A 32-year-old male patient with Werner syndrome, a rare premature aging disorder, was presented for debridement of a non-healing ulcer on his lower limb. Werner syndrome causes accelerated aging symptoms beginning in early adulthood, including cataracts, diabetes, osteoporosis and atherosclerosis. The anesthetic challenges for these patients include difficult airway anatomy due to facial changes, cardiovascular risks, and risks of complications due to accelerated effects of aging. The patient was successfully managed with regional anesthesia and monitored post-operatively due to these increased risks.