Micro-needle as drug delivery system

1. Microneedles
PH.D Student : Omar Saeb Salih
Baghdad university
College of pharmacy
Department of Pharmaceutics
2020-2021
omar.abbas@copharm.uobaghdad.edu.iq
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2. Objectives:
• Skin anatomy
• History and literatures
• Why microneedling?
• Advantages
• Types of microneedles
• Methods of preparation
• Evaluation
• Applications
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3. Skin
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4. History
• The concept of microneedles for drug delivery came about in the
1960s, and it was patented by Alza Corporation in 1971. (1)
• This concept was experimentally tested almost 30 years later, with the
extensive development of microfabrication manufacturing
technology.(2)
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5. Year wise (from 2000 to 2019) trend in MN array-based research(3)
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6. Why microneedling?
Simple, inexpensive and self
-administrated
Greater patient satisfaction
Dermatological therapy
Easily disposable
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7. Advantages
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8. Types of microneedles
SOLID COATED DISSOLVING HOLLOW
Different types of microneedle were prepared depend on the purpose of use (4)
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9. Solid microneedles
Solid
microneedles
are of four
types
Silicon Metal
Polymer
Glass
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10. Coated microneedles
• Coating solution contains :-
1-Drugs
2-Exipients (like thickening agent,surfactant,stablizers etc.)
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11. Dissolving microneedles
Drug encapsulated
within biodegradable,
polymeric microneedles,
followed by the insertion
into the skin for drug
release.
Polymers used:
PLA, PGA, PLGA,
PVP, Polycarbonate.
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12. Drug
solution
Polymer
solution
Shaping
technique
Patch system
Drug
Solvent
Drug
solution
Polymer-drug
solution Microneedle
fabrication
Patch
application
①
② ③ ④
Micro molding
Drawing
Any class of
drugs can be
used
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13. MN production with micro molding consisted of (a) pouring
the liquid formulation,(b) vacuum degasification, (c) drying,
and (d) removal of MNs from the mold.(5)
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15. Hollow microneedles
Lumen diameter
30μm and height
250μm.
Carry drug continuously into the body by
diffusion
Large amount of drug are delivered
Remove fluid
from the body for
analysis
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16. Methods of preparation
Coating
Laser cutting
3D printing
Photolithography
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17. Laser cutting
Microneedles are cut from stainless steel sheets using an infrared laser.
The desired microneedle shape and dimensions are first drafted in
AutoCAD software.
Using this design laser energy is used to cut the microneedles.
A cutting speed of 2 mm/s and air purge at a constant pressure of 140
kPa is used.
Microneedles are either prepared as in-plane needles or as out of the plane
microneedles
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18. Photolithography
• This techniques involves deposition of thin films of material on a
substrate.(6)
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RIE: Reactive ion etching

19. 3d Printer
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20. Evaluation
• Rigidness: Must be able to withstand the insertion force
without being fractured.
• Penetration: Must penetrate the drug to required depth in the
tissues.
• Dimensions: Length: 100-900microns; Base widht:50-
300microns,Tip diameter: 1-50microns.(7)
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21. Evaluation
It is carried out to
determine
optimization of
microneedles,
penetration force,
strength of
microneedles,
delivery efficacy etc.
Preclinical evaluation
of microneedles was
performed on animals
like mice order to
determine the
delivery efficacy,
penetration force,
bending force.(8)
In
Vitro
In
vivo
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22. Applications
INSULIN
DELIVERY
VACCINE
DELIVERY
LOCAL
TISSUE
DELIVERY
TRANSDERMAL
DRUG
DELIVERY
Mesotherapy
Drugs like
NSAIDS
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23. • List of microneedle drug delivery systems(6)
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24. Future prospectives
•Microneedles can be used for delivery
of nanoparticles.
•Microneedles can be used for vesicular
drug delivery like ethosomes.
•Delivery of proteins.
•Delivery of anticancer drugs.
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55 paper

26. Thank you for
listening!
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27. Questions
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