This drug could help fight global obesity epidemic

1. This drug could help fight global
obesity epidemic
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2. Contd..
• It Prevents Body From Absorbing Fat Scientists of the
United States have designed a new class of compounds that
may reduce weight gain by preventing the body from
absorbing fat particles.Research has shown that worldwide,
obesity rates have been climbing for years.
• Even currently available antiobesity drugs can have serious
side effects, including increased risk of cardiovascular
disease and depression. Other treatments for overweight
and obesity include diet and exercise, surgery .
• To help address the global obesity epidemic, scientists are
developing a new class of compounds called “micelle
sequestrant polymers,“ or MSPs, that could prevent fat
particles from getting absorbed in the body and thus
potentially reduce weight gain.
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3. Contd..
• Targeting the body's process of absorbing fat, researchers from the
University of Kansas in US designed a class of polymers that capture
fat particles called micelles in the intestines so that they can't be
digested. Instead, they pass through the gut and are excreted.
• “We designed and engineered a new class of orally acting
pharmaceutical agents, or micelle sequestrant polymers (MSPs),
that could respond to the pH change in the gastrointestinal (GI)
tract and potentially sequester lipid micelles; inhibiting lipid
absorption through a pH-triggered flocculation process,“
researchers said.
• In tests, mice who took these MSPs had nine to 10 times the
amount of triglycerides, the main dietary fat, in their feces than the
control animals. Additionally , because the MSPs pass through the
body unabsorbed, the researchers say they could provide a safe
approach for long-term treatment.
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