Synexus is a clinical research organization that operates dedicated research centers and affiliated sites around the world. It specializes in patient identification, recruitment, and retention for clinical trials. Synexus aims to reduce costs and improve trial timelines through its dedicated research center model and focus on patient engagement and quality management systems. Its global network, experienced staff, and track record demonstrate effective performance across many therapeutic areas.

1. The Synexus Model

2.  What is Synexus?
 Why Synexus Exists
 Synexus Business Models
• Dedicated Research Centre Model
• Affiliated Site Model
 Where Synexus is located
 Patient Engagement – Our Approach
 Our Clinical Experience
 Synexus Quality Management System
 Why does Synexus Succeed?
 Useful Information
Contents

3. Synexus is a unique company that excels in the
identification, recruitment and retention of
patients in our own clinical sites, on behalf of
leading pharmaceutical companies and contract
research organisations.
Together for the future of health
What is Synexus?

4. Old Model – Why Synexus Exists
80,000
sites involved in clinical
research
$50,000
spent opening each site
11%
of sites recruit
0
patients
60%
of sites recruit
1
or less patients
86%
of clinical trials do not finish
on time

5. Locations:
Synexus operates a dedicated research centre model in UK, Bulgaria,
Germany, Hungary, Poland, Romania and South Africa.
Benefits:
The model allows Synexus to recruit large volumes of high quality
patients at a low number of sites.
Results in higher average numbers of patients per Synexus site
compared to the industry average.
By reducing the total number of sites within a study the model allows
Synexus to offer a cost-effective solution to Sponsors and a competitive
advantage to Clinical Research Organisations.
Dedicated Research Centre Model

6. Locations:
In addition to the DRC model, Synexus operates an affiliated site model
in South Africa, Bulgaria, Ukraine and India to offer a wider reach to
patients across these countries. Synexus has an operational
infrastructure within these countries and established relationships with
external sites and Principal Investigators.
Benefits:
The model supports higher access to patients within these sites via the
Synexus global recruitment strategy.
Affiliated sites work within the Synexus Quality Management System
(SQMS) to provide the high quality service and data our customers
expect from any Synexus site.
Affiliated Site Model

7.  Superb, modern facilities that make
patients feel at-ease
 State-of-the-art medical equipment
 Purpose designed offices for visiting
monitoring staff
 Significant investment to achieve the
ultimate efficiency gains
 Central to our innovative methodology
Dedicated Research Centres

8.  130 highly experienced principal
investigators
 174 dedicated nurses caring for our
patients
 All staff are fully trained and
committed to good clinical practice
(GCP)
 Every input double-checked by data
coordinators
 Highest possible standard of care
Equally Dedicated Staff

9.  Our attention is focused entirely on
conducting clinical trials
 Centralised project management and
operating procedures ensure consistent
quality worldwide
 Flexibility to meet the specific needs of a
study
 Continuous cycle of training, analysis, review
and improvement
 One point of contact and one contract for the
entire trial
 A total solution with every step streamlined
The Power of Focus

10. Global Network of
25 Dedicated Research
Centres
&
46 Affiliated Sites
UK (8)
Poland (6+1)
Germany (4+2)
South Africa (4+6)
Hungary (1+4)
Romania (1)
Bulgaria (1+2)
Ukraine (+6)
India (+25)
Global Reach

11. We apply the highest standard of care through their journey with
Synexus
Comfortable waiting rooms
with drinks, snacks & TV
Modern, fully equipped
consulting rooms
Attention on retention.
Patient transport provided
to and from our centres
Close liaison with GP
Detailed patient feedback helps us ensure quality of service
Our Patients are our Number 1 Priority

12. Feasibility &
Proposal
Validate
Plan
Track &
Forecast
Diagnose &
Optimise
Analysis &
Database
Past
Experience
Our Recruitment Planning is Continuous
It starts with feasibility and continues until the last patient is
recruited and retained

13. Background
information and
characteristics
analysed
Professional
execution,
monitoring
and fine tuning
Target audience
defined
Recruitment
methods
optimised for local
situation
Building a Recruitment Campaign
Each new campaign is built on the foundation
of all our previous findings and local best practices

14. We Access and Engage our Patients
Various approaches are used to target approximately
1 million patients within a 30 mile radius of each site
Advertising
• Write to patients from
commercial databases
• Integrated approach (print,
online, radio & TV)
Collaboration for Referrals
• Strong links with professionals
& patient groups to encourage
participation
• Specialist referrals from
cooperating doctors pharmacy
Patient Database
• 630,000+ patients expressed
interest in trials
• Across key TAs and
countries
Community Awareness
• Posters & Leaflets in GP
practices, hospitals, etc.
• Outdoor advertising on
billboards, buses, taxis
• Social media education
GP Relationships
• Engage participating
local GPs to write to
potential patients with
ethically approved letter
Community Liaison
• Interaction with patient
groups and health fairs
• Recruitment team visit
local; centres / clinics

15. Engaging Patients From The Start
The patient journey
Patients respond to local
recruitment activities and are
tele-screened to assess
specific requirements.
Suitable patients are booked
into the clinic
A non-study visit in which the patient’s medical
condition is characterised
A pre-study visit in which the study and procedures
such as consent are explained
GP SDV initiated to confirm medical history
GP
SDV
Qualified Patient

16. Our Therapy Areas

17. Our Clinical Experience
Lipids & Cholesterol Asthma Type I Diabetes
Cardiac Events COPD Type II Diabetes
Hypertension Smoking Cessation Diabetic Foot Ulcer
Heart Failure Osteoporosis Diabetic Neuropathy
Angina Osteoarthritis DPNP
Atrial Fibrillation Ankylosing Spondylitis Alzheimer's Disease
C-Reactive Protein Psoriatic Arthritis Parkinson's Disease
Atopic Dermatitis Rheumatoid Arthritis Restless Leg Syndrome
Acne Human Papilloma Virus Neuralgia
Psoriasis Herpes Zoster Insomnia
Rosacea Influenza Alcohol Dependence
Obesity Travelers Diarrhoea Anxiety
Gout Smallpox Endometriosis
Hyperkalaemia Rotavirus Contraception
Overactive Bladder Neuropathic Pain Menopausal Symptoms
Benign Prostatic Hyperplasia Lower Back Pain Female Sexual Dysfunction
Benign Prostatic Obstruction Knee Pain & Hip Pain HSDD
HIV Prostate Cancer Prevention IBD
Common Cold Tinnitus IBS
Athletes Foot Glaucoma Constipation

18. Subjects Months Sites
Synexus
per Site
Others
per Site
CV Outcomes 2,740 12 11 249 11
Asthma 1,007 20 24 42 14
Osteoporosis 2,461 10 12 205 30
Diabetes 1,023 11 10 102 10
Osteoporosis 1,763 20 20 88 38
Obesity 710 8 9 79 8
Cancer Prevention 1,500 10 10 150 8
CV Outcomes 1,307 24 24 54 21
Lipids 740 9 24 31 4
Osteoarthritis 300 1.6 7 27 7
Flu Vaccine 1,034 1 4 259 86
Hypertension 1,402 7 7 200 25
Proven Performance
Across a Range of Studies

19. The aim of the Synexus Quality Management System (SQMS) is to
achieve excellence in data quality for all our customers. We want to:
 Protect patients (care, confidentiality)
 Meet and exceed customer expectations
 Achieve efficiencies through standardisation across the organisation
This is achieved using a global document system comprising of:
 Company Policies
 Corporate Operating Procedures
 Standard Operating Procedures
SQMS ensures consistency of activities across all Synexus sites which, in
turn, ensures that the highest standard of clinical research is achieved.
Synexus Quality Management System

20.  Conduct all trial activities at our own sites with dedicated
Synexus medics, nurses and support staff
 Proactively recruit patients into clinical trials
 Manage patients throughout the total study lifetime
 Significant cost and time reductions across studies
and entire development programmes
 Underpinned by the Synexus Quality Management System
Why Does Synexus Succeed?

21. Visit our websites
http://www.synexus.com
https://www.synexusclinic.co.uk
View our videos
http://threemotion.vzaar.me/2034161
https://www.youtube.com/watch?v=JjOF_rsR6Dc
Useful Information