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Princeton Scientific Instruments, Inc.




      Princeton Scientific Instruments, Inc.     www.prinsci.com
 7 Deer Park Dr, Monmouth Junction, N.J. 08852   Ph: 732-274-0774
PSI History
Princeton Scientific Instruments is a small, dynamic company engaged in mechanical,
electrical, electronic, software engineering services and research. We have a core group
of employees responding quickly to changing customer demands and a bullpen of
scientists and engineering consultants available to us. PSI has been in business more
than 30 years, originally focused on developing CCD cameras for scientific use. Over the
years we have branched out into areas involving electro-optical systems. Customers
include commercial, government and academia.


Customers have included :
•   Air Force                                   •    Navy
•   Army                                        •    Princeton Plasma Physics Laboratory
•   BANC3                                       •    Princeton Power Systems
•   DARPA                                       •    Princeton University
•   Department of Energy                        •    Sarnoff/SRI
•   General Dynamics                            •    Sci-in Tech
•   Johnson and Johnson                         •    Sensors Unlimited
•   National Institute of Health                •    University of Arizona Lunar and Planetary Laboratory
•   NASA




             Princeton Scientific Instruments, Inc.                                www.prinsci.com    2
        7 Deer Park Dr, Monmouth Junction, N.J. 08852                              Ph: 732-274-0774
PSI Capabilities



 Electronic Circuit Design                                    Assembly
     •   Spice Simulation                                        •   In house or subcontract
     •   Orcad Schematic Capture                                 •   Electronic
     •   PCB (Printed Circuit Board) Layout                      •   Electrical
     •   Analog - amplifiers, filters                            •   Mechanical
     •   Digital – FPGA, Microcontrollers                        •   Optical

 Software                                                   Selection, Coordination and Supervision of
     •   LabVIEW™ for Data Acquisition & Control                 •   Machine Shop, Full CNC machining capabilities
     •   Microcontroller coding                                  •   Plating, Anodizing, Hard Coat and Powder Coat
                                                                 •   Screen printing and Laser Marking
 Mechanical Design and Drafting
     •   CAD ( Computer Aided Design )                            Vacuum System experience
     •   3D Modeling                                             • CCD dewars
     •   2D Mechanical Drawings
     •   Artwork for screen printing and laser marking
                                                            Temperature chamber
                                                                 •   Temperature range -30 to 100 C
 Optical interface & integration
     •   Filter, Lens, beam splitter selection
     •   Photo detectors, LEDs, Lasers




                 Princeton Scientific Instruments, Inc.                                    www.prinsci.com           3
            7 Deer Park Dr, Monmouth Junction, N.J. 08852                                  Ph: 732-274-0774
Projects for a recent Customer


We were tasked with packaging and integration of laboratory instruments and/or designing
new instruments by a customer in the skin care product industry. The skin measurement
instruments we have been involved with over the past 2+ years are:

    •   Diffuse Reflectance Spectrometer (DRS) - Visible light reflectance/absorption
    •   Compact Diffuse Reflectance Spectrometer (CDRS)
    •   Fast Diffuse Reflectance Spectrometer (FDRS)
    •   Spectrofluorometer (SFM) - Fluorescence by exciting the skin in one wavelength
        and measuring the resulting fluorescence in a different wavelength
    •   Skin Displacement Instrument (SDI) - Skin softness by blowing air on the skin and
        measuring the displacement with a laser measuring system
    •   Reviscometer (RVM) - Speed of sound through skin
    •   Dielectric Properties of Skin (DPSI) - Skin resistance
    •   Macro Skin Fluorescence Imaging Probe (MSFIP) – Fluorescence microscope
    •   Multichannel Clinical Imaging System (MCCIS) - Facial DRS

PSI designed, assembled, modified and tested the systems in house.




               Princeton Scientific Instruments, Inc.                  www.prinsci.com      4
          7 Deer Park Dr, Monmouth Junction, N.J. 08852                Ph: 732-274-0774
Diffuse Reflectance Spectrometer (DRS)

Instrument Description:              Used to measure reflectance, absorbance and transmission of Visible light
on the skin.                         Thermo Electric Cooled (TEC) CCD spectrometer, quartz light source.
Custom                               Bifurcated Fiber Optic Probe Instruments delivered with laptop and
installed software. Project Disciplines:         Packaging, Software, Wiring, Mechanical assembly




         3D Cad Model
                                                                  Electro-Mechanical Packaging




                                                                                                            5
          2D Machining drawing                                              Final Product
Diffuse Reflectance Spectrometer (DRS)




           Wiring Diagram




Software Main Screen with
Spectrometer output looking
at fluorescent room light




                                                     6
CDRS (Compact Diffuse Reflectance Spectrometer) Optical Funnel version
Instrument Description:           Replace the Quartz Halogen Lamp with 4 LED’s and the spectrometer with
Silicon                detector used in the DRS instrument
Project Disciplines:   Packaging, Mechanical Design, Electrical design, Software, Wiring, Mechanical
                       assembly




                                    Simplified Block Diagram



                                                                             Optical Funnel cut-away view

                                                                             Optical funnel




                                                                             SMA optical connectors


                                                                             Silicon Detector

                                                                                                      7
                                 3D Cad Model                     Printed Circuit Board
CDRS (Compact Diffuse Reflectance Spectrometer) Optical Funnel version
  Software: Uses the public domain DRS Algorithm to calculate Oxy Hb, Deoxy Hb, Melanin
  and Scattering using the 4 LEDs. Software operates by turning each of the LED’s on in
  sequence then recording the reflected spectra with an off the shelf DAQ module. Data is
  recorded to a text file.




Screen shot of the CDRS software, with strip          Led Single values popup window
chart recording




                                                                                            8
FDRS (Fast Diffuse Reflectance Spectrometer)

This instrument is comprised of a Princeton Instruments spectrometer and can acquire spectra at
~100 frames per second. In addition to performing the same calculations as a DRS, the higher
speed acquisition can also detect lymphatic oscillations occurring at ~10Hz. This project
consisted mainly of customizing software developed for the Spectrofluorometer.




      FDRS Instrument Picture



                                                      FDRS screen shot of software

                                                                                             9
SFM (Spectrofluorometer)
This system is used to measure fluorescence of the skin, and is comprised of a
monochromator, spectrometer, 2 filter wheels and a Xenon Light source. The project involved
packaging and some software modifications in LabVIEW.




                                                                           Screen shot of
                                                                           the software
                                                                           looking at a
                                                                           fluorescent room
                     Front and rear picture of the                         light
                     Spectrofluorometer system




                                                                                              10
     Spectrofluorometer optical path
RVM (Reviscometer)
3D Frame
                                               This project is a modification to an existing instrument
                                               made by Courage + Khazaka electronic GmbH. This
                                               probe uses 2 Piezo transducers, one as a transmitter and
                                               the other as a receiver, in order to measure the speed of
                                               sound through the skin. The original instrument required
                                               the user to manually move the probe. PSI automated the
                                               system by putting the probe in a housing with motors to
                                               provide the required movements.


                        Frame and components




                                                                                Assembled Probe
                                                                                adapter housing
                                                                                Machined from a
                                                                                STEP file
                                                                                                   11
           2D Machining drawing
RVM (Reviscometer)
This project is a modification to an existing instrument made by Courage + Khazaka electronic GmbH. This
probe uses 2 Piezo transducers, one as a transmitter and the other as a receiver, in order to measure the speed
of sound through the skin. The original instrument required the user to manually move the probe. PSI automated
the system by putting the probe in a housing with motors to provide the required movements.




                                                                                  Screen Shot of a typical
                                                                                  Gaussian measurement




            System Block Diagram
                                                                                                             12
DPSI (Dielectric Properties of Skin Instrument)
                                               A lab instrument for
                                               development of customized
                                               sequence steps for VI
                                               characterization of the skin.
                                               Sequences can produce
                                               ramp up, ramp down, or DC
                                               voltages.

                                                The left plot is an Up / Down
                                                ramp demonstrating
                                                characteristic hysteresis of
                                                the skin. The right plot is a
Hysteresis plot                                 DC Step test 1V – 0V using
                                                a test probe with a 500KΩ
                                                resistor and a .1uF capacitor
                                                in series.

                                                This device uses a lab power
                                                supply, capable of delivering
                                                200V at >50mA, therefore a
                                                protective interface was
                                                designed to trip if current or
                                                voltage exceed safe levels.


                                                                          13
DC Step test with RC Test probe
MSFIP (Macro Skin Fluorescence Imaging Probe)

This project uses 3 Visible Lasers and a quartz Halogen visible light source along with a filter
Wheel, shutter, and video camera. Laser beams are confined in fiber optic cables and are
routed through an optical switch. An interface board was designed to control the functions of
the devices and to provide a Watch Dog Timer for safe laser operation.




Screen Shot imaging a Fluorescence Reference under a transparent grid through a 620nm
14nm FWHM filter                                                                              14
MSFIP (Macro Skin Fluorescence Imaging Probe) block Diagram




                                                              15
MCCIS (Multi Channel Clinical Imaging System) A packaging project




          3D Cad views




                          Assembled product




                                                                    16
Dynamic Muzzle Reference System
3D CAD Modeling
                                                       A system for measuring the bending of a tank barrel




                                           Receiver
                                           Unit
                                           Assembly
                  Receiver Unit
                  Housing




           Emitter Optical Tube




           Prism Housing                              Machined from 2D Drawings                       17
Dynamic Muzzle Reference System



Receiver Electronics Unit




                                            Receiver Unit

                             Emitter Unit
               Prism




                                                              18
Laser Hazard Detector System




Assembled system                                  Video Processor PC board


     •   Visible to Near IR Laser Detection
     •   Intensity, Wavelength, origin angle, Pulsed or CW




                                                                             19
FLEET (Femtosecond Laser Electronic Excitation Tagging)
This project involves a collaboration with Princeton University (http://www.princeton.edu/mae/ )
 Femtosecond Laser Electronic Excitation Tagging (FLEET). This method of tagging the
exhaust stream of a jet engine requires no seeding of the gas flow. The laser induced
fluorescence is imaged downstream, and the distortion of the laser line can be used to find the
velocity profile of the flow. Our fast camera technology is used to provide multiple downstream
images with a single data acquisition. Our website has some videos of other fast camera
applications. Measurement of turbulent structure in the exhaust of an F-35 for the study of
noise generation and control.




From Professor R. Miles Princeton University                      PSI Fast Camera             20
Astronomy Telescope Shutter Controller

Sci-in Tech (www.sciin.com) makes large
aperture photometric shutters for use in
astronomy. These shutters are in use at
various telescopes around the world. An
embedded micro-controller provides the
triggering and timing control to the motors
that drive the shutter blades. See the
website for more information.

       Electronic and Mechanical packaging

        Black Anodizing and Laser Marking         Printed Circuit Board Design and Assembly




                                                                                              21
Princeton Scientific Instruments, Inc.
          7 Deer Park Drive
    Monmouth Junction, NJ 08852
           Ph 732-274-0774
          Fax: 732-274-0775
   Email: glemunyan@prinsci.com




      Princeton Scientific Instruments, Inc.     www.prinsci.com    22
 7 Deer Park Dr, Monmouth Junction, N.J. 08852   Ph: 732-274-0774

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Princeton Scientific Instruments

  • 1. Princeton Scientific Instruments, Inc. Princeton Scientific Instruments, Inc. www.prinsci.com 7 Deer Park Dr, Monmouth Junction, N.J. 08852 Ph: 732-274-0774
  • 2. PSI History Princeton Scientific Instruments is a small, dynamic company engaged in mechanical, electrical, electronic, software engineering services and research. We have a core group of employees responding quickly to changing customer demands and a bullpen of scientists and engineering consultants available to us. PSI has been in business more than 30 years, originally focused on developing CCD cameras for scientific use. Over the years we have branched out into areas involving electro-optical systems. Customers include commercial, government and academia. Customers have included : • Air Force • Navy • Army • Princeton Plasma Physics Laboratory • BANC3 • Princeton Power Systems • DARPA • Princeton University • Department of Energy • Sarnoff/SRI • General Dynamics • Sci-in Tech • Johnson and Johnson • Sensors Unlimited • National Institute of Health • University of Arizona Lunar and Planetary Laboratory • NASA Princeton Scientific Instruments, Inc. www.prinsci.com 2 7 Deer Park Dr, Monmouth Junction, N.J. 08852 Ph: 732-274-0774
  • 3. PSI Capabilities  Electronic Circuit Design  Assembly • Spice Simulation • In house or subcontract • Orcad Schematic Capture • Electronic • PCB (Printed Circuit Board) Layout • Electrical • Analog - amplifiers, filters • Mechanical • Digital – FPGA, Microcontrollers • Optical  Software  Selection, Coordination and Supervision of • LabVIEW™ for Data Acquisition & Control • Machine Shop, Full CNC machining capabilities • Microcontroller coding • Plating, Anodizing, Hard Coat and Powder Coat • Screen printing and Laser Marking  Mechanical Design and Drafting • CAD ( Computer Aided Design )  Vacuum System experience • 3D Modeling • CCD dewars • 2D Mechanical Drawings • Artwork for screen printing and laser marking Temperature chamber • Temperature range -30 to 100 C  Optical interface & integration • Filter, Lens, beam splitter selection • Photo detectors, LEDs, Lasers Princeton Scientific Instruments, Inc. www.prinsci.com 3 7 Deer Park Dr, Monmouth Junction, N.J. 08852 Ph: 732-274-0774
  • 4. Projects for a recent Customer We were tasked with packaging and integration of laboratory instruments and/or designing new instruments by a customer in the skin care product industry. The skin measurement instruments we have been involved with over the past 2+ years are: • Diffuse Reflectance Spectrometer (DRS) - Visible light reflectance/absorption • Compact Diffuse Reflectance Spectrometer (CDRS) • Fast Diffuse Reflectance Spectrometer (FDRS) • Spectrofluorometer (SFM) - Fluorescence by exciting the skin in one wavelength and measuring the resulting fluorescence in a different wavelength • Skin Displacement Instrument (SDI) - Skin softness by blowing air on the skin and measuring the displacement with a laser measuring system • Reviscometer (RVM) - Speed of sound through skin • Dielectric Properties of Skin (DPSI) - Skin resistance • Macro Skin Fluorescence Imaging Probe (MSFIP) – Fluorescence microscope • Multichannel Clinical Imaging System (MCCIS) - Facial DRS PSI designed, assembled, modified and tested the systems in house. Princeton Scientific Instruments, Inc. www.prinsci.com 4 7 Deer Park Dr, Monmouth Junction, N.J. 08852 Ph: 732-274-0774
  • 5. Diffuse Reflectance Spectrometer (DRS) Instrument Description: Used to measure reflectance, absorbance and transmission of Visible light on the skin. Thermo Electric Cooled (TEC) CCD spectrometer, quartz light source. Custom Bifurcated Fiber Optic Probe Instruments delivered with laptop and installed software. Project Disciplines: Packaging, Software, Wiring, Mechanical assembly 3D Cad Model Electro-Mechanical Packaging 5 2D Machining drawing Final Product
  • 6. Diffuse Reflectance Spectrometer (DRS) Wiring Diagram Software Main Screen with Spectrometer output looking at fluorescent room light 6
  • 7. CDRS (Compact Diffuse Reflectance Spectrometer) Optical Funnel version Instrument Description: Replace the Quartz Halogen Lamp with 4 LED’s and the spectrometer with Silicon detector used in the DRS instrument Project Disciplines: Packaging, Mechanical Design, Electrical design, Software, Wiring, Mechanical assembly Simplified Block Diagram Optical Funnel cut-away view Optical funnel SMA optical connectors Silicon Detector 7 3D Cad Model Printed Circuit Board
  • 8. CDRS (Compact Diffuse Reflectance Spectrometer) Optical Funnel version Software: Uses the public domain DRS Algorithm to calculate Oxy Hb, Deoxy Hb, Melanin and Scattering using the 4 LEDs. Software operates by turning each of the LED’s on in sequence then recording the reflected spectra with an off the shelf DAQ module. Data is recorded to a text file. Screen shot of the CDRS software, with strip Led Single values popup window chart recording 8
  • 9. FDRS (Fast Diffuse Reflectance Spectrometer) This instrument is comprised of a Princeton Instruments spectrometer and can acquire spectra at ~100 frames per second. In addition to performing the same calculations as a DRS, the higher speed acquisition can also detect lymphatic oscillations occurring at ~10Hz. This project consisted mainly of customizing software developed for the Spectrofluorometer. FDRS Instrument Picture FDRS screen shot of software 9
  • 10. SFM (Spectrofluorometer) This system is used to measure fluorescence of the skin, and is comprised of a monochromator, spectrometer, 2 filter wheels and a Xenon Light source. The project involved packaging and some software modifications in LabVIEW. Screen shot of the software looking at a fluorescent room Front and rear picture of the light Spectrofluorometer system 10 Spectrofluorometer optical path
  • 11. RVM (Reviscometer) 3D Frame This project is a modification to an existing instrument made by Courage + Khazaka electronic GmbH. This probe uses 2 Piezo transducers, one as a transmitter and the other as a receiver, in order to measure the speed of sound through the skin. The original instrument required the user to manually move the probe. PSI automated the system by putting the probe in a housing with motors to provide the required movements. Frame and components Assembled Probe adapter housing Machined from a STEP file 11 2D Machining drawing
  • 12. RVM (Reviscometer) This project is a modification to an existing instrument made by Courage + Khazaka electronic GmbH. This probe uses 2 Piezo transducers, one as a transmitter and the other as a receiver, in order to measure the speed of sound through the skin. The original instrument required the user to manually move the probe. PSI automated the system by putting the probe in a housing with motors to provide the required movements. Screen Shot of a typical Gaussian measurement System Block Diagram 12
  • 13. DPSI (Dielectric Properties of Skin Instrument) A lab instrument for development of customized sequence steps for VI characterization of the skin. Sequences can produce ramp up, ramp down, or DC voltages. The left plot is an Up / Down ramp demonstrating characteristic hysteresis of the skin. The right plot is a Hysteresis plot DC Step test 1V – 0V using a test probe with a 500KΩ resistor and a .1uF capacitor in series. This device uses a lab power supply, capable of delivering 200V at >50mA, therefore a protective interface was designed to trip if current or voltage exceed safe levels. 13 DC Step test with RC Test probe
  • 14. MSFIP (Macro Skin Fluorescence Imaging Probe) This project uses 3 Visible Lasers and a quartz Halogen visible light source along with a filter Wheel, shutter, and video camera. Laser beams are confined in fiber optic cables and are routed through an optical switch. An interface board was designed to control the functions of the devices and to provide a Watch Dog Timer for safe laser operation. Screen Shot imaging a Fluorescence Reference under a transparent grid through a 620nm 14nm FWHM filter 14
  • 15. MSFIP (Macro Skin Fluorescence Imaging Probe) block Diagram 15
  • 16. MCCIS (Multi Channel Clinical Imaging System) A packaging project 3D Cad views Assembled product 16
  • 17. Dynamic Muzzle Reference System 3D CAD Modeling A system for measuring the bending of a tank barrel Receiver Unit Assembly Receiver Unit Housing Emitter Optical Tube Prism Housing Machined from 2D Drawings 17
  • 18. Dynamic Muzzle Reference System Receiver Electronics Unit Receiver Unit Emitter Unit Prism 18
  • 19. Laser Hazard Detector System Assembled system Video Processor PC board • Visible to Near IR Laser Detection • Intensity, Wavelength, origin angle, Pulsed or CW 19
  • 20. FLEET (Femtosecond Laser Electronic Excitation Tagging) This project involves a collaboration with Princeton University (http://www.princeton.edu/mae/ ) Femtosecond Laser Electronic Excitation Tagging (FLEET). This method of tagging the exhaust stream of a jet engine requires no seeding of the gas flow. The laser induced fluorescence is imaged downstream, and the distortion of the laser line can be used to find the velocity profile of the flow. Our fast camera technology is used to provide multiple downstream images with a single data acquisition. Our website has some videos of other fast camera applications. Measurement of turbulent structure in the exhaust of an F-35 for the study of noise generation and control. From Professor R. Miles Princeton University PSI Fast Camera 20
  • 21. Astronomy Telescope Shutter Controller Sci-in Tech (www.sciin.com) makes large aperture photometric shutters for use in astronomy. These shutters are in use at various telescopes around the world. An embedded micro-controller provides the triggering and timing control to the motors that drive the shutter blades. See the website for more information. Electronic and Mechanical packaging Black Anodizing and Laser Marking Printed Circuit Board Design and Assembly 21
  • 22. Princeton Scientific Instruments, Inc. 7 Deer Park Drive Monmouth Junction, NJ 08852 Ph 732-274-0774 Fax: 732-274-0775 Email: glemunyan@prinsci.com Princeton Scientific Instruments, Inc. www.prinsci.com 22 7 Deer Park Dr, Monmouth Junction, N.J. 08852 Ph: 732-274-0774