It is type a disorder which is generally caused new born baby or infants. A drug antibiotic which is responsible for causing gray patches on body that’s by called gray baby syndrome

1. A
Presentation on
Grey Baby syndrome
Presented By Under the supervision of
LOKESH SINGH Dr.MAYANK KULSHRESHTA
B.Pharm 3rd Year Professor
Rajiv Academy for Pharmacy,
Mathura
2022-2023

3. INTRODUCTION-
It is a circulatory collapse that can occur in
premature and new born infants.
It is a rare disorder that is caused due to presense
of high level of Chloramphenicol in babies born
prematurely.

4. Causes of gray baby syndrome-
The primary cause is the accumulation of the antibiotic
chloramphenicol.
Blood serum level of chloramphenicol higher than per
50mg/ml is assosiated with Gray Baby Syndrome.

5. DEFICIENCY IN NEONATES
• The immature liver may not able to met New born
kidney are not efficient enough to excrete.
• Chloramphenicol and it’s metabolic product from the
body abolize the Chloramphenicol

6. SYMPTOMS-
POOR FEEDING
WEAKNESS
VOMITTING
PALE APPEARANCE
ABDOMINAL DISTENTION

7. Mechanism of chloramphenicol

8. Diagnosis of gray baby syndrome
 Diagnosis of the gray baby syndrome can be made from the
ashen–gray appearance of the skin along with the history of
exposure to chloramphenicol in babies
a) Blood tests
b) CT scan
c) ECG(Electrocardiography)

9. Treatment Of Gray Baby Syndrome
• the treatment for gray baby syndrome is intensive support
therapy with the withdrawal of chloramphenicol .
• They may receive appropriate oxygen therapy, ventilation &
early intubation depending upon the requirement
a) Activate charcoal Hemoperfusion.
b) Exchange transfusion.