protein interactions in rat brain, Pharmacologist 29: 172, 1987.
80. Narayanan, T.K., R.L. Dennison and R.S. Aronstam, Halothane inhibits muscarinic control of adenylate
cyclase activity in rat heart, Pharmacologist 29: 181, 1987.
81. Carrier, G.O. and R.S. Aronstam, Insulin prevents diabetes-induced muscarinic supersensitivity and
decrease in receptor density in right atrium of rats, Pharmacologist 29: 196, 1987.
82. Makari, N.F., R.S. Aronstamand J.J. Buccafusco, Enhanced binding of [3H]hemicholinium-3 to
membranes prepared from several brain regions of spontaneously hypertensive rats, Soc.Neurosci. Abstr. 13:
745, 1987.
83. Anthony,B.L. and R.S. Aronstam, Volatile anesthetics interfere with muscarinic receptor-G protein
interactions in rat heart, Georgia J. Sci. 45: 95, 1987.
84. Carrier, G.O. and R.S. Aronstam, Abnormal cardiac muscarinic activity in diabetes, J. Med. Assoc. GA 76:
585, 1987.
85. Dennison, R.L., B.L. Anthony and R.S. Aronstam, Volatile anesthetics disrupt muscarinic receptor-G
protein coupling in rat heart, J. Med. Assoc. GA 76: 648, 1987.
86. Christiansen, J.L., W. Covitz, H.V. Moore and R.S. Aronstam, Cardiac muscarinic receptors in
conotruncalabnormalities, Clin.Res. 35: 50A, 1987.
87. Aronstam, R.S. and T.K. Narayanan, Acetylcholine stimulated GTPase activity in rat striatal membranes:
Inhibition by a volatile anesthetic, FASEB J. 2: A612, 1988.
88. Anthony,B.L., R.L. Dennison, T.K. Narayanan and R.S. Aronstam, Volatile anesthetics inhibit
muscarinic modulation of adenylate cyclase in rat heart, FASEB J. 2: 1395, 1988.
89. Baumgartner, M.K., R.L. Dennison and R.S. Aronstam, Halothane depresses the guanine nucleotide
sensitivity of clonidine binding to alpha2-adrenergic receptors in rat brain, FASEB J. 2: A1139, 1988.

6. 90. Carrier, G.O. and R.S. Aronstam, Muscarinic supersensitivity of rat heart in diabetes: Effect of insulin
treatment and role of receptor-G protein coupling, FASEB J. 2:A1594, 1988.
91. Narayanan, T.K., G.O. Carrier and R.S. Aronstam, Adenylate cyclase activity in rat heart in streptozotocin
diabetes: Altered basal activity and control by autonomic receptors and guanine nucleotides, FASEB J.
2:A1594, 1988.
92. Legrand, A.B., T.K. Narayanan, U.S. Ryan, R.S. Aronstamand J.D. Catravas, Cholinergic modulation of
cAMP levels in cultured bovine pulmonary arterial endothelial cells, FASEB J. 2:A297, 1988.
93. Swanson, K.L., R.S. Aronstam, H. Rapoport, F.J. Sardina and E.X. Albuquerque, Structure-activity
relationships of anatoxin analogs at the nicotinic acetylcholine receptor (AChR), Soc. Neurosci. Abstr.
14:1327, 1988.
94. Anthony,B.L., R.L. Dennison, T.K. Narayanan and R.S. Aronstam, Halothane inhibition of acetylcholine-
stimulated pertussis toxin-sensitive GTPase activity in rat brain, Soc. Neurosci. Abstr. 14:811, 1988.
95. Narayanan, T.K. and R.S. Aronstam, GDP release from rat synaptic membranes is stimulated by receptors
linked to both activation and inhibition of adenylate cyclase, Soc. Neurosci. Abstr. 14:281, 1988.
96. Aronstam, R.S. and T.K. Narayanan, Influence of ethanolon muscarinic receptor-G protein interactions in
rat brainstem, Soc. Neurosci.Abstr. 14:811, 1988.
97. Dennison, R.L., W. Boswell, N. Harmer, E. Wright, T.K. Narayanan and R.S. Aronstam, Selective
inactivation of G proteins associated with muscarinic receptors by heat, Soc. Neurosci. Abstr. 14:228, 1988.
98. Spivak, C.E., J.A. Waters and R.S. Aronstam, Binding of the highly potent nicotinic agonist,isoarecoline
methiodide, and 19 of its analogues at nicotinic and muscarinic receptors, Soc. Neurosci. Abstr. 14:506, 1988.
99. Catravas, J.D., R.S. Aronstamand U.S. Ryan, Muscarinic binding sites in cultured rabbit pulmonary
arterial endothelial cells, FASEB J. 3:A1308, 1989.
100. Aronstam, R.S., L. Narayanan, R.L. Dennison, R. Ravindra and T.K. Narayanan, Influence of ethanolon
muscarinic receptor-stimulated G Protein GTPase Activity in Rat Brainstem, FASEB J. 3:A1294, 1989.
101. Ravindra, R., R.L. Dennison,T.K. Narayanan and R.S. Aronstam, Influence of colchicine on the basal and
receptor-stimulated GTPase activity of G proteins in rat striatum, FASEB J. 3:A1293, 1989.
102. Narayanan, T.K. and R.S. Aronstam, Altered G protein function in spontaneously hypertensive rats, FASEB
J. 3:A1028, 1989.
103. Ravindra, R., R.L. Dennison,T.K. Narayanan and R.S. Aronstam, Possible involvement of tubulin in G
protein function and coupling to muscarinic receptors in rat striatum, Endocrinology,1989.
104. Buccafusco, J.J. and R.S. Aronstam, Effect of addition of clonidine to standard pretreatment regimens against
the acute and chronic toxicity of soman, Proceedings, Ninth AnnualChemical Defense Bioscience Review,
1989.
105. Wonnacott,S., S. Jackman, V.B. Cockcroft, R.S. Aronstam, H. Rapoport, K.L. Swanson and E.X.
Albuquerque,Interactions of anatoxin-a analogues with neuronal acetylcholine receptors, Soc. Neurosci.
Abstr. 15:678, 1989.
106. Swanson, K.L., R.S. Aronstam, S. Wonnacott,H. Rapoport and E.X. Albuquerque,Nicotinic potency of
anatoxin analogues with modificiations of the acetyl moiety, Soc. Neurosci. Abstr. 15:557, 1989.

7. 107. Ravindra, R. and R.S. Aronstam, Modulation of muscarinic receptor-stimulated G protein GTPase activity by
tubulin in rat striatum, Trans. SE Pharmacol. Soc. 10:25, 1989.
108. Aronstam, R.S., R. Ravindra and Hylan Shoob, Lithium does not interfere with muscarinic acetylcholine
receptor-G protein interactions in rat striatum, Trans. SE Pharmacol. Soc. 10:31, 1989.
109. Narayanan, T.K. and R.S. Aronstam, Altered G protein functions in spontaneously hypertensive rats, Trans.
SE Pharmacol. Soc. 10:34, 1989.
110. Dennison, R.L. and R.S. Aronstam, Halothane disrupts muscarinic receptor-mediated stimulation of G protein
GTPase activity, Trans. SE Pharmacol. Soc. 10:33, 1989.
111. Yang, X., R.S. Aronstamand R.L. Dennison, Ethanol attenuates guanine nucleotide inhibition of of high
affinity oxotremorine binding in rat brain, Trans. SE Pharmacol. Soc. 10:32, 1989.
112. Buccafusco, J.J. and R.S. Aronstam, Long-term behavioral abnormalities produced by the irreversible
cholinesterase inhibitor soman: Effect of a standard pretreatment regimen and clonidine, Trans. SE.
Pharmacol. Soc. 10:57, 1989.
113. Ravindra, R. and R.S. Aronstam, GnRH regulation of G protein function in the rat anterior pituitary lobe, SE
Endocrine Soc., 1989.
114. Martin, D.C., R.P. Introna and R.S. Aronstam, The effects of halothane and sufentenil on synaptic activity of
5-hydroxytryptamine, FASEB J. 4:A324, 1990.
115. Carrier, G.O. and R.S. Aronstam, Muscarinic receptor activity in ileal smooth muscle is enhanced in diabetes,
FASEB J. 4:A1012, 1990.
116. R. Ravindra and R.S. Aronstam, Modulation of muscarinic receptor-stimulated G protein GTPase activity by
tubulin in rat striatum, FASEB J. 4:A1011, 1990.
117. Dennison, R.L., R. Ravindra, H. Shoob and R.S. Aronstam, Lithium does not interfere with muscarinic
acetylcholine receptor-G protein interactions in rat striatum, FASEB J. 4:A1118, 1990.
118. Silveira, F.C.A., M.E. Nelson, K.-P. Shaw, R.S. Aronstamand E.X. Albuquerque,A study of acridine
analogs on nicotinic receptors, FASEB J. 4:A471, 1990.
119. Marczin, N., R.S. Aronstam, U.S. Ryan and J.D. Catravas, Differences in the cholinergic modulation of
cAMP accumulation among vascular cells in culture, FASEB J. 4:A835, 1990.
120. Ravindra, R. and R.S. Aronstam, Influence of anti-tubulin antibodies on muscarinic receptor modulation of G
protein GTPase activity in rat striatum, Endocrinology Society Abstracts 295, 1990.
121. Ravindra, R. and R.S Aronstam, Possible role of tubulin in GnRH receptor-G protein coupling in the rat
anterior pituitary lobe, Soc. Neurosci. Abstr. 16:393, 1990.
122 . Martin, D.C. and R.S. Aronstam, The volatile anesthetic,enflurane, disrupts glutamate-stimulated
[3H]MK-801 binding in rat brain, Soc. Neurosci. Abstr. 16:376, 1990.
123. Holland, L.N., B.D. Goldstein and R.S. Aronstam, Substance P receptor desensitization: Involvement of a
GTP binding protein, Soc. Neurosci. Abstr. 16:515, 1990.
124. Shaw, K.P., F.C.A. Silveira, R.S. Aronstamand E.X. Albuquerque,A new class of cholinergic
antagonists: Acridine araphanes have a high affinity to muscarinic receptors, Soc. Neurosci.Abstr. 16:1060,
1990.

8. 125. Martin, D.C. and R.S. Aronstam, The volatile anesthetic,enflurane, disrupts glutamate-stimulated [3H]MK-
801 binding in rat brain, Workshop,Subcellular Mechanisms of Anesthetic Action in Muscle, Baltimore,
MD, 1990.
126. Tano, T., K. Rice, R.S. Aronstam, A.C. Oliveira, Y. Aracava and E.X. Albuquerque,Effect of metaphit on the
peripheral nicotinic acetylcholine (ACh) receptor, Soc. Neurosci.Abstr. 16:207, 1990.
127. Lewis, D.L., R.S. Aronstamand S.R. Ikeda, Expression of an inwardly rectifying K+ channel from RBL-2H3
cells in Xenopus oocytes,Biophys.J 59:451a, 1991.
128. Holland, L.N., B.D. Goldstein and R.S. Aronstam, A guanine nucleotide decreases substance Preceptor
binding in rat dorsal horn membranes, Proc. Soc. Exptl.Biol. Med., 1991.
129. Martin, D.C. and R.S. Aronstam, Anesthetic disruption of neurotransmission at NMDA receptors, Trans. Am.
Soc. Neurochem.22:215, 1991.
130. Martin, D.C. and R.S. Aronstam, Concentrations of volatile anesthetics in vitro assays,FASEB J 5:A868,
1991.
131. Fender, M.W., D.C. Martin and R.S. Aronstam, The effects of pentobarbital on NMDA receptors, FASEB J
5:A854, 1991.
132. Aronstam, R.S. and D.C. Martin, Inhibition of glutamate-stimulated [3H]MK-801 binding is a general
property of volatile anesthetics, FASEB J 5:A408, 1991.
133. Ravindra, R. and R.S. Aronstam, Thyrotropin releasing hormone (TRH) receptor-G protein interactions in the
rat anterior pituitary lobe are disrupted by colchicine and taxol, FASEB J 5:A1498, 1991.
134. Baumgartner, M.K. and R.S. Aronstam, Influence of differentiation on muscarinic receptor systems in
neuronal cells, FASEB J 5:A856, 1991.
135. Ravindra, R. and R.S. Aronstam, Estradiol-
protein GTPase activity in rat anterior pituitary lobe, Endocrinology Society Abstracts,1991.
136. Aronstam, R.S., R.L. Dennison, R. Ravindra and D.C. Martin, Ethanol disruption of muscarinic acetylcholine
receptor-stimulated G protein GTPase activity and guanine nucleotide binding in rat brain, Alcoholism: Clin.
Exp. Research 15:328, 1991.
137. Martin, D.C., R.L. Dennison, M.K. Baumgartner and R.S. Aronstam, Influence of volatile anesthetics on
NMDA-stimulated 45Ca uptake in rat brain, Soc. Neurosci.Abstr. 17:, 1991.
138. Baumgartner, M.K., D.C. Martin, R.L. Dennison and R.S. Aronstam, Influence of retinoic acid-induced
differentiation on NMDA receptors in cultured Neuro-2A cells, Soc. Neurosci. Abstr. 17:, 1991.
139. Ravindra, R. and R.S. Aronstam, Stimulation of [32P]GDP release from G proteins in the rat anterior
pituitary lobe by gonadotropin-releasing hormone, Soc. Neurosci. Abstr. 17:, 1991.
140. Tano, T., A. Maelicke, R.S. Aronstamand E.X. Albuquerque, Benzoquinonium (BZQ) interactions with
peripheral nicotinic acetylcholine receptors (AChR): Electrophysiological and biochemical studies, Soc.
Neurosci. Abstr. 17:1527, 1991.
141. Shaw, K.P., S. Pou, R.S. Aronstamand E.X. Albuquerque,Acridine araphanes: A new class of drugs used to
evaluate pharmacophore interactions with cholinergic receptors, Soc. Neurosci. Abstr. 17:, 1991.

9. 142. Ravindra, R. and R.S. Aronstam, Estradiol- testosterone inhibit thyrotropin releasing
hormone stimulation of G protein GTPase activity in rat anterior pituitary lobe, Endocrinology Society
Abstracts, 1992.
143. Baumgartner, M.K., J.Wei and R.S. Aronstam, Muscarinic receptor expression after differentiation in human
neuroblastoma cells, Pharmacologist 34:186, 1992.
144. Martin, D.C., R.L. Dennison and R.S. Aronstam, Characterization of volatile anesthetic interactions with
NMDA receptors, Trans. SE Pharmacol. Soc.13:39, 1992.
145. Baumgartner, M.K. and R.S. Aronstam, Differentiation induced by retinoic acid alters G protein GTPase
and adenylate cyclase activities in a human neuroblastoma cell line, Trans. SE Pharmacol. Soc 13:38, 1992.
146. Wei, J., D.C. Hess,J.D. Catravas and R.S. Aronstam, Microvascular endothelial cells from human
cerebral cortex express only the m2 subtype of muscarinic receptor, Trans. SE Pharmacol. Soc 13:43, 1992.
147. Aronstam, R.S., R.L. Dennison,and D.C. Martin, Ethanol inhibition of muscarinic receptor-stimulated
binding of guanine nucleotides to G proteins in membranes from rat striatum, Alcoholism: Clin.Exp.
Research 17:499, 1993.
148. Aronstam, R.S. and T.L. Creazzo, Neurotransmitter stimulation of G protein GTPase activity in developing
chick heart, Soc.Neurosci. Abstr. 19:1094, 1993.
149. Martin, D.C., R.L. Dennison and R.S. Aronstam, Enflurane inhibition of glutamate-stimulated [3H]MK-
801 binding is attenuated by spremidine, Soc. Neurosci. Abstr. 19:1784, 1993.
150. Aronstam, R.S., H.L. Puhl, R.L. Dennison and D.C. Martin, Spermidine attenuates volatile anesthetic-
induced disruption of glutamate-sensitive [3H]MK-801 binding, FASEB J 9:A393, 1995.
151. H. Puhl, C.L. Williams, D.C. Martin, R.L. Dennison and R.S. Aronstam, Muscarinic receptor-mediated
increases in the intracellular calcium concentration of neuroblastoma cells are inhibited by the protein kinase
inhibitor, KN-62, FASEB J. 9:A389, 1995.
152. Martin D.C., R.S. Williams and R.S. Aronstam, Volatile anesthetics disrupt nitrous oxide analgesia in the
fomalin test in the rat, FASEB J. 9:A393, 1995.
153. Aronstam, R.S., B.L. Mahon,E. Choi and H.L. Puhl, M1 and m5 muscarinic acetylcholine receptors
expressed in CHO cells stimulate different signal transduction pathways, Mol Biol Cell 6:212a, 1995.
154. Aronstam, R.S., B.L. Mahon,E. Choi and H.L. Puhl, M1 and M5 muscarinic acetylcholine receptors
expressed in CHO cells stimulate different signal transduction pathways,Ross PosterSession,SUNY Health
Science Center, Syracuse, 1995.
155. Puhl, H.L., J.D. Noti, T. Shay, J. Mattison and R.S. Aronstam, Analysis of the promoter regionof the gene
for the human m3 muscarinic acetylcholine receptor, FASEB J. 10:A404, 1996.
156. Stair, S., C.L. Williams, H.L. Puhl, L.G. May and R.S. Aronstam, Influence of acute and chronic ethanol
exposure on arachidonic acid release mediated by muscarinic acetylcholine receptors expressed in CHO cells,
Soc. Neurosci. Abstr. 22:1758, 1996.
157. Canney D., J. Buccafusco,R. Aronstam, M. Gattu, M. Zhang,G. Sterling and P. Doukas, Preliminary
characterization of ethyl(3-quinuclidinyl)acetate as a novel acetylcholine receptor ligand, Soc. Neurosci.
Abstr. 22:1262, 1996.
158. May L.G., H.L. Puhl, C.L. Williams and R.S. Aronstam, Arachidonic acid release mediated by muscarinic
acetylcholine receptor subtypes expressed in CHO cells, Mol Biol Cell 7:175a, 1996.

10. 159. Chang, Z.L., L.G. May, H.L. Puhl, J. Mattison and R.S. Aronstam, Influence of acute and chronic ethanol
treatment on muscarinic responses and receptorexpression in CHO cells, Mol Biol Cell 7:648a, 1996.
160. Aronstam, R.S., H.L. Puhl, L.G. May, Ethanol alteration of muscarinic receptor control of adenylate cyclase
activity in rat brainstem, Soc. Neurosci.Abstr. 23:2019, 1997.
161. Puhl, H.L., T. Shay, L.G. May and R.S. Aronstam, Influence of chronic ethanoltreatment on the expression
of G proteins in six regions of rat brain, Soc. Neurosci. Abstr. 23:2044, 1997.
162.Williams, C.L., L.G. May, S. Krebs, A. Newman, R.S. Aronstam, Differential involvement of protein kinase
C and protein kinase A in the muscarinic receptor signaling pathways mediating arachidonic acid release and
PLC activation, Soc. Neurosci. Abstr. 23:710, 1997.
163.May, L.G., N. Khosa,H.L. Puhl, R.S. Aronstam, Muscarinic acetylcholine receptor stimulation of
phospholipase D, Soc. Neurosci. Abstr. 23:1749, 1997.
164.Aronstam, R.S., L.G. May, V. Chandrasekaran, Z.L. Chang, S.M. Stair and C.L. Williams, Muscarinic
receptor-mediated stimulation of phospholipase C and arachidonic acid release, but not calcium mobilization ,
is disrupted by chronic exposure to ethanol, Molec. Biol. Cell 8:4447a, 1997.
165.May, L.G., C.L. Williams and R.S. Aronstam, G-Protein involvement in muscarinic acetylcholine receptor
stimulation of phospholipase D, Molec. Biol. Cell 8:143a, 1997.
166.Jeong, S.W., R.S. Aronstam, S.R. Ikeda, Pertussis toxin- reconstitute
voltage-dependent inhibition of calcium currents in rat sympathetic neurons, Soc. Neurosci. Abstr. 24:1574,
1998.
167.May, L.G., C. Bohenick, R.S. Aronstam, The role of rho in release of arachidonic acid by the muscarinic
acetylcholine receptors, Soc. Neurosci. Abstr. 24:1583, 1998.
168.Puhl, H.L., J.D. Noti, R.S. Aronstam, Analysis of the promoter region of the human M3 muscarinic
acetylcholine receptor gene, Soc. Neurosci. Abstr. 24:1586, 1998.
169.Puhl, H.L. and R.S. Aronstam, Identification of promoter activity in the gene for the human M3 muscarinic
receptors, Soc.Neurosci. Abstr. 25:1723, 1999.
170.Aronstam, R.S., A. Morelli, C.L. Williams and H.L. Puhl, Activated Rho-A does not affect M3 muscarinic
signaling pathways regulating adenylate cyclase activity, Soc. Neurosci. Abstr. 25:1984, 1999.
171.Puhl, H.L., K. Kissel, J. Mattison and R.S. AronstamIdentification of a repressorregion in the promoter of
the gene for the human m3 muscarinic acetylcholine receptor, Soc. Neurosci. Abstr. 26:125, 2000.
172.Aronstam, R.S., D.M. Lam, T. Shay and H.L. Puhl, M3 muscarinic acetylcholine receptor activation of cyclic
nucleotide signaling: role of calcium and protein kinase C, Soc. Neurosci.Abstr. 26:1644, 2000.
173.Aronstam, R.S., D.M. Lam, T. Shay and H.L. Puhl, Calcium and protein kinase c do not contribute to m3
muscarinic acetylcholine receptor activation of adenylate cyclase, Guthrie Journal 70: 38, 2001.
174.Puhl, H.L., K. Kissel, J. Mattison and R.S. Aronstam, Repressor region in the promoter of the gene for the
human m3 muscarinic acetylcholine receptor, Guthrie Journal 70: 49, 2001.
175.Ikeda, S.R., M.M. King, R.S. Aronstamand H.L. Puhl, Cloning and expression of cDNA encoding a
tetrodotoxin-resistant (TTX-R) sodium channel(Scn10a) from mouse dorsal ganglion neurons, FASEB J.
2001.

11. 176.Puhl, H.L., K. Kissel, J.C. Mattison,C.L. Williams and R.S. Aronstam, Localization of a repressorregion to
the 3’ end of the promoter of the gene for the human M3 muscarinic acetylcholine receptor, FASEB J. 2001.
177.Puhl, H.L., M.M. King, R.S. Aronstamand S.R. Ikeda, Cloning and functional characterization of a mouse
cDNA encoding a tetrodotoxin-resistant (TTX-R) sodiumchannel (SCN10A), Soc. Neurosci. Abstr., 2001.
178.Aronstam, R.S., S.R. Ikeda, S. Dugan, S. Kopatz, C. Warren and H.L. Puhl, Establishment of a Resource
Center for cDNA Clones at the Guthrie Research Institute, Guthrie Journal 71:21, 2002.
179.Puhl, H.L., K. Kissel, J.C. Mattison and R.S. Aronstam, Localization of a repressor region to the 3’ end of the
promoter of the gene for the human M3 muscarinic acetylcholine receptor, Guthrie Journal 71:32-33, 2002.
180.Freije, J.E. and R.S. Aronstam, Physician participation in clinical research in a multispecialty clinic, Guthrie
Journal 72:47, 2003.
181.Sharma, S., R.S. Aronstam, S. Kopatz and C. Warren, Establishment of a Resource Center for cDNA Clones
for signal transduction proteins, Guthrie Journal 72:59, 2003.
182.Aronstam, R.S., Guthrie Research Institute – Signal transduction research and resources.Destination
Discovery Conference: Collaborations, Binghamton, University, March, 2003.
183.Sharma, S., R.S. Aronstam, S. Kopatz and M. King, Functional genomics in the post-genomic era, Upstate
medical University Clinical campus postersession,2003.
184.Aronstam, R.S. and P. Patil, Influence of S-nitrosylation of membrane proteins on muscarinic receptors in
brainstem and CHO cells. J. Neurochem. 104S, 30-31, 2008.
185.Huang, C.-C., R.S. Aronstam, D.-R. Chen and Y.W. Huang, Intracellular calcium modulation and gene
expression alteration in human lung epithelial cells exposed to ZnO nanoparticles, Gordon Conference
presentation,2008.
186.Wang, H., B.A. Wheelden,A.C. Growcock, A.L. Martin, Y. Huang and R.S. Aronstam, Nitric oxide and
muscarinic receptor –mediated signaling: Influence on calcium oscillations, American Society for Cell
Biology, 2008.
187. Huang, C., D. Chen, R.S. Aronstamand Y. Huang, Alterations in oxidative stress,apoptotic pathways,
calcium metabolism and gene expression in human bronchial cells by zinc oxide nanoparticles,American
Society for Cell Biology, 2008.
188. Huang, C.-C., R.S. Aronstam, D.-R. Chen and Y.-w. Huang, Intracellular calcium modulation and gene
expression alteration in human lung epithelial cells exposed to ZnO nanoparticles, Society for Free Radical
Biology and Medicine, 2008.
189. Huang, C.-C., R.S. Aronstam, D.-R. Chen, Y.-W. Huang, Increased intracellular calcium concentrations in
human bronchialepithelial cells exposed to ultrafine zinc oxide particles, Society for Toxicology, 2009.
190. Wang, H.-J., A. Martin. Y.-W. Huang and R.S. Aronstam, Muscarinic M3 receptor mediated intracellular
calcium changes are pH sensitive and dependent,Society for Toxicology, 2009.
191.Huang, Y.-W., C.-C. Huang, Y. Xu and R.S. Aronstam, Metal Oxides Influence Cellular Homeostasis via
Multiple Interconnected Signaling Pathways, Society for Toxicology, 2010.
192. R.S. Aronstam, H.-J. Wang, A.C. Growcock, J. O’Hara, T.-H. Tang, A. Martin and Y.-W. Huang,
Nanoparticle Disruption of Muscarinic Receptor Mediated Signal Transduction,American Society for
Neurochemistry, 2010.

12. 193. H.-J. Wang,T.-H. Tang, A.C. Growcock, J. O’Hara, , A. Martin, Y.-W. Huang and R.S. Aronstam, ZnO
Nanoparticles Alter Muscarinic Receptor Ligand Binding and Activation of SOCE, Society for Toxicology,
2010.
194. Erickson, J.D., C.H. Wu, H.-J. Wang, R.A. Reichard, E.K. Shannon,A.G. Martin, A. Martin, Y.-W. Huang
and R.S. Aronstam, Comparative Effects of Metal Oxide Nanoparticles on Muscarinic Receptor Mediated
Calcium Signaling. American Society for Neurochemistry, 2011.
195. Martin, A.G, C.T. Chang, H.-J. Wang, J.D. Erickson, R.A. Reichard, E.K. Shannon,A. Martin, Y.-W. Huang
and R.S. Aronstam, Halothane Suppresses Calcium Signals Generated in Response to Activation of M3
Receptors Expressed in CHO Cells, American Society for Neurochemistry, 2011.
196.Aronstam, R.S., T.H. Tang, C.T. Chang, H.-J. Wang,J.D. Erickson, A.G. Martin. R.A Reichard, E.K.
Shannon,A Martin and Y.-W. Huang, Disruption of Muscarinic Receptor Signal Transduction by Oxidative
Stress, American Society for Neurochemistry, 2011.
197. J.D. Erickson, H.-J. Wang,Y.-W. Huang, Disruption of Muscarinic Receptor Mediated Signal Transduction
by Oxidative Stress,Society of Toxicology, 2011.
198.Huang, Y.-W., C.C. Chusuei, S. Mallavarapu, J.G. Winiarz, J.-S. Moon and R.S. Aronstam, Searching for
Common Denominators that Explain Cytotoxicity Induced by Metal and Non-metal Nanomaterials, Annual
Meeting EuroTox, Paris, 2011.
199.Martin, A.L., K.Z. Williams, H.L. Chambers, R.A. Reichard, E.K.. Shannon, H.-J. Wang, A.G. Martin and
R.S. Aronstam, Constitutive Activity of Orphan G Protein Coupled Receptors, Annual meeting, American
Society for Cell Biology, Denver, CO, 2011.
200. Martin, A.G., H.-J. Wang,R.A. Reichard, P.-K. Chao, E.K. Shannon,A.L. Martin, Y.-W. Huang, M.-H.
Chang, R.S. Aronstam, Honokiol blocks store operated calcium entry in CHO cells expressing the M3
muscarinic receptor, Annual meeting, American Society for Cell Biology, Denver, CO, 2011.
201.Huang, Y.-W., C.C. Chusuei, S. Mallavarapu and R.S. Aronstam, Mechanisms of Action of Cytotoxicity of
Transition Metal Oxide Nanoparticles in Human Lung Cells, Experimental Biology, 2012.
202. Huang, Y.-W., A. G. Martin, H-J. Wang, P-K. Chao, A. L. Martin1, E. K. Shannon,R. A. Reichard, M-H.
Chang, and R.S. Aronstam Biphenols block calcium entry in response to activation of the M3 muscarinic
receptor, Experimental Biology, 2012.
203.Aronstam, R.A., K.Z. Williams, H.L. Chambers, R.A. Reichard, E.K. Shannon, H.-J. Wang,A.G. Martin, and
A.L. Martin, Orphan G protein coupled receptors: signaling pathways,Annual Meeting, American Society for
Neurochemistry, Baltimore, MD, 2012.
204.Shannon,E.K., A.L. Martin, V.A. Kaighin, A.G.. Martin and R.S. Aronstam, Transcriptional regulation
mediated by muscarinic acetylcholine receptors with native and constitutively active phenotypes,Annual
Meeting, American Society for Neurochemistry, Baltimore, MD, 2012.
205.Yue-Wern Huang, Y.-W., C. Chusuei, C.-H. Wu, S. Mallavarapu, J.G. Winiarz and R.S. Aronstam,
Cytotoxicity of Fourth Period Transition Metal Oxide Nanoparticles Depends on Certain Physicochemical
Properties. TechConnect World Conference Washington,DC. May 12-16, 2013.
206. Yue-Wern Huang, Y.-W., C. Chusuei, C.-H. Wu, S. Mallavarapu, J.G. Winiarz and R.S. Aronstam, Cell
viability and apoptosis induced by transition metal oxide nanoparticles depend on surface charge, available
surface binding site, and ion dissolution, , March 10-14. 52nd Annual Meeting of the Society of Toxicology,
San Antonio, TX, 2013.

13. 207. Martin, A.L., H.L. Chambers, K.Z. Williams and R. AS Aronstam, Constitutive activity of orphan G protein
coupled receptors, Constitutive Activity of Orphan G Protein Coupled Receptors, 4th GPCR Colloquium,
American Society for Pharmacology & Experimental Therapeutics, Boston,MA, April, 2013.
208. Frye, H.E., H.-J. Wang,Y.-W. Haung, A.L. Martin and R.S. Aronstam, M2 muscarinic receptor signaling
through phos-pholipase C mediated by a modified Gαq protein, Annual meeting, American So Cell Biology,
New Orleans, 2013.
209. Huang, Y-W., F.Y.S. Hou, C.-M. Hsu, C.-J. Hsiao and R.S. Aronstam, Mechanisms of toxicity and types of
cell death induced by nanoscale particles, Annualmeeting, American Society for Cell Biology, New Orleans,
LA, 2013.
210. Shannon, E.K., A.L. Martin, H.-J. Wang and R.S. Aronstam, M2 muscarinic receptor control of gene
expression signaling mediated by Gαs, Annual meeting, American Society for Cell Biology, New Orleans,
LA, 2013.
211.Wang, H.-J., S.B. Tobwala, D. Lindgren, R.S. Aronstam, H. Karacal and N. Ercal, N-acetylcysteine amide
(NACA) prevents retinal degeneration induced by sodium iodate in C57BL/6 mice, Free Radical Biology and
Medicine 65 (Suppl. 2), 2013
212. Tolliver, L.M., F.Y.S Hou, H.-J. Lee, R.S. Aronstam and Y.-W. Huang, Distinct patterns of apoptosis and
necrosis in A549 cells by fourth-period transition metal oxide nanoparticles, Society for Toxicology, 2015
Annual Meeting.